Method of reducing stromelysin RNA via ribozymes

ABSTRACT

An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an arthritic condition.

This application is a division of Draper et al., U.S. Ser. No.08/390,850, filed Feb. 17, 1995, now U.S. Pat. No. 5,612,215, (herebyincorporated by reference herein in totality, including drawings) whichis a continuation-in-part of Draper et al., U.S. Ser. No. 08/354,920filed Dec. 13, 1994, now abandoned, which is a continuation-in-part ofDraper et al., U.S. Ser. No. 08/152,487 filed Nov. 12, 1993, nowabandoned, which is a continuation-in-part of, Draper et al. entitled"Method and Reagent For Treatment of Arthritic Conditions," U.S. Ser.No. 07/989,848 filed Dec. 7, 1992, now abandoned, the whole of all ofwhich, including drawings, are hereby incorporated by reference herein.

BACKGROUND OF THE INVENTION

This invention relates to methods for inhibition of osteoarthritis, inparticular, inhibition of genetic expression which leads to a reductionor elimination of extracellular matrix digestion by matrixmetalloproteinases.

There are several types of arthritis, with osteoarthritis and rheumatoidarthritis being predominant. Osteoarthritis is a slowly progressivedisease characterized by degeneration of articular cartilage withproliferation and remodeling of subchondral bone. It presents with aclinical picture of pain, deformity, and loss of joint motion.Rheumatoid arthritis is a chronic systemic inflammatory disease.Rheumatoid arthritis may be mild and relapsing or severe andprogressive, leading to joint deformity and incapacitation.

Arthritis is the major contributor to functional impairment among theolder population. It is the major cause of disability and accounts for alarge proportion of the hospitalizations and health care expenditures ofthe elderly. Arthritis is estimated to be the principal cause of totalincapacitation for about one million persons aged 55 and older and isthought to be an important contributing cause for about one millionmore.

Estimating the incidence of osteoarthritis is difficult for severalreasons. First, osteoarthritis is diagnosed objectively on the basis ofreading radiographs, but many people with radiologic evidence of diseasehave no obvious symptoms. Second, the estimates of prevalence are basedupon clinical evaluations because radiographic data is not available forall afflicted joints. In the NHANESI survey of 1989, data were basedupon a thorough musculoskeletal evaluation during which anyabnormalities of the spine, knee, hips, and peripheral joints were notedas well as other specific diagnoses. Based on these observations, 12% ofthe U.S. population between 25 and 74 years of age have osteoarthritis.

It is generally agreed that rheumatoid arthritis has a world-widedistribution and affects all racial and ethnic groups. The exactprevalence in the U.S. is unknown but has been estimated to rangebetween 0.5% and 1.5%. Rheumatoid arthritis occurs at all age levels andgenerally increases in prevalence with advancing age. It is 2-3 timesmore prevalent in women than in men and peak incidence occurs between40-60 years of age. In addition to immunological factors, environmental,occupational and psychosocial factors have been studied for potentialetiologic roles in the disease.

The extracellular matrix of multicellular organisms plays an importantrole in the formation and maintenance of tissues. The meshwork of theextracellular matrix is deposited by resident cells and provides aframework for cell adhesion and migration, as well as a permeabilitybarrier in cell-cell communication. Connective tissue turnover duringnormal growth and development or under pathological conditions isthought to be mediated by a family of neutral metalloproteinases, whichare zinc-containing enzymes that require calcium for full activity. Theregulation of metalloproteinase expression is cell-type specific and mayvary among species.

The best characterized of the matrix metalloproteinases, interstitialcollagenase (MMP-1), is specific for collagen types I, II, and III.MMP-1 cleaves all three chains of the triple helix at a single pointinitiating sequential breakdown of the interstitial collagens.Interstitial collagenase activity has been observed in rheumatoidsynovial cells as well as in the synovial fluid of patients withinflammatory arthritis. Gelatinasea (MMP-2) represent a subgroup of themetalloproteinases consisting of two distinct gene products; a 70 kDagelatinase expressed by most connective tissue cells, and a 92 kDagelatinase expressed by inflammatory phagocytes and tumor cells. Thelarger enzyme is expressed by macrophages, SV-40 transformedfibroblasts, and neutrophils. The smaller enzyme is secreted by H-rastransformed bronchial epithelial cells and tumor cells, as well asnormal human skin fibroblasts. These enzymes degrade gelatin (denaturedcollagen) as well as native collagen type XI. Stromelysin (MMP-3) has awide spectrum of action on molecules composing the extracellular matrix.It digests proteoglycans, fibronectin, laminin, type IV and IX collagensand gelatin, and can remove the N-terminal propeptide region fromprocollagen, thus activating the collagenase. It has been found in humancartilage extracts, rheumatoid synovial cells, and in the synovium andchondrocytes of joints in rats with collagen-induced arthritis.

Both osteoarthritis and rheumatoid arthritis are treated mainly withcompounds that inhibit cytokine or growth-factor induced synthesis ofthe matrix metalloproteinases which are involved in the extracellularmatrix destruction observed in these diseases. Current clinicaltreatments rely upon dexamethasone and retinoid compounds, which arepotent suppressors of a variety of metalloproteinases. The globaleffects of dexamethasone and retinoid treatment upon gene expression intreated cells make the development of alternative therapies desirable,especially for long term treatments. Recently, it was shown thatgamma-interferon suppressed lipopolysaccharide induced collagenase andstromelysin production in cultured macrophages. Also, tissue growthfactor-β (TGF-β) has been shown to block epidermal growth factor (EGF)induction of stromelysin synthesis in vitro. Experimental protocolsinvolving gene therapy approaches include the controlled expression ofthe metalloproteinase inhibitors TIMP-1 and TIMP-2. Of the latter threeapproaches, only γ-interferon treatment is currently feasible in aclinical application.

SUMMARY OF THE INVENTION

Applicant notes that the inhibition of collagenase and stromelysinproduction in the synovial membrane of joints can be accomplished usingribozymes and antisense molecules. Ribozyme treatment can be a partnerto current treatments which primarily target immune cells reacting topre-existing tissue damage. Early ribozyme or antisense treatment whichreduces the collagenase or stromelysin-induced damage can be followed bytreatment with the anti-inflammatories or retinoids, if necessary. Inthis manner, expression of the proteinases can be controlled at bothtranscriptional and translational levels. Ribozyme or antisensetreatment can be given to patients expressing radiological signs ofosteoarthritis prior to the expression of clinical symptoms. Ribozyme orantisense treatment can impact the expression of stromelysin withoutintroducing the non-specific effects upon gene expression whichaccompany treatment with the retinoids and dexamethasone. The ability ofstromelysin to activate procollagenase indicates that a ribozyme orantisense molecule which reduces stromelysin expression can also be usedin the treatment of both osteoarthritis (which is primarily astromelysin-associated pathology) and rheumatoid arthritis (which isprimarily related to enhanced collagenase activity).

While a number of cytokines and growth factors induce metalloproteinaseactivities during wound healing and tissue injury of apre-osteoarthritic condition, these molecules are not preferred targetsfor therapeutic intervention. Primary emphasis is placed upon inhibitingthe molecules which are responsible for the disruption of theextracellular matrix, because most people will be presenting radiologicor clinical symptoms prior to treatment. The most versatile of themetalloproteinases (the molecule which can do the most structural damageto the extracellular matrix, if not regulated) is stromelysin.Additionally, this molecule can activate procollagenase, which in turncauses further damage to the collagen backbone of the extracellularmatrix. Under normal conditions, the conversion of prostromelysin toactive stromelysin is regulated by the presence of inhibitors calledTIMPs (tissue inhibitors of MMP). Because the level of TIMP in synovialcells exceeds the level of prostromelysin and stromelysin activity isgenerally absent from the synovial fluid associated with non-arthritictissues, the toxic effects of inhibiting stromelysin activity innon-target cells should be negligible.

Thus, the invention features use of ribozymes or antisense molecules totreat or prevent arthritis, particularly osteoarthritis, e.g., byinhibiting the synthesis of the prostromelysin molecule in synovialcells, or by inhibition of other matrix metalloproteinases discussedabove. Cleavage of targeted mRNAs (stromelysin mRNAs, includingstromelysin 1, 2, and 3, and collagenase) expressed in macrophages,neutrophils and synovial cells represses the synthesis of the zymogenform of stromelysin, prostromelysin.

Those in the art will recognize the other potential targets discussedabove are also suitable for treatment with ribozymes, which will reducethe risk or occurrence of pathologic degradation of the extracellularmatrix such as the collagenase and gelatinase metalloproteinases, otherproteinases which can activate the proenzyme forms of themetalloproteinases in synovial fluid or cartilaginous cells, cytokinesor growth factors which activate the expression of themetalloproteinases and adhesion molecules which attract macrophage andneutrophils to the areas of tissue injury.

Ribozymes are RNA molecules having an enzymatic activity which is ableto repeatedly cleave other separate RNA molecules in a nucleotide basesequence specific manner. It is said that such enzymatic RNA moleculescan be targeted to virtually any RNA transcript and efficient cleavagehas been achieved in vitro. Kim et al., 84 Proc. Nat. Acad. of Sci. USA8788, 1987; Haseloff and Gerlach, 334 Nature 585, 1988; Cech, 260 JAMA3030, 1988; and Jefferies et al., 17 Nucleic Acid Research 1371, 1989.

Six basic varieties of naturally-occurring enzymatic RNAs are knownpresently. Each can catalyze the hydrolysis of RNA phosphodiester bondsin trans (and thus can cleave other RNA molecules) under physiologicalconditions. Table I summarizes some of the characteristics of theseribozymes. In general, enzymatic nucleic acids act by first binding to atarget RNA. Such binding occurs through the target binding portion of aenzymatic nucleic acid which is held in close proximity to an enzymaticportion of the molecule that acts to cleave the target RNA. Thus, theenzymatic nucleic acid first recognizes and then binds a target RNAthrough complementary base-pairing, and once bound to the correct site,acts enzymatically to cut the target RNA. Strategic cleavage of such atarget RNA will destroy its ability to direct synthesis of an encodedprotein. After an enzymatic nucleic acid has bound and cleaved its RNAtarget, it is released from that RNA to search for another target andcan repeatedly bind and cleave new targets.

By "enzymatic RNA molecule" it is meant an RNA molecule which hascomplementarity in a substrate binding region to a specified mRNAtarget, and also has an enzymatic activity which is active tospecifically cleave that mRNA. That is, the enzymatic RNA molecule isable to intermolecularly cleave mRNA and thereby inactivate a targetmRNA molecule. This complementarity functions to allow sufficienthybridization of the enzymatic RNA molecule to the target RNA to allowthe cleavage to occur. One hundred percent complementarity is preferred,but complementarity as low as 50-75% may also be useful in thisinvention. For in vivo treatment, oomplementarity between 30 and 45bases is preferred; although lower numbers are also useful.

By "complementary" is meant a nucleotide sequence that can form hydrogenbond(s) with other nucleotide sequence by either traditionalWatson-Crick or other non-traditional types (for example Hoogsteen type)of base-paired interactions.

The enzymatic nature of a ribozyme is advantageous over othertechnologies, such as antisense technology (where a nucleic acidmolecule simply binds to a nucleic acid target to block its translation)since the concentration of ribozyme necessary to affect a therapeutictreatment is lower than that of an antisense oligonucleotide. Thisadvantage reflects the ability of the ribozyme to act enzymatically.Thus, a single ribozyme molecule is able to cleave many molecules oftarget RNA. In addition, the ribozyme is a highly specific inhibitor,with the specificity of inhibition depending not only on the basepairing mechanism of binding to the target RNA, but also on themechanism of target RNA cleavage. Single mismatches, orbase-substitutions, near the site of cleavage can completely eliminatecatalytic activity of a ribozyme. Similar mismatches in antisensemolecules do not prevent their action (Woolf, T. M., et al., 1992, Proc.Natl. Acad. Sci. USA, 89, 7305-7309). Thus, the specificity of action ofa ribozyme is greater than that of an antisense oligonucleotide bindingthe same RNA site.

In preferred embodiments of this invention, the enzymatic nucleic acidmolecule is formed in a hammerhead or hairpin motif, but may also beformed in the motif of a hepatitis delta virus, group I intron or RNasePRNA (in association with an RNA guide sequence) or Neurospora VS RNA.Examples of such hammerhead motifs are described by Rossi et al., 1992,Aids Research and Human Retroviruses 8, 183, of hairpin motifs by Hampelet al., EPA 0360257, Hampel and Tritz, 1989 Biochemistry 28, 4929, andHampel et al., 1990 Nucleic Acids Res. 18, 299, and an example of thehepatitis delta virus motif is described by Perrotta and Been, 1992Biochemistry 31, 16; of the RNaseP motif by Guerrier-Takada et al.,198,3 Cell 35, 849, Neurospora VS RNA ribozyme motif is described byCollins (Saville and Collins, 1990 Cell 61, 685-696; Saville andCollins, 1991 Proc. Natl. Acad. Sci. USA 88, 8826-8830; Collins andOlive, 1993 Biochemistry 32, 2795-2799) and of the Group I intron byCech et al., U.S. Pat. No. 4,987,071. These specific motifs are notlimiting in the invention and those skilled in the art will recognizethat all that is important in an enzymatic nucleic acid molecule of thisinvention which is complementary to one or more of the target gene RNAregions, and that it have nucleotide sequences within or surroundingthat substrate binding site which impart an RNA cleaving activity to themolecule.

The invention provides a method for producing a class of enzymaticcleaving agents which exhibit a high degree of specificity for the RNAof a desired target. The enzymatic nucleic acid molecule is preferablytargeted to a highly conserved sequence region of a target stromelysinencoding mRNAs such that specific treatment of a disease or conditioncan be provided with either one or several enzymatic nucleic acids. Suchenzymatic nucleic acid molecules can be delivered exogenously tospecific cells as required. Alternatively, the ribozymes can beexpressed from DNA or RNA vectors that are delivered to specific cells.

Synthesis of nucleic acids greater than 100 nucleotides in length isdifficult using automated methods, and the therapeutic cost of suchmolecules is prohibitive. In this invention, small enzymatic nucleicacid motifs (e.g., of the hammerhead or the hairpin structure) are usedfor exogenous delivery. The simple structure of these moleculesincreases the ability of the enzymatic nucleic acid to invade targetedregions of the mRNA structure. However, these catalytic RNA moleculescan also be expressed within cells from eukaryotic promoters (e.g.,Scanlon et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 10591-5;Kashani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Dropulic etal., 1992 J. Virol, 66, 1432-41; Weerasinghe et al., 1991 J. Virol, 65,5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chenet al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science247, 1222-1225). Those skilled in the art realize that any ribozyme canbe expressed in eukaryotic cells from the appropriate DNA vector. Theactivity of such ribozymes can be augmented by their release from theprimary transcript by a second ribozyme (Draper et al., PCT WO 93/23569,and Sullivan et al., PCT WO 94/02595, both hereby incorporated in theirtotality by reference herein; Ohkawa et al., 1992 Nucleic Acids Symp.Ser., 27, 15-6; Taira et al., 1991, Nucleic Acids Res., 19, 5125-30;Ventura et al., 1993 Nucleic Acids Res., 21,3249-55; Chowrira et al.,1994 J. Biol. Chem. 269, 25856).

Ribozyme therapy, due to its exquisite specificity, is particularlywell-suited to target mRNA encoding factors that contribute to diseasepathology. Thus, ribozymes that cleave stromelysin mRNAs may representnovel therapeutics for the treatment of asthma.

Thus, in a first aspect, the invention features ribozymes that inhibitstromelysin production. These chemically or enzymatically synthesizedRNA molecules contain substrate binding domains that bind to accessibleregions of their target mRNAs. The RNA molecules also contain domainsthat catalyze the cleavage of RNA. The RNA molecules are preferablyribozymes of the hammerhead or hairpin motif. Upon binding, theribozymes cleave the target stromelysin encoding mRNAs, preventingtranslation and stromelysin protein accumulation. In the absence of theexpression of the target gene, a therapeutic effect may be observed.

By "inhibit" is meant that the activity or level of stromelysin encodingmRNAs and protein is reduced below that observed in the absence of theribozyme, and preferably is below that level observed in the presence ofan inactive RNA molecule able to bind to the same site on the mRNA, butunable to cleave that RNA.

Such ribozymes are useful for the prevention of the diseases andconditions discussed above, and any other diseases or conditions thatare related to the level of stromelysin activity in a cell or tissue. By"related" is meant that the inhibition of stromelysin mRNAs and thusreduction in the level of stromelysin activity will relieve to someextent the symptoms of the disease or condition.

Ribozymes are added directly, or can be complexed with cationic lipids,packaged within liposomes, or otherwise delivered to target cells. TheRNA or RNA complexes can be locally administered to relevant tissues exvivo, or in vivo through injection, aerosol inhalation, infusion pump orstent, with or without their incorporation in biopolymers. In preferredembodiments, the ribozymes have binding arms which are complementary tothe sequences in Tables II, III, IV, VI, VIII and IX. Examples of suchribozymes are shown in Tables V, VII, VIII and IX. Examples of suchribozymes consist essentially of sequences defined in these Tables.

By "consists essentially of" is meant that the active ribozyme containsan enzymatic center equivalent to those in the examples, and bindingarms able to bind mRNA such that cleavage at the target site occurs.Other sequences may be present which do not interfere with suchcleavage.

In another aspect of the invention, ribozymes that cleave targetmolecules and inhibit stromelysin activity are expressed fromtranscription units inserted into DNA or RNA vectors. The recombinantvectors are preferably DNA plasmids or viral vectors. Ribozymeexpressing viral vectors could be constructed based on, but not limitedto, adeno-associated virus, retrovirus, adenovirus, or alphavirus.Preferably, the recombinant vectors capable of expressing the ribozymesare delivered as described above, and persist in target cells.Alternatively, viral vectors may be used that provide for transientexpression of ribozymes. Such vectors might be repeatedly administeredas necessary. Once expressed, the ribozymes cleave the target mRNA.Delivery of ribozyme expressing vectors could be systemic, such as byintravenous or intramuscular administration, by administration to targetcells ex-planted from the patient followed by reintroduction into thepatient, or by any other means that would allow for introduction intothe desired target cell.

By "vectors" is meant any nucleic acid- and/or viral-based techniqueused to deliver a desired nucleic acid.

This class of chemicals exhibits a high degree of specificity forcleavage of the intended target mRNA. Consequently, the ribozyme agentwill only affect cells expressing that particular gene, and will not betoxic to normal tissues.

The invention can be used to treat or prevent (prophylactically)osteoarthritis or other pathological conditions which are mediated bymetalloproteinase activation. The preferred administration protocol isin vivo administration to reduce the level of stromelysin activity.

Thus, in the first aspect, the invention features an enzymatic RNAmolecule (or ribozyme) which cleaves mRNA associated with development ormaintenance of an arthritic condition, e.g., mRNA encoding stromelysin,and in particular, those mRNA targets disclosed in the tables below,which include both hammerhead and hairpin target sites. In each case thesite is flanked by regions to which appropriate substrate binding armscan be synthesized and an appropriate hammerhead or hairpin motif can beadded to provide enzymatic activity, by methods described herein andknown in the art. For example, referring to FIG. 1, arms I and III aremodified to be specific substrate-binding arms, and arm II remainsessentially as shown.

Ribozymes that cleave stromelysin mRNAs represent a novel therapeuticapproach to arthritic disorders like osteoarthritis. The inventionfeatures use of ribozymes to treat osteoarthritis, e.g., by inhibitingthe synthesis of prostromelysin molecule in synovial cells or by theinhibition of matrix metalloproteinases. Applicant indicates thatribozymes are able to inhibit the secretion of stromelysin and that thecatalytic activity of the ribozymes is required for their inhibitoryeffect. Those of ordinary skill in the art, will find that it is clearfrom the examples described that other ribozymes that cleave stromelysinencoding mRNAs may be readily designed and are within the invention.

In preferred embodiments, the enzymatic RNA molecule is formed in ahammerhead motif, but may also be formed in the motif of a hairpin,hepatitis delta virus, group I intron or RNAseP-like RNA (in associationwith an RNA guide sequence). Examples of such hammerhead motifs aredescribed by Rossi et al., 8 Aids Research and Human Retroviruses 183,1992, of hairpin motifs by Hampel et al., "RNA Catalyst for CleavingSpecific RNA Sequences", filed Sep. 20, 1989, which is acontinuation-in-part of U.S. Ser. No. 07/247,100, filed Sept. 20, 1988;Hampel and Tritz, 28 Biochemistry 4929, 1989; and Hampel et al., 18Nucleic Acids Research 299, 1990, and an example of the hepatitis deltavirus motif is described by Perrotta and Been, 31 Biochemistry 16, 1992,of the RNAseP motif by Guerrier-Takada, et al., 35 Cell 849, 1983, andof the group I intron by Cech et al., U.S. Pat. No. 4,987,071. All thepublications are hereby incorporated by reference herein. These specificmotifs are not limiting in the invention and those skilled in the artwill recognize that all that is important in an enzymatic RNA moleculeof this invention is that ,it has a specific substrate binding sitewhich is complementary to one or more of the target gene RNA regions,and that it have nucleotide sequences within or surrounding thatsubstrate binding site which impart an RNA cleaving activity to themolecule.

In a second related aspect, the invention features a mammalian cellwhich includes an enzymatic RNA molecule as described above. Preferably,the mammalian cell is a human cell.

In a third related aspect, the invention features an expression vectorwhich includes nucleic acid encoding an enzymatic RNA molecule describedabove, located in the vector, e.g., in a manner which allows expressionof that enzymatic RNA molecule within a mammalian cell.

In a fourth related aspect, the invention features a method fortreatment of an arthritic condition by administering to a patient anenzymatic RNA molecule as described above.

The invention provides a class of chemical cleaving agents which exhibita high degree of specificity for the mRNA causative of an arthriticcondition. Such enzymatic RNA molecules can be delivered exogenously orendogenously to infected cells. In the preferred hammerhead motif thesmall size (less than 40 nucleotides, preferably between 32 and 36nucleotides in length) of the molecule allows the cost of treatment tobe reduced.

The enzymatic RNA molecules of this invention can be used to treatarthritic or prearthritic conditions. Such treatment can also beextended to other related genes in nonhuman primates. Affected animalscan be treated at the time of arthritic risk detection, or in aprophylactic manner. This timing of treatment will reduce the chance offurther arthritic damage.

Other features and advantages of the invention will be apparent from thefollowing description of the preferred embodiments thereof, and from theclaims.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The drawing will first briefly be described.

Drawing

FIG. 1 is a diagrammatic representation of the hammerhead ribozymedomain (SEQ ID NOS. 368 and 369) known in the art. Stem II can be ≧2base-pairs long.

FIG. 2a is a diagrammatic representation of the hammerhead ribozymedomain known in the art; FIG. 2b is a diagrammatic representation of thehammerhead ribozyme as divided by Uhlenbeck (1987, Nature, 327, 596-600)into a substrate and enzyme portion; FIG. 2c is a similar diagramshowing the hammerhead divided by Haseloff and Gerlach (1988, Nature,334, 585-591) into two portions; and FIG. 2d is a similar diagramshowing the hammerhead divided by Jeffries and Symons (1989, Nucl.Acids. Res., 17, 1371-1371) into two portions.

FIG. 3 is a diagrammatic representation of the general structure of ahairpin ribozyme (SEQ ID NO. 371) and substrate RNA (SEQ ID NO. 370).Helix 2 (H2) is provided with a least 4 base pairs (i.e., n is 1, 2, 3or 4) and helix 5 can be optionally provided of length 2 or more bases(preferably 3-20 bases, i.e., m is from 1-20 or more). Helix 2 and helix5 may be covalently linked by one or more bases (i.e., r is ≧1 base).Helix 1, 4 or 5 may also be extended by 2 or more base pairs (e.g., 4-20base pairs) to stabilize the ribozyme structure, and preferably is aprotein binding site. In each instance, each N and N' independently isany normal or modified base and each dash represents a potentialbase-pairing interaction. These nucleotides may be modified at thesugar, base or phosphate. Complete base-pairing is not required in thehelices, but is preferred. Helix 1 and 4 can be of any size (i.e., o andp is each independently from 0 to any number, e.g., 20) as long as somebase-pairing is maintained. Essential bases are shown as specific basesin the structure, but those in the art will recognize that one or moremay be modified chemically (abasic, base, sugar and/or phosphatemodifications) or replaced with another base without significant effect.Helix 4 can be formed from two separate molecules, i.e., without aconnecting loop. The connecting loop when present may be aribonucleotide with or without modifications to its base, sugar orphosphate. "q" is ≧2 bases. The connecting loop can also be replacedwith a non-nucleotide linker molecule. H, refers to bases A, U or C. Yrefers to pyrimidine bases. "--" refers to a chemical bond.

FIG. 4 is a representation of the general structure of the hepatitisdelta virus ribozyme domain (SEQ ID NO. 372) known in the art.

FIG. 5 is a representation of the general structure of the self-cleavingVS RNA ribozyme domain (SEQ ID NO. 373).

FIG. 6 is a schematic representation of an RNAseH accessibility assay.Specifically, the left side of FIG. 6 is a diagram of complementary DNAoligonucleotides bound to accessible sites on the target RNA.Complementary DNA oligonucleotides are represented by broad lineslabeled A, B, and C. Target RNA is represented by the thin, twistedline. The right side of FIG. 6 is a schematic of a gel separation ofuncut target RNA from a cleaved target RNA. Detection of target RNA isby autoradiography of body-labeled, T7 transcript. The bands common toeach lane represent uncleaved target RNA; the bands unique to each lanerepresent the cleaved products.

FIG. 7 shows in vitro cleavage of stromelysin mRNA by HH ribozymes.

FIG. 8 shows inhibition of stromelysin expression by 21HH ribozyme inHS-27 fibroblast cell line.

FIG. 9 shows inhibition of stromelysin expression by 463HH ribozyme inHS-27 fibroblast cell line.

FIG. 10 shows inhibition of stromelysin expression by 1049HH ribozyme inHS-27 fibroblast cell line.

FIG. 11 shows inhibition of stromelysin expression by 1366HH ribozyme inHS-27 fibroblast cell line.

FIG. 12 shows inhibition of stromelysin expression by 1410HH ribozyme inHS-27 fibroblast cell line.

FIG. 13 shows inhibition of stromelysin expression by 1489HH ribozyme inHS-27 fibroblast cell line.

FIG. 14 shows 1049HH ribozyme-mediated reduction in the level ofstromelysin mRNA in rabbit knee.

FIG. 15 shows 1049HH ribozyme-mediated reduction in the level ofstromelysin mRNA in rabbit knee.

FIG. 16 shows 1049HH ribozyme-mediated reduction in the level ofstromelysin mRNA in rabbit knee.

FIG. 17 shows the effect of phosphorthioate substitutions on thecatalytic activity of 1049 2'-C-allyl HH ribozyme. A) diagrammaticrepresentation of 1049 hammerhead ribozyme•substrate complex (SEQ IDNOS. 1140 and 1139). 1049 U4-C-allyl P═S ribozyme represents ahammerhead containing ribose residues at five positions. The remaining31 nucleotide positions contain 2'-hydroxyl group substitutions, wherein30 nucleotides contain 2'-O-methyl substitutions and one nucleotide (U₄)contains 2'-C-allyl substitution. Additionally, five nucleotides withinthe ribozyme, at the 5' and 3' termini, contain phosphorothioatesubstitutions. B) shows the ability of ribozyme described in FIG. 17A todecrease the level of stromelysin RNA in rabbit knee.

FIG. 18 is a diagrammatic representation of chemically modifiedribozymes targeted against stromelysin RNA. 1049 2'-amino P═S Ribozyme(SEQ ID NOS. 1141 and 1142) represents a hammerhead containing riboseresidues at five positions. The remaining 31 nucleotide positionscontain 2'-hydroxyl group substitutions, wherein 29 nucleotides contain2'-O-methyl substitutions and two nucleotides (U₄ and U₇) contain2'-amino substitution. Additionally, the 3' end of this ribozymecontains a 3'-3' linked inverted T and four nucleotides at the 5'termini contain phosphorothioate substitutions. Arrowhead indicates thesite of RNA cleavage (site 1049). 1363 2'-Amino P═S (SEQ ID NOS. 1143and 1144). Human and Rabbit 1366 2'-Amino P═S (SEQ ID NOS. 1145-1148)ribozymes are identical to the 1049 2'-amino P═S ribozyme except thatthey are targeted to sites 1363 and 1366 within stromelysin RNAs.

FIG. 19 shows 1049 2'-amino P═S ribozyme-mediated reduction in the levelof stromelysin mRNA in rabbit knee.

FIG. 20 shows 1363 2'-amino P═S ribozyme-mediated reduction in the levelof stromelysin mRNA in rabbit knee.

FIG. 21 shows 1366 2'-amino P═S ribozyme-mediated reduction in the levelof stromelysin mRNA in rabbit knee.

RIBOZYMES

Ribozymes of this invention block to some extent stromelysin expressionand can be used to treat disease or diagnose such disease. Ribozymes aredelivered to cells in culture and to cells or tissues in animal modelsof osteoarthritis (Hembry et al., 1993 Am. J. Pathol. 143, 628).Ribozyme cleavage of stromelysin encoding mRNAs in these systems mayprevent inflammatory cell function and alleviate disease symptoms.

Target sites

Targets for useful ribozymes can be determined as disclosed in Draper etal supra, Sullivan et al., supra, as well as by Draper et al., "Methodand reagent for treatment of arthritic conditions U.S. Ser. No.08/152,487, filed Nov. 12, 1993, and hereby incorporated by referenceherein in totality. Rather than repeat the guidance provided in thosedocuments here, below are provided specific examples of such methods,not limiting to those in the art. Ribozymes to such targets are designedas described in those applications and synthesized to be tested in vitroand in vivo, as also described. Such ribozymes can also be optimized anddelivered as described therein. While specific examples to mouse andhuman RNA are provided, those in the art will recognize that theequivalent human RNA targets described can be used as described below.Thus, the same target may be used, but binding arms suitable fortargeting human RNA sequences are present in the ribozyme. Such targetsmay also be selected as described below.

The sequence of human and rabbit stromelysin mRNA were screened foraccessible sites using a computer folding algorithm. Potentialhammerhead or hairpin ribozyme cleavage sites were identified. Thesesites are shown in Tables II, III, IV, VI, VIII and IX (All sequencesare 5' to 3' in the tables.). While rabbit and human sequences can bescreened and ribozymes thereafter designed, the human targeted sequencesare of most utility. However, as discussed in Stinchcomb et al., "Methodand Composition for Treatment of Restenosis and Cancer Using Ribozymes,"filed May 18, 1994, U.S. Ser. No. 08/245,466, rabbit targeted ribozymesare useful to test efficacy of action of the ribozyme prior to testingin humans. The nucleotide base position is noted in the Tables as thatsite to be cleaved by the designated type of ribozyme.

Hammerhead or hairpin ribozymes are designed that could bind and areindividually analyzed by computer folding (Jaeger et al., 1989 Proc.Natl. Acad. Sci. USA, 86, 7706-7710) to assess whether the ribozymesequences fold into the appropriate secondary structure. Those ribozymeswith unfavorable intramolecular interactions between the binding armsand the catalytic core are eliminated from consideration. Varyingbinding arm lengths can be chosen to optimize activity. Generally, atleast 5 bases on each arm are able to bind to, or otherwise interactwith, the target RNA.

Referring to FIG. 6, mRNA is screened for accessible cleavage sites bythe method described generally in McSwiggen, U.S. patent applicationSer. No. 07/883,849 filed on May 1, 1992, entitled "Assay for ribozymetarget site", hereby incorporated by reference herein. Briefly, DNAoligonucleotides representing potential hammerhead or hairpin ribozymecleavage sites are synthesized. A polymerase chain reaction is used togenerate a substrate for T7 RNA polymerase transcription from human orrabbit stromelysin cDNA clones. Labeled RNA transcripts are synthesizedin vitro from the two templates. The oligonucleotides and the labeledtranscripts are annealed, RNAseH is added and the mixtures are incubatedfor the designated times at 37° C. Reactions are stopped and RNAseparated on sequencing polyacrylamide gels. The percentage of thesubstrate cleaved is determined by autoradiographic quantitation using aPhosphor Imaging system. From these data, hammerhead ribozyme sites arechosen as the most accessible.

Ribozymes of the hammerhead or hairpin motif are designed to anneal tovarious sites in the mRNA message. The binding arms are complementary tothe target site sequences described above. The ribozymes are chemicallysynthesized. The method of synthesis used follows the procedure fornormal RNA synthesis as described in Usman et al., 1987 J. Am. Chem.Soc., 109, 7845-7854 and in Scaringe et al., 1990 Nucleic Acids Res.,18, 5433-5441 and makes use of common nucleic acid protecting andcoupling groups, such as dimethoxytrityl at the 5'-end, andphosphoramidites at the 3'-end. The average stepwise coupling yieldswere >98%. Inactive ribozymes were synthesized by substituting a U forG₅ and a U for A₁₄ (numbering from Hertel et al., 1992 Nucleic AcidsRes., 20, 3252). Hairpin ribozymes are synthesized in two parts andannealed to reconstruct the active ribozyme (Chowrira and Burke, 1992Nucleic Acids Res., 20, 2835-2840). All ribozymes are modifiedextensively to enhance stability by modification with nuclease resistantgroups, for example, 2'-amino, 2'-C-allyl, 2'-flouro, 2'-o-methyl, 2'-H(for a review see Usman and Cedergren, 1992 TIBS 17, 34). Ribozymes arepurified by gel electrophoresis using general methods or are purified byhigh pressure liquid chromatography (HPLC; See Usman et al., Synthesis,deprotection, analysis and purification of RNA and ribozymes, filed May,18, 1994, U.S. Ser. No. 08/245,736 the totality of which is herebyincorporated herein by reference) and are resuspended in water.

The sequences of the chemically synthesized ribozymes useful in thisstudy are shown in Tables V, VII, VIII and IX. Those in the art willrecognize that these sequences are representative only of many more suchsequences where the enzymatic portion of the ribozyme (all but thebinding arms) is altered to affect activity. For example, stem loop IIsequence of hammerhead ribozymes listed in Tables V and VII(5'-GGCCGAAAGGCC-3') can be altered (substitution, deletion and/orinsertion) to contain any sequence provided, a minimum of twobase-paired stem structure can form. Similarly, stem-loop IV sequence ofhairpin ribozymes listed in Tables VI and VII (5'-CACGUUGUG-3') can bealtered (substitution, deletion and/or insertion) to contain anysequence provided, a minimum of two base-paired stem structure can form.The sequences listed in Tables V, VII, VIII and IX may be formed ofribonucleotides or other nucleotides or non-nucleotides. Such ribozymesare equivalent to the ribozymes described specifically in the Tables.

Optimizing Ribozyme Activity

Ribozyme activity can be optimized as described by Stinchcomb et al.,supra. The details will not be repeated here, but include altering thelength of the ribozyme binding arms (stems I and III, see FIG. 2c), orchemically synthesizing ribozymes with modifications that prevent theirdegradation by serum ribonucleases (see e.g., Eckstein et al.,International Publication No. WO 92/07065; Perrault et al., 1990 Nature344, 565; Pieken et al., 1991 Science 253, 314; Usman and Cedergren,1992 Trends in Biochem. Sci. 17, 334; Usman et al., InternationalPublication No. WO 93/15187; and Rossi et al., International PublicationNo. WO 91/03162, as well as Usman, N. et al., U.S. patent applicationSer. No. 07/829,729, Sproat, European Patent Application 92110298.4 andU.S. Pat. No. 5,334,711 and Jennings et al., WO 94/13688 which describevarious chemical modifications that can be made to the sugar moieties ofenzymatic RNA molecules. All these publications are hereby incorporatedby reference herein.), modifications which enhance their efficacy incells, and removal of stem II bases to shorten RNA synthesis times andreduce chemical requirements.

Sullivan, et al., supra, describes the general methods for delivery ofenzymatic RNA molecules. Ribozymes may be administered to cells by avariety of methods known to those familiar to the art, including, butnot restricted to, encapsulation in liposomes, by iontophoresis, or byincorporation into other vehicles, such as hydrogels, cyclodextrins,biodegradable nanocapsules, and bioadhesive microspheres. For someindications, ribozymes may be directly delivered ex vivo to cells ortissues with or without the aforementioned vehicles. Alternatively, theRNA/vehicle combination is locally delivered by direct inhalation, bydirect injection or by use of a catheter, infusion pump or stent. Otherroutes of delivery include, but are not limited to, intravascular,intramuscular, subcutaneous or joint injection, aerosol inhalation, oral(tablet or pill form), topical, systemic, ocular, intraperitoneal and/orintrathecal delivery. More detailed descriptions of ribozyme deliveryand administration are provided in Sullivan et al., supra and Draper etal., supra which have been incorporated by reference herein.

Another means of accumulating high concentrations of a ribozyme(s)within cells is to incorporate the ribozyme-encoding sequences into aDNA expression vector. Transcription of the ribozyme sequences aredriven from a promoter for eukaryotic RNA polymerase I (pol I), RNApolymerase II (pol II), or RNA polymerase III (pol III). Transcriptsfrom pol II or pol III promoters will be expressed at high levels in allcells; the levels of a given pol II promoter in a given cell type willdepend on the nature of the gene regulatory sequences (enhancers,silencers, etc.) present nearby. Prokaryotic RNA polymerase promotersare also used, providing that the prokaryotic RNA polymerase enzyme isexpressed in the appropriate cells (Elroy-Stein and Moss, 1990 Proc.Natl. Acad. Sci. USA, 87, 6743-7; Gao and Huang 1993 Nucleic Acids Res.,21, 2867-72; Lieber et al., 1993 Methods Enzymol., 217, 47-66; Zhou etal., 1990 Mol. Cell. Bio., 10, 4529-37). Several investigators havedemonstrated that ribozymes expressed from such promoters can functionin mammalian cells (e.g. Kashani-Sabet et al., 1992 Antisense Res. Dev.,2, 3-15; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA, 89, 10802-6;Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Yu et al., 1993 Proc.Natl. Acad. Sci. USA, 90, 6340-4; L'Huillier et al., 1992 EMBO J. 11,4411-8; Lisziewicz et al., 1993 Proc. Natl. Acad. Sci. U.S.A., 90,8000-4). The above ribozyme transcription units can be incorporated intoa variety of vectors for introduction into mammalian cells, includingbut not restricted to, plasmid DNA vectors, viral DNA vectors (such asadenovirus or adeno-associated vectors), or viral RNA vectors (such asretroviral or alphavirus vectors).

In a preferred embodiment of the invention, a transcription unitexpressing a ribozyme that cleaves stromelysin RNA is inserted into aplasmid DNA vector or an adenovirus DNA virus or adeno-associated virus(AAV) vector. Both viral vectors have been used to transfer genes to thelung and both vectors lead to transient gene expression (Zabner et al.,1993 Cell 75, 207; Carter, 1992 Curr. Opi. Biotech. 3, 533). Theadenovirus vector is delivered as recombinant adenoviral particles. TheDNA may be delivered alone or complexed with vehicles (as described forRNA above). The recombinant adenovirus or AAV particles are locallyadministered to the site of treatment, e.g., through incubation orinhalation in vivo or by direct application to cells or tissues ex vivo.

EXAMPLE 1

Stromelysin Hammerhead ribozymes

By engineering ribozyme motifs applicant has designed several ribozymesdirected against stromelysin mRNA sequences. These ribozymes aresynthesized with modifications that improve their nuclease resistance.The ability of ribozymes to cleave stromelysin target sequences in vitrois evaluated.

The ribozymes are tested for function in vivo by analyzing stromelysinexpression levels. Ribozymes are delivered to cells by incorporationinto liposomes, by complexing with cationic lipids, by microinjection,and/or by expression from DNA/RNA vectors. Stromelysin expression ismonitored by biological assays, ELISA, by indirect immunofiuoresence,and/or by FACS analysis, Stromelysin mRNA levels are assessed byNorthern analysis, RNAse protection, primer extension analysis and/orquantitative RT-PCR. Ribozymes that block the induction of stromelysinactivity and/or stromelysin mRNA by more than 50% are identified.

Ribozymes targeting selected regions of mRNA associated with arthriticdisease are chosen to cleave the target RNA in a manner which preferablyinhibits translation of the RNA. Genes are selected such that inhibitionof translation will preferably inhibit cell replication, e.g., byinhibiting production of a necessary protein or prevent production of anundesired protein, e.g., stromelysin. Selection of effective targetsites within these critical regions of mRNA may entail testing theaccessibility of the target RNA to hybridization with variousoligonucleotide probes. These studies can be performed using RNA or DNAprobes and assaying accessibility by cleaving the hybrid molecule withRNAseH (see below and McSwiggen, Assay for Ribozyme Target SiteAccessibility, U.S. Ser. No. 07/884,073, filed May 14, 1992, herebyincorporated by reference herein). Alternatively, such a study can useribozyme probes designed from secondary structure predictions of themRNAs, and assaying cleavage products by polyacrylamide gelelectrophoresis (PAGE), to detect the presence of cleaved and uncleavedmolecules.

In addition, potential ribozyme target sites within the rabbitstromelysin mRNA sequence (1795 nucleotides) were located and alignedwith the human target sites. Because the rabbit stromelysin mRNAsequence has an 84% sequence identity with the human sequence, manyribozyme target sites are also homologous. Thus, the rabbit haspotential as an appropriate animal model in which to test ribozymes thatare targeted to human stromelysin but have homologous or nearlyhomologous cleavage sites on rabbit stromelysin mRNA as well (TablesII-VI, VIII & IX ). Thirty of the 316 UH sites in the rabbit sequenceare identical with the corresponding site in the human sequence withrespect to at least 14 nucleotides surrounding the potential ribozymecleavage sites. The nucleotide in the RNA substrate that is immediatelyadjacent (5') to the cleavage site is unpaired in the ribozyme-substratecomplex (see FIG. 1) and is consequently not included in the comparisonof human and rabbit potential ribozyme sites. In choosing human ribozymetarget sites for continued testing, the presence of identical or nearlyidentical sites in the rabbit sequence is considered.

EXAMPLE 2

Superior sites

Potential ribozyme target sites were subjected to further analysis usingcomputer folding programs (Mulfold or a Macintosh-based version of thefollowing program, LRNA (Zucker (1989) Science 244:48), to determineif 1) the target site is substantially single-stranded and thereforepredicted to be available for interaction with a ribozyme, 2) if aribozyme designed to that site is predicted to form stem II but isgenerally devoid of any other intramolecular base pairing, and 3) if thepotential ribozyme and the sequence flanking both sides of the cleavagesite together are predicted to interact correctly. The sequence of StemII can be altered to maintain a stem at that position but minimizeintramolecular basepairing with the ribozyme's substrate binding arms.Based on these minimal criteria, and including all the sites that areidentical in human and rabbit stromelysin mRNA sequence, a subset of 66potential superior ribozyme target sites was chosen (as first roundtargets) for continued analysis. These are SEQ. ID. NOS.: 34, 35, 37,47, 54, 57, 61, 63, 64, 66, 76, 77, 79, 87, 88, 96, 97, 98, 99, 100,107, 110, 121, 126, 128, 129, 133, 140, 146, 148, 151, 162, 170, 179,188, 192, 194, 196, 199, 202, 203, 207, 208, 218, 220, 223, 224, 225,227, 230, 232, 236, 240, 245, 246, 256, 259, 260, 269, 280, 281, 290,302, 328, 335 and 353 (see Table III).

EXAMPLE 3

Accessible sites

To determine if any or all of these potential superior sites might beaccessible to a ribozyme directed to that site, an RNAse H assay iscarried out (described in more detail in McSwiggen, U.S. Ser. Nos.07/883,849 and 07/884,073 both filed May 14, 1992 and herebyincorporated by reference herein). Using this assay, the accessibilityof a potential ribozyme target site to a DNA oligonucleotide probe canbe assessed without having to synthesize a ribozyme to that particularsite. If the complementary DNA oligonucleotide is able to hybridize tothe potential ribozyme target site then RNAse H, which has the abilityto cleave the RNA of a DNA/RNA hybrid, will be able to cleave the targetRNA at that particular site. Specific cleavage of the target RNA byRNAse H is an indication that that site is "open" or "accessible" tooligonucleotide binding and thus predicts that the site will also beopen for ribozyme binding. By comparing the relative amount of specificRNAse H cleavage products that are generated for each DNAoligonucleotide/site, potential ribozyme sites can be ranked accordingto accessibility.

To analyze target sites using the RNAse H assay, DNA oligonucleotides(generally 13-15 nucleotides in length) that are complementary to thepotential target sites are synthesized. Body-labeled substrate RNAs(either full-length RNAs or ˜500-600 nucleotide subfragments of theentire RNA) are prepared by in vitro transcription in the presence of a³² P-labeled nucleotide. Unincorporated nucleotides are removed from the³² P-labeled substrate RNA by spin chromatography on a G-50 Sephadexcolumn and used without further purification. To carry out the assay,the ³² P-labeled substrate RNA is pre-incubated with the specific DNAoligonucleotide (1 μM and 0.1 μM final concentration) in 20 mM Tris-HCl,pH 7.9, 100 mM KCl, 10 mM MgCl₂, 0.1 mM EDTA, 0.1 mM DTT at 37° C. for 5minutes. An excess of RNAse H (0.8 units/10 μl reaction) is added andthe incubation is continued for 10 minutes. The reaction is quenched bythe addition of an equal volume of 95% formamide, 20 mM EDTA, 0.05%bromophenol blue and 0.05% xylene cyanol FF after which the sample isheated to 95° C. for 2 minutes, quick chilled and loaded onto adenaturing polyacrylamide gel. RNAse H-cleaved RNA products areseparated from uncleaved RNA on denaturing polyacrylamide gels,visualized by autoradiography and the amount of cleavage product isquantified.

RNAse H analysis on the 66 potential ribozyme sites (round 1 ) wascarried out and those DNA oligonucleotides/sites that supported the mostRNAse H cleavage were determined. These assays were carried out usingfull-length human and rabbit stromelysin RNA as substrates. Resultsdetermined on human stromelysin RNA indicated that 23 of the 66 sitessupported a high level of RNAse H cleavage, and an additional 13supported a moderate level of RNAse H cleavage. Twenty-two sites werechosen from among these two groups for continued study. Two of thecriteria used for making this choice were 1) that the particular sitesupported at least moderate RNAse H cleavage on human stromelysin RNAand 2) that the site have two or fewer nucleotide differences betweenthe rabbit and the human stromelysin sequence. RNAse H accessibility onrabbit stromelysin RNA was determined, but was not used as a specificcriteria for these choices. Those DNA oligonucleotides that are nottotally complementary to the rabbit sequence may not be good indicatorsof the relative amount of RNAse H cleavage, possibly because themismatch leads to less efficient hybridization of the DNAoligonucleotide to the mismatched RNA substrate and therefore less RNAseH cleavage is seen.

EXAMPLE 4

Analysis of Ribozymes

Ribozymes were then synthesized to 22 sites (Table V) predicted to beaccessible as judged the RNAse H assay. Eleven of these 22 sites areidentical to the corresponding rabbit sites. The 22 sites are SEQ. ID,NOS.: 34, 35, 57, 125, 126, 127, 128, 129, 140, 162, 170, 179, 188, 223,224, 236, 245, 246, 256, 259, 260, 281. The 22 ribozymes were chemicallysynthesized with recognition arms of either 7 nucleotides or 8nucleotides, depending on which ribozyme alone and ribozyme-substratecombinations were predicted by the computer folding program (Mulfold) tofold most correctly. After synthesis, ribozymes are either purified byHPLC or gel purified.

These 22 ribozymes were then tested for their ability to cleave bothhuman and rabbit full-length stromelysin RNA. Full-length, body-labeledstromelysin RNA is prepared by in vitro transcription in the presence ofα-³² P!CTP, passed over a G 50 Sephadex column by spin chromatographyand used as substrate RNA without further purification. Assays areperformed by prewarming a 2× concentration of purified ribozyme inribozyme cleavage buffer (50 mM Tris-HCl, pH 7.5 at 37° C., 10 mM MgCl₂)and the cleavage reaction is initiated by adding the 2× ribozyme mix toan equal volume of substrate RNA (maximum of 1-5 nM) that has also beenprewarmed in cleavage buffer. As an initial screen, assays are carriedout for 1 hour at 37° C. using a final concentration of 1 μM and 0.1 μMribozyme, i.e., ribozyme excess. The reaction is quenched by theaddition of an equal volume of 95% formamide, 20 mM EDTA, 0.05%bromophenol blue and 0.05% xylene cyanol FF after which the sample isheated to 95° C. for 2 minutes, quick chilled and loaded onto adenaturing polyacrylamide gel. Full-length substrate RNA and thespecific RNA products generated by ribozyme cleavage are visualized onan autoradiograph of the gel.

Of the 22 ribozymes tested, 21 were able to cleave human and rabbitsubstrate RNA in vitro in a site-specific manner. In all cases, RNAcleavage products of the appropriate lengths were visualized. The sizeof the RNA was judged by comparison to molecular weight standardselectrophoresed in adjacent lanes of the gel. The fraction of substrateRNA cleaved during a ribozyme reaction can be used as an assessment ofthe activity of that ribozyme in vitro. The activity of these 22ribozymes on full-length substrate RNA ranged from approximately 10% togreater than 95% of the substrate RNA cleaved in the ribozyme cleavageassay using 1 μM ribozyme as described above. A subset of seven of theseribozymes was chosen for continued study. These seven ribozymes (denotedin Table V) were among those with the highest activity on both human andrabbit stromelysin RNA. Five of these seven sites have sequence identitybetween human and rabbit stromelysin RNAs for a minimum of 7 nucleotidesin both directions flanking the cleavage site. These sites are 883, 947,1132, 1221 and 1410. and the ribozymes are SEQ. ID. NOS.: 368, 369, 370,371, 372, 373, and 374.

EXAMPLE 5

Arm Length Tests

In order to test the effect of arm length variations on the cleavageactivity of a ribozyme to a particular site in vitro, ribozymes to theseseven sites were designed that had alterations in the binding armlengths. For each site, a complete set of ribozymes was synthesized thatincluded ribozymes with binding arms of 6 nucleotides, 7 nucleotides, 8nucleotides, 10 nucleotides and 12 nucleotides, i.e., 5 ribozymes toeach site. These ribozymes were gel-purified after synthesis and testedin ribozyme cleavage assays as described above.

After analysis of the 35 ribozymes, five ribozymes with varied armlengths to each of these seven sites, it was clear that two ribozymeswere the most active in vitro. These two ribozymes had seven nucleotidearms directed against human sequence cleavage sites of nucleotide 617and nucleotide 820. These are referred to as RZ 617H 7/7 and RZ 820H 7/7denoting the human (H) sequence cleavage site (617 or 820) and the armlength on the 5' and 3' side of the ribozyme molecule.

EXAMPLE 6

Testing the efficacy of ribozymes in cell culture

The two most active ribozymes in vitro (RZ 617H 7/7 and RZ 820H 7/7)were then tested for their ability to cleave stromelysin mRNA in thecell. Primary cultures of human or rabbit synovial fibroblasts were usedin these experiments. For these efficacy tests, ribozymes with 7nucleotide arms were synthesized with 2' O-methyl modifications on the 5nucleotides at the 5' end of the molecule and on the 5 nucleotides atthe 3' end of the molecule. For comparison, ribozymes to the same sitesbut with 12 nucleotide arms (RZ 617H 12/12 and RZ 820H 12/12) were alsosynthesized with the 2' O methyl modifications at the 5 positions at theend of both binding arms. Inactive ribozymes that contain 2 nucleotidechanges in the catalytic core region were also prepared for use ascontrols. The catalytic core in the inactive ribozymes isCUUAUGAGGCCGAAAGGCCGAU versus CUGAUGAGGCCGAAAGGCCGAA in the activeribozymes. The inactive ribozymes show no cleavage activity in vitrowhen measured on full-length RNA in the typical ribozyme cleavage assayat a 1 μM concentration for 1 hour.

The general assay was as follows: Fibroblasts, which producestromelysin, are serum-starved overnight and ribozymes or controls areoffered to the cells the next day. Cells are maintained in serum-freemedia. The ribozyme can be applied to the cells as free ribozyme, or inassociation with various delivery vehicles such as cationic lipiris(including Transfectam™, Lipofectin™ and Lipofectamine™), conventionalliposomes, non-phospholipid liposomes or biodegradable polymers. At thetime of ribozyme addition, or up to 3 hours later, Interleukin-1α(typically 20 units/ml) can be added to the cells to induce a largeincrease in stromelysin expression. The production of stromelysin canthen be monitored over a time course, usually up to 24 hours.

If a ribozyme is effective in cleaving stromelysin mRNA within a cell,the amount of stromelysin mRNA will be decreased or eliminated. Adecrease in the level of cellular stromelysin mRNA, as well as theappearance of the RNA products generated by ribozyme cleavage of thefull-length stromelysin mRNA, can be analyzed by methods such asNorthern blot analysis, RNAse protection assays and/or primer extensionassays. The effect of ribozyme cleavage of cellular stromelysin mRNA onthe production of the stromelysin protein can also be measured by anumber of assays. These include the ELISA (Enzyme-Linked Immuno SorbentAssay) and an immunofluorescence assay described below. In addition,functional assays have been published that monitor stromelysin'senzymatic activity by measuring degradation of its primary substrate,proteoglycan.

EXAMPLE 7

Analysis of Stromelysin Protein

Stromelysin secreted into the media of Interleukin-1α-induced humansynovial fibroblasts was measured by ELISA using an antibody thatrecognizes human stromelysin. Where present, a Transfectam™-ribozymecomplex (0.15 μM ribozyme final concentration) was offered to 2-4×10⁵serum-starved cells for 3 hours prior to induction with Interleukin-1α.The Transfectam™ was prepared according to the manufacturer (PromegaCorp.) except that 1:1 (w/w) dioleoyl phosphatidylethanolamine wasincluded. The Transfectam™-ribozyme complex was prepared in a 5:1 chargeratio. Media was harvested 24 hours after the addition ofInterleukin-1α. The control (NO RZ) is Transfectam™ alone applied to thecell. Inactive ribozymes, with 7 nucleotide arms or 12 nucleotide armshave the two inactivating changes to the catalytic core that aredescribed above. Cell samples were prepared in duplicate and the assaywas carried out on several dilutions of the conditioned media from eachsample. Results of the ELISA are presented below as a percent ofstromelysin present vs. the control (NO RZ) which is set at 100%.

    ______________________________________                                                         RZ TARGET SITE                                               TREATMENT          617H   820H                                                ______________________________________                                        RZ 7/7             06.83  07.05                                               RZ 12/12           18.47  33.90                                               INACTIVE RZ 7/7    100    100                                                 INACTIVE RZ 12/12  100    100                                                 NO RZ CONTROL      100    100                                                 ______________________________________                                    

The results above clearly indicate that treatment with active ribozyme,either RZ 617H 7/7 and RZ 820H 7/7, has a dramatic effect on the amountof stromelysin secreted by the cells. When compared to untreated,control cells or cells treated with inactive ribozymes, the level ofstromelysin was decreased by approximately 93%. Ribozymes to the samesites, but synthesized with 12 nucleotide binding arms, were alsoefficacious, causing a decrease in stromelysin to ˜66 to ˜81% of thecontrol. In previous in vitro ribozyme cleavage assays, RZ 617H 7/7 andRZ 820H 7/7 had better cleavage activity on full-length RNA substratesthan ribozymes with 12 nucleotide arms directed to the same sites (617H12/12 and RZ 820H 12/12).

EXAMPLE 8

Immunofluorescent Assay

An alternative method of stromelysin detection is to visualizestromelysin protein in the cells by immunofluorescence. For this assay,cells are treated with monensin to prevent protein secretion from thecell. The stromelysin retained by the cells after monensin addition canthen be visualized by immunofluorescence using either conventional orconfocal microscopy. Generally, cells were serum-starved overnight andtreated with ribozyme the following day for several hours. Monensin wasthen added and after ˜5-6 hours, monensin-treated cells were fixed andpermeabilized by standard methods and incubated with an antibodyrecognizing human stromelysin. Following an additional incubation periodwith a secondary antibody that is conjugated to a fluorophore, the cellswere observed by microscopy. A decrease in the amount of fluorescence inribozyme-treated cells, compared to cells treated with inactiveribozymes or media alone, indicates that the level of stromelysinprotein has been decreased due to ribozyme treatment.

As visualized by the immunofluorescence technique described above,treatment of human synovial fibroblasts with either RZ 617H 7/7 or RZ820H 7/7 (final concentrations of 1.5 μM free ribozyme or 0.15 μMribozyme complexed with Transfectam™ resulted in a significant decreasein fluorescence, and therefore stromelysin protein, when compared withcontrols. Controls consisted of treating with media or Transfectam™alone. Treatment of the cells with the corresponding inactive ribozymeswith two inactivating changes in the catalytic core resulted inimmunofluorescence similar to the controls without ribozyme treatment.

Rabbit synovial fibroblasts were also treated with RZ 617H 7/7 or RZ820H 7/7, as well as with the two corresponding ribozymes (RZ 617R 7/7or RZ 820R 7/7) that each have the appropriate one nucleotide change tomake them completely complementary to the rabbit target sequence.Relative to controls that had no ribozyme treatment, immunofluorescencein Interleukin-1α-induced rabbit synovial fibroblasts was visiblydecreased by treatment with these four ribozymes, whether specific forrabbit or human mRNA sequence. For the immunofluorescence study inrabbit synovial fibroblasts, the antibody to human stromelysin was used.

EXAMPLE 9

Ribozyme Cleavage of Cellular RNA

The following method was used in this example.

Primer extension assay:

The primer extension assay was used to detect full-length RNA as well asthe 3' ribozyme cleavage products of the RNA of interest. The methodinvolves synthesizing a DNA primer (generally ˜20 nucleotides in length)that can hybridize to a position on the RNA that is downstream (3') ofthe putative ribozyme cleavage site. Before use, the primer was labeledat the 5' end with ³² P ATP! using T4 polynucleotide kinase and purifiedfrom a gel. The labeled primer was then incubated with a population ofnucleic acid isolated from a cellular lysate by standard procedures. Thereaction buffer was 50 mM Tris-HCl, pH 8.3, 3 mM MgCl₂, 20 mM KCl, and10 mM DTT. A 30 minute extension reaction follows, in which all DNAprimers that have hybridized to the RNA were substrates for reversetranscriptase, an enzyme that will add nucleotides to the 3' end of theDNA primer using the RNA as a template. Reverse transcriptase wasobtained from Life Technologies and is used essentially as suggested bythe manufacturer. Optimally, reverse transcriptase will extend the DNAprimer, forming cDNA, until the end of the RNA substrate is reached.Thus, for ribozyme-cleaved RNA substrates, the cDNA product will beshorter than the resulting cDNA product of a full-length, or uncleavedRNA substrate. The differences in size of the ³² P-labeled cDNAsproduced by extension can then be discriminated by electrophoresis on adenaturing polyacrylamide gel and visualized by autoradiography.

Strong secondary structure in the RNA substrate can, however, lead topremature stops by reverse transcriptase. This background of shortercDNAs is generally not a problem unless one of these prematurelyterminated products electrophoreses in the expected position of theribozyme-cleavage product of interest. Thus, 3' cleavage products areeasily identified based on their expected size and their absence fromcontrol lanes. Strong stops due to secondary structure in the RNA do,however, cause problems in trying to quantify the total full-length andcleaved RNA present. For this reason, only the relative amount ofcleavage can easily be determined.

The primer extension assay was carried out on RNA isolated from cellsthat had been treated with Transfectam™-complexed RZ 617H 7/7, RZ 820H7/7, RZ 617H 12/12 and RZ 820H 12/12. Control cells had been treatedwith Transfectam™ alone. Primer extensions on RNA from cells treatedwith the Transfectam™ complexes of the inactive versions of these fourribozymes were also prepared. The 20 nucleotide primer sequence is 5'AATGAAAACGAGGTCCTTGC 3' and it is complementary to a region about 285nucleotides downstream of ribozyme site 820. For ribozymes to site 617,the cDNA length for the 3' cleavage product is 488 nucleotides, for 820the cDNA product is 285 nucleotides. Full-length cDNA will be 1105nucleotides in length. Where present, 1 ml of 0.15 μM ribozyme wasoffered to ˜2-3×10⁵ serum-starved human syncvial fibroblasts. After 3hours, 20 units/ml Interleukin-1α was added to the cells and theincubation continued for 24 hours.

³² P-labeled cDNAs of the correct sizes for the 3' products were clearlyvisible in lanes that contained RNA from cells that had been treatedwith active ribozymes to sites 617 and 820. Ribozymes with 7 nucleotidearms were judged to be more active than ribozymes with 12 nucleotidearms by comparison of the relative amount of 3' cleavage productvisible. This correlates well with the data obtained by ELISA analysisof the conditioned media from these same samples. In addition, no cDNAscorresponding to the 3' cleavage products were visible followingtreatment of the cells with any of the inactive ribozymes.

To insure that ribozyme cleavage of the RNA substrate was not occurringduring the preparation of the cellular RNA or during the primerextension reaction itself, several controls have been carried out. Onecontrol was to add body-labeled stromelysin RNA, prepared by in vitrotranscription, to the cellular lysate. This lysate was then subjected tothe typical RNA preparation and primer extension analysis except thatnon-radioactive primer was used. If ribozymes that are present in thecell at the time of cell lysis are active under any of the conditionsduring the subsequent analysis, the added, body-labeled stromelysin RNAwill become cleaved. This, however, is not the case. Only full-lengthRNA was visible by gel analysis, no ribozyme cleavage products werepresent. This is evidence that the cleavage products detected in RNAfrom ribozyme-treated cells resulted from ribozyme cleavage in the cell,and not during the subsequent analysis.

EXAMPLE 10

RNAse Protection Assay

By RNAse protection analysis, both the 3' and the 5' products generatedby ribozyme cleavage of the substrate RNA in a cell can be identified.The RNAse protection assay is carried out essentially as described inthe protocol provided with the Lysate Ribonuclease Protection Kit(United States Biochemical Corp.) The probe for RNAse protection is anRNA that is complementary to the sequence surrounding the ribozymecleavage site. This "antisense" probe RNA is transcribed in vitro from atemplate prepared by the polymerase chain reaction in which the 5'primer was a DNA oligonucleotide containing the T7 promoter sequence.The probe RNA is body labeled during transcription by including ³² PCTP! in the reaction and purified away from unincorporated nucleotidetriphosphates by chromatography on G-50 Sephadex. The probe RNA (100,000to 250,000 cpms) is allowed to hybridize overnight at 37° C. to the RNAfrom a cellular lysate or to RNA purified from a cell lysate. Afterhybridization, RNAse T₁ and RNAse A are added to degrade allsingle-stranded RNA and the resulting products are analyzed by gelelectrophoresis and autoradiography. By this analysis, full-length,uncleaved target RNA will protect the full-length probe. Forribozyme-cleaved target RNAs, only a portion of the probe will beprotected from RNAse digestion because the cleavage event has occurredin the region to which the probe binds. This results in two protectedprobe fragments whose size reflects the position at which ribozymecleavage occurs and whose sizes add up to the size of the full-lengthprotected probe.

RNAse protection analysis was carried out on cellular RNA isolated fromrabbit synovial fibroblasts that had been treated either with active orinactive ribozyme. The ribozymes tested had 7 nucleotide arms specificto the rabbit sequence but corresponding to human ribozyme sites 617 and820 (i.e. RZ 617R 7/7, RZ 820R 7/7). The inactive ribozymes to the samesites also had 7 nucleotide arms and included the two inactivatingchanges described above. The inactive ribozymes were not active onfull-length rabbit stromelysin RNA in a typical 1 hour ribozyme cleavagereaction in vitro at a concentration of 1 μM. For all samples, one ml of0.15 μM ribozyme was administered as a Transfectam™ complex toserum-starved cells. Addition of Interleukin-1α followed 3 hours laterand cells were harvested after 24 hours. For samples from cells treatedwith either active ribozyme tested, the appropriately-sized probefragments representing ribozyme cleavage products were visible. For site617, two fragments corresponding to 125 and 297 nucleotides werepresent, for site 820 the two fragments were 328 and 94 nucleotides inlength. No protected probe fragments representing RNA cleavage productswere visible in RNA samples from cells that not been treated with anyribozyme, or in cells that had received the inactive ribozymes.Full-length protected probe (422 nucleotides in length) was howevervisible, indicating the presence of full-length, uncleaved stromelysinRNA in these samples.

Delivery of Free and Transfectam-Complexed Ribozymes to Fibroblasts

Ribozymes can be delivered to fibroblasts complexed to a cationic lipidor in free form. To deliver free ribozyme, an appropriate dilution ofstock ribozyme (final concentration is usually 1.5 μM) is made inserum-free medium; if a radioactive tracer is to be used (i.e., ³² P),the specific activity of the ribozyme is adjusted to 800-1200 cpm/pmol.To deliver ribozyme complexed with the cationic lipid Transfectam, thelipid is first prepared as a stock solution containing 1/1 (w/w)dioleoylphosphatidylcholine (DOPE). Ribozyme is mixed with theTransfectam/DOPE mixture at a 1/5 (RZ/TF) charge ratio; for a 36-merribozyme, this is a 45-fold molar excess of Transfectam (Transfectam has4 positive charges per molecule). After a 10 min incubation at roomtemperature, the mixture is diluted and applied to cells, generally at aribozyme concentration of 0.15 μM. For ³² P experiments, the specificactivity of the ribozyme is the same as for the free ribozymeexperiments.

After 24 hour, about 30% of the offered Transfectam-ribozyme cpm's arecell-associated (in a nuclease-resistant manner). Of this, about 10-15%of the cpm's represent intact ribozyme; this is about 20-25 millionribozymes per cell. For the free ribozyme, about 0.6% of the offereddose is cell-associated after 24 hours. Of this, about 10-15% is intact;this is about 0.6-0.8 million ribozymes per cell.

EXAMPLE 11

In vitro cleavage of stromelysin mRNA by HH ribozymes

In order to screen for additional HH ribozyme cleavage sites, ribozymes,targeted against some of the sites listed in example 2 and Table 3, weresynthesized. These ribozymes were extensively modified such that: 5'terminal nucleotides contain phosphorothioate substitutions; except forfive ribose residues in the catalytic core, all the other 2'-hydroxylgroups within the ribozyme were substituted with either 2'-O-methylgroups or 2'-C-allyl modifications. The aforementioned modifications aremeant to be non-limiting modifications. Those skilled in the art willrecognize that other embodiments can be readily generated using thetechniques known in the art.

These ribozymes were tested for their ability to cleave RNA substratesin vitro. Referring to FIG. 7, in vitro RNA cleavage by HH ribozymestargeted to sites 21, 463, 1049, 1366, 1403, 1410 and 1489 (SEQ. ID.NOS. 35, 98, 202, 263, 279, 281 and 292 respectively) was assayed at 37°C. Substrate RNAs were 5' end-labeled using γ-³² P!ATP and T4polynucleotide kinase enzyme. In a standard cleavage reaction under"ribozyme excess" conditions, ˜1 nM substrate RNA and 40 nM ribozymewere denatured separately by heating to 90° C. for 2 min followed bysnap cooling on ice for 10 min. The substrate and the ribozyme reactionmixtures were renatured in a buffer containing 50 mM Tris-HCl, pH 7.5and 10 mM MgCl₂ at 37° C. for 10 min. Cleavage reaction was initiated bymixing the ribozyme and the substrate RNA and incubating at 37° C.Aliquots of 5 μl were taken at regular intervals of time and thereaction quenched by mixing with an equal volume of formamide stop mix.The samples were resolved on a 20% polyacrylamide/urea gel.

A plot of percent RNA substrate cleaved as a function of time is shownin FIG. 7. The plot shows that all six HH ribozymes cleaved the targetRNA efficiently. Some HH ribozymes were, however, more efficient thanothers (e.g., 1049HH cleaves faster than 1366HH).

Ribozyme Efficacy Assay in Cultured HS-27 Cells (Used in the FollowingExamples):

Ribozymes were assayed on either human foreskin fibroblasts(HS-27) cellline or primary human synovial fibroblasts (HSF). All cells were platedthe day before the assay in media containing 10% fetal bovine serum in24 well plates at a density of 5×10⁴ cells/well. At 24 hours afterplating, the media was removed from the wells and the monolayers werewashed with Dulbeccos phosphate buffered saline (PBS). The cells wereserum starved for 24 h by incubating the cells in media containing 0.5%fetal bovine serum (FBS; 1 ml/well). Ribozyme/lipid complexes wereprepared as follows: Ribozymes and LipofectAMINE were diluted separatelyin serum-free DMEM plus 20 mM Hepes pH 7.3 to 2× final concentration,then equal volumes were combined, vortexed and incubated at 37° C. for15 minutes. The charge ratio of LipofectAmine: ribozyme was 3:1. Cellswere washed twice with PBS containing Ca²⁺ and Mg²⁺. Cells were thentreated the ribozyme/lipid complexes and incubated at 37° C. for 1.5hours. FBS was then added to a final concentration of 10%. Two hoursafter FBS addition, the ribozyme containing solution was removed and 0.5ml DMEM containing 50 u/ml IL-1, 10% FBS, 20 mM Hepes pH 7.3 added.Supernatants were harvested 16 hours after IL-1 induction and assayedfor stromelysin expression by ELISA. Polyclonal antibody against MatrixMetalloproteinase 3 (Biogenesis, NH) was used as the detecting antibodyand anti-stromelysin monoclonal antibody was used as the capturingantibody in the sandwich ELISA (Maniatis et al., supra) to measurestromelysin expression.

EXAMPLE 12

Ribozyme-Mediated Inhibition of Stromelysin Expression in humanfibroblast cells

Referring to FIGS. 8 through 13, HH ribozymes, targeted to sites 21,463, 1049, 1366, 1403, 1410 and 1489 within human stromelysin-1 mRNA,were transfected into HS-27 fibroblast or HSF cell line as describedabove. Catalytically inactive ribozymes that contain 2 nucleotidechanges in the catalytic core region were also synthesized for use. ascontrols. The catalytic core in the inactive ribozymes wasCUUAUGAGGCCGAAAGGCCGAU versus CUGAUGAGGCCGAAAGGCCGAA in the activeribozymes. The inactive ribozymes show no cleavage activity in vitrowhen measured on full-length RNA in the typical ribozyme cleavage assayat a 1 μM concentration for 1 hour. Levels of stromelysin protein weremeasured using a sensitive ELISA protocol as described above. +IL-1 inthe figures mean that cells were treated with IL-1 to induce theexpression of stromelysin expression. -IL-1 means that the cells werenot treated. FIGS. 8 through 14 show the dramatic reduction in thelevels of stromelysin protein expressed in cells that were transfectedwith active HH ribozymes. This decrease in the level of stromelysinproduction is over and above some non-specific inhibition seen in cellsthat were transfected with catalytically inactive ribozymes. There is onan average a greater than 50% inhibition in stromelysin production (incells transfected with active HH ribozymes) when compared with controlcells that were transfected with inactive ribozymes. These resultssuggest that the reduction in stromelysin production in HS-27 cells ismediated by sequence-specific cleavage of human stromelysin-1 mRNA bycatalytically selective HH ribozymes. Reduction in stromelysin proteinproduction in cells transfected with catalytically inactive ribozymesmay be due to some "antisense effect" caused by binding of the inactiveribozyme to the target RNA and physically preventing translation.

EXAMPLE 13

Ribozyme-mediated inhibition of stromelysin expression in Rabbit Knee

In order to extend the ribozyme efficacy in cell culture, applicant hischosen to use rabbit knee as a reasonable animal model to studyribozyme-mediated inhibition of rabbit stromelysin protein expression.Applicant selected a HH ribozyme (1049HH), targeted to site 1049 withinhuman stromelysin-1 mRNA, for animal studies because site 1049 is 100%identical to site 1060 (Tables III and VI) within rabbit stromelysinmRNA. This has enabled applicant to compare the efficacy of the sameribozyme in human as well as in rabbit systems.

Male New Zealand White Rabbits (3-4 Kg) were anaesthetized withketamine-HCl/xylazine and injected intra-articularly (I.T.) in bothknees with 100 μg ribozyme (e.g., SEQ. ID. NO. 202) in 0.5 ml phosphatebuffered saline (PBS) or PBS alone (Controls). The IL-1 (humanrecombinant IL-1α, 25 ng) was administered I.T., 24 hours following theribozyme administration. Each rabbit received IL-1 in one knee and PBSalone in the other. The synovium was harvested 6 hours post IL-1infusion, snap frozen in liquid nitrogen, and stored at -80° C. TotalRNA is extracted with TRIzol reagent (GIBCO BRL, Gaithersburg, Md.), andwas analyzed by Northern-blot analysis and/or RNase-protection assay.Briefly, 0.5 μg cellular RNA was separated on 1.0 % agarose/formaldehydegel and transferred to Zeta-Probe GT nylon membrane (Bio-Rad, Hercules,Calif.) by capillary transfer for ˜16 hours. The blots were baked fortwo hours and then pre-hybridized for 2 hours at 65° C. in 10 ml Churchhybridization buffer (7% SDS, 500 mM phosphate, 1 mM EDTA, 1% BovineSerum Albumin). The blots were hybridized at 65° C. for ˜16 hours with10⁶ cpm/ml of full length ³² P-labeled complementary RNA (cRNA) probesto rabbit stromelysin mRNA (cRNA added to the pre-hybridization bufferalong with 100 μl 10 mg/ml salmon sperm DNA). The blot was rinsed oncewith 5% SDS, 25 mM phosphate, 1 mM EDTA and 0.5% BSA for 10 min at roomtemperature. This was followed by two washes (10 min each wash) with thesame buffer at 65° C., which was then followed by two washes (10 mineach wash) at 65° C. with 1% SDS, 25 mM phosphate and 1 mM EDTA. Theblot was autoradiographed. The blot was reprobed with a 100 nt cRNAprobe to 18S rRNA as described above. Following autoradiography, thestromelysin expression was quantified on a scanning densitometer, whichis followed by normalization of the data to the 18S rRNA bandintensities.

As shown in FIGS. 14-16, catalytically active 1049HH ribozyme mediates adecrease in the expression of stromelysin expression in rabbit knees.The inhibition appears to be sequence-specific and ranges from 50-70%.

EXAMPLE 14

Phosphorothioate-substituted Ribozymes inhibit stromelysin expression inRabbit Knee

Ribozymes containing four phosphorothioate linkages at the 5' terminienhance ribozyme efficacy in mammalian cells. Referring to FIG. 17,applicant has designed and synthesized hammerhead ribozymes targeted tosite 1049 within stromelysin RNA, wherein, the ribozymes contain fivephosphorothioate linkages at their 5' and 3' termini. Additionally,these ribozymes contain 2'-O-methyl substitutions at 30 nucleotidepositions, 2'-C-allyl substitution at U4 position and 2'-OH at fivepositions (FIG. 17A). As described above, these ribozymes wereadministered to rabbit knees to test for ribozyme efficacy. The 1049U4-C-allyl P═S active ribozyme shows greater than 50% reduction in thelevel of stromelysin RNA in rabbit knee. Catalytically inactive versionof the 1049 U4-C-allyl P═S ribozyme shows ˜30% reduction in the level ofstromelysin RNA.

Referring to FIG. 18, applicant has also designed and synthesizedhammerhead ribozymes targeted to three distinct sites within stromelysinRNA, wherein, the ribozymes contain four phosphorothioate linkages attheir 5' termini. Additionally, these ribozymes contain 2'-O-methylsubstitutions at 29 nucleotide positions, 2'-amino substitutions at U4and U7 positions and 2'-OH at five positions. As described above, theseribozymes were administered to rabbit knees to test for ribozymeefficacy. As shown in FIGS. 18, 19 and 20, ribozymes targeted to sites1049, 1363 and 1366 are all efficacious in rabbit knee. All threeribozymes decreased the level of stromelysin RNA in rabbit knee by about50%.

Sequences and chemical modifications described in FIGS. 17 and 18 aremeant to be non-limiting examples. Those skilled in the art willrecognize that similar embodiments with other ribozymes and ribozymescontaining other chemical modifications can be readily generated usingtechniques known in the art and are within the scope of the presentinvention.

Applicant has shown that chemical modifications, such as 6-methyl U andabasic (nucleotide containing no base) moieties can be substituted atcertain positions within the ribozyme, for example U4 and U7 positions,without significantly effecting the catalytic activity of the ribozyme.Similarly, 3'-3' linked abasic inverted ribose moieties can be used toprotect the 3' ends of ribozymes in place of an inverted T withouteffecting the activity of the ribozyme.

Other embodiments are within the following claims.

TABLE I Characteristics of Ribozymes

Group I Introns

Size: ˜200 to >1000 nucleotides.

Requires a U in the target sequence immediately 5' of the cleavage site.

Binds 4-6 nucleotides at 5' side of cleavage site.

Over 75 known members of this class. Found in Tetrahymena thermophilarRNA, fungal mitochondria, chloroplasts, phage T4, blue-green algae, andothers.

RNAseP RNA (M1 RNA)

Size: ˜290 to 400 nucleotides.

RNA portion of a ribonucleoprotein enzyme. Cleaves tRNA precursors toform mature tRNA.

Roughly 10 known members of this group all are bacterial in origin.

Hammerhead Ribozyme

Size: ˜13 to 40 nucleotides.

Requires the target sequence UH immediately 5' of the cleavage site.

Binds a variable number nucleotides on both sides of the cleavage site.

14 known members of this class. Found in a number of plant pathogens(virusoids) that use RNA as the infectious agent (FIG. 1)

Hairpin Ribozyme

Size: ˜50 nucleotides.

Requires the target sequence GUC immediately 3' of the cleavage site.

Binds 4-6 nucleotides at 5' side of the cleavage site and a variablenumber to the 3' side of the cleavage site.

Only 3 known member of this class. Found in three plant pathogen(satellite RNAs of the tobacco ringspot virus, arabis mosaic virus andchicory yellow mottle virus) which uses RNA as the infectious agent(FIG. 3).

Hepatitis Delta Virus (HDV) Ribozyme

Size: 50-60 nucleotides (at present).

Cleavage of target RNAs recently demonstrated.

Sequence requirements not fully determined.

Binding sites and structural requirements not fully determined, althoughno sequences 5' of cleavage site are required.

Only 1 known member of this class. Found in human HDV (FIG. 4).

Neurospora VS RNA Ribozyme

Size: ˜144 nucleotides (at present)

Cleavage of target RNAs recently demonstrated.

Sequence requirements not fully determined.

Binding sites and structural requirements not fully determined. Only 1known member of this class. Found in Neurospora VS RNA (FIG. 5).

                  TABLE II                                                        ______________________________________                                        Hammerhead Target Sequence                                                    nt                                                                            Posi-                            SEQ.                                         tion Sequence                    ID. NO.                                      ______________________________________                                         20  UAGAGCUAAGUAAAGCCAG         ID. NO.                                                                       01                                            126 ACACCAGCAUGAA               ID. NO.                                                                       02                                            147 AGAAAUAUCUAGA               ID. NO.                                                                       03                                            171 ACCUCAAAAAAGAUGUGAAACAGU    ID. NO.                                                                       04                                            240 AAAUGCAGAAGUUC              ID. NO.                                                                       05                                            287 GACACUCUGGAGGUGAUGCGCAAGCCCAGGUGU                                                                         ID. NO.                                                                       06                                            327 CUGAUGUUGGUCACUUCAGAAC      ID. NO.                                                                       07                                            357 GCAUCCCGAAGUGGAGGAAAACCCACCUUACAU                                                                         ID. NO.                                                                       08                                            402 AUUAUACACCAGAUUUGCCAAAAGAUG ID. NO.                                                                       09                                            429 CUGUUGAUUCUGCUGUUGAGA       ID. NO.                                                                       10                                            455 CUGAAAGUCUGGGAAGAGGUGA      ID. NO.                                                                       11                                            513 CUGAUAUAAUGA                ID. NO.                                                                       12                                            592 UGCCUAUGCCCC                ID. NO.                                                                       13                                            624 AUGCCCACUUUGAUGAUGAUGAACAAUGGACA                                                                          ID. NO.                                                                       14                                            679 AUUUCUCGUUGCUGCUCAUG        ID. NO.                                                                       15                                            725 CACUCAGCCAACACUGA           ID. NO.                                                                       16                                            801 AAGAUGAUAUAAAUGGCAUUCAGUCC  ID. NO.                                                                       17                                            827 CUCUAUGGACCUCCCCCUGACUCCCCU ID. NO.                                                                       18                                            859 CCCCCUGGUACCCA              ID. NO.                                                                       19                                            916 UCCUGCUUUGUCCUUUGAUGCUGUCAGCAC                                                                            ID. NO.                                                                       20                                            958 AAUCCUGAUCUUUAAAGA          ID. NO.                                                                       21                                            975 CAGGCACUUUUGGCGCAAAUCCC     ID. NO.                                                                       22                                           1018 AUUGCAUUUGAUCUCUUCAUUUUGGCCAUC                                                                            ID. NO.                                                                       23                                           1070 GCAUAUGAAGUUA               ID. NO.                                                                       24                                           1203 AAAUCGAUGCAGCCAUUUCUGA      ID. NO.                                                                       25                                           1274 UUUGAUGAGAAGAGAAAUUCCAUGGAGC                                                                              ID. NO.                                                                       26                                           1302 CAGGCUUUCCCAAGCAAAUAGCUGAAGAC                                                                             ID. NO.                                                                       27                                           1420 CCCAAAUGCAAAG               ID. NO.                                                                       28                                           1485 AUGUAGAAGGCACAAUAUGGGCACUUUAAA                                                                            ID. NO.                                                                       29                                           1623 UCUUGCCGGUCAUUUUUAUGUUAU    ID. NO.                                                                       30                                           1665 GCUGCUGCUUAGC               ID. NO.                                                                       31                                           1733 CAACAGACAAGUGACUGUAUCU      ID. NO.                                                                       32                                           1769 CUUAUUUAAUA                 ID. NO.                                                                       33                                           ______________________________________                                    

                                      TABLE III                                   __________________________________________________________________________    Human Stromelysin HH Target Sequence                                          nt.                                                                           Position                                                                           Target Sequence            Seq. ID. NO.                                  __________________________________________________________________________    10   GCAAGGCAUA GAGACAACAUAGAGC ID. NO. 34                                    21   GCAUAGAGACAACAUA GAGCUAAGUAAAGCC                                                                         ID. NO. 35                                    27   AGACAACAUAGAGCUA AGUAAAGCCAGUGGA                                                                         ID. NO. 36                                    31   AACAUAGAGCUAAGUA AAGCCAGUGGAAAUG                                                                         ID. NO. 37                                    53   GUGGAAAUGAAGAGUCUUCCAAUCCUACUGU                                                                          ID. NO. 38                                    55   GGAAAUGAAGAGUCUU CCAAUCCUACUGUUG                                                                         ID. NO. 39                                    56   GAAAUGAAGAGUCUUCCAAUCCUACUGUUGC                                                                          ID. NO. 40                                    61   GAAGAGUCUUCCAAUCCUACUGUUGCUGUGC                                                                          ID. NO. 41                                    64   GAGUCUUCCAAUCCUA CUGUUGCUGUGCGUG                                                                         ID. NO. 42                                    69   UUCCAAUCCUACUGUU GCUGUGCGUGGCAGU                                                                         ID. NO. 43                                    85   GCUGUGCGUGGCAGUU UGCUCAGCCUAUCCA                                                                         ID. NO. 44                                    86   CUGUGCGUGGCAGUUU GCUCAGCCUAUCCAU                                                                         ID. NO. 45                                    90   GCGUGGCAGUUUGCUCAGCCUAUCCAUUGGA                                                                          ID. NO. 46                                    96   CAGUUUGCUCAGCCUA UCCAUUGGAUGGAGC                                                                         ID. NO. 47                                    98   GUUUGCUCAGCCUAUCCAUUGGAUGGAGCUG                                                                          ID. NO. 48                                    102  GCUCAGCCUAUCCAUU GGAUGGAGCUGCAAG                                                                         ID. NO. 49                                    142  CACCAGCAUGAACCUU GUUCAGAAAUAUCUA                                                                         ID. NO. 50                                    145  CAGCAUGAACCUUGUU CAGAAAUAUCUAGAA                                                                         ID. NO. 51                                    146  AGCAUGAACCUUGUUCAGAAAUAUCUAGAAA                                                                          ID. NO. 52                                    153  ACCUUGUUCAGAAAUA UCUAGAAAACUACUA                                                                         ID. NO. 53                                    155  CUUGUUCAGAAAUAUCUAGAAAACUACUACG                                                                          ID. NO. 54                                    157  UGUUCAGAAAUAUCUA GAAAACUACUACGAC                                                                         ID. NO. 55                                    165  AAUAUCUAGAAAACUA CUACGACCUCAAAAA                                                                         ID. NO. 56                                    168  AUCUAGAAAACUACUA CGACCUCAAAAAAGA                                                                         ID. NO. 57                                    175  AAACUACUACGACCUCAAAAAAGAUGUGAAA                                                                          ID. NO. 58                                    195  AAGAUGUGAAACAGUU UGUUAGGAGAAAGGA                                                                         ID. NO. 59                                    196  AGAUGUGAAACAGUUU GUUAGGAGAAAGGAC                                                                         ID. NO. 60                                    199  UGUGAAACAGUUUGUU AGGAGAAAGGACAGU                                                                         ID. NO. 61                                    200  GUGAAACAGUUUGUUA GGAGAAAGGACAGUG                                                                         ID. NO. 62                                    218  AGAAAGGACAGUGGUCCUGUUGUUAAAAAAA                                                                          ID. NO. 63                                    223  GGACAGUGGUCCUGUU GUUAAAAAAAUCCGA                                                                         ID. NO. 64                                    226  CAGUGGUCCUGUUGUU AAAAAAAUCCGAGAA                                                                         ID. NO. 65                                    227  AGUGGUCCUGUUGUUA AAAAAAUCCGAGAAA                                                                         ID. NO. 66                                    235  UGUUGUUAAAAAAAUCCGAGAAAUGCAGAAG                                                                          ID. NO. 67                                    252  GAGAAAUGCAGAAGUU CCUUGGAUUGGAGGU                                                                         ID. NO. 68                                    253  AGAAAUGCAGAAGUUCCUUGGAUUGGAGGUG                                                                          ID. NO. 69                                    256  AAUGCAGAAGUUCCUU GGAUUGGAGGUGACG                                                                         ID. NO. 70                                    261  AGAAGUUCCUUGGAUU GGAGGUGACGGGGAA                                                                         ID. NO. 71                                    285  CGGGGAAGCUGGACUCCGACACUCUGGAGGU                                                                          ID. NO. 72                                    293  CUGGACUCCGACACUCUGGAGGUGAUGCGCA                                                                          ID. NO. 73                                    325  GCCCAGGUGUGGAGUU CCUGAUGUUGGUCAC                                                                         ID. NO. 74                                    326  CCCAGGUGUGGAGUUCCUGAUGUUGGUCACU                                                                          ID. NO. 75                                    334  UGGAGUUCCUGAUGUU GGUCACUUCAGAACC                                                                         ID. NO. 76                                    338  GUUCCUGAUGUUGGUCACUUCAGAACCUUUC                                                                          ID. NO. 77                                    342  CUGAUGUUGGUCACUU CAGAACCUUUCCUGG                                                                         ID. NO. 78                                    343  UGAUGUUGGUCACUUCAGAACCUUUCCUGGC                                                                          ID. NO. 79                                    351  GUCACUUCAGAACCUU UCCUGGCAUCCCGAA                                                                         ID. NO. 80                                    352  UCACUUCAGAACCUUU CCUGGCAUCCCGAAG                                                                         ID. NO. 81                                    353  CACUUCAGAACCUUUCCUGGCAUCCCGAAGU                                                                          ID. NO. 82                                    361  AACCUUUCCUGGCAUCCCGAAGUGGAGGAAA                                                                          ID. NO. 83                                    385  GAGGAAAACCCACCUU ACAUACAGGAUUGUG                                                                         ID. NO. 84                                    386  AGGAAAACCCACCUUA CAUACAGGAUUGUGA                                                                         ID. NO. 85                                    390  AAACCCACCUUACAUA CAGGAUUGUGAAUUA                                                                         ID. NO. 86                                    397  CCUUACAUACAGGAUU GUGAAUUAUACACCA                                                                         ID. NO. 87                                    404  UACAGGAUUGUGAAUU AUACACCAGAUUUGC                                                                         ID. NO. 88                                    405  ACAGGAUUGUGAAUUA UACACCAGAUUUGCC                                                                         ID. NO. 89                                    407  AGGAUUGUGAAUUAUA CACCAGAUUUGCCAA                                                                         ID. NO. 90                                    416  AAUUAUACACCAGAUU UGCCAAAAGAUGCUG                                                                         ID. NO. 91                                    417  AUUAUACACCAGAUUU GCCAAAAGAUGCUGU                                                                         ID. NO. 92                                    433  GCCAAAAGAUGCUGUU GAUUCUGCUGUUGAG                                                                         ID. NO. 93                                    437  AAAGAUGCUGUUGAUU CUGCUGUUGAGAAAG                                                                         ID. NO. 94                                    438  AAGAUGCUGUUGAUUCUGCUGUUGAGAAAGC                                                                          ID. NO. 95                                    445  UGUUGAUUCUGCUGUU GAGAAAGCUCUGAAA                                                                         ID. NO. 96                                    455  GCUGUUGAGAAAGCUCUGAAAGUCUGGGAAG                                                                          ID. NO. 97                                    463  GAAAGCUCUGAAAGUCUGGGAAGAGGUGACU                                                                          ID. NO. 98                                    479  UGGGAAGAGGUGACUCCACUCACAUUCUCCA                                                                          ID. NO. 99                                    484  AGAGGUGACUCCACUCACAUUCUCCAGGCUG                                                                          ID. NO. 100                                   489  UGACUCCACUCACAUU CUCCAGGCUGUAUGA                                                                         ID. NO. 101                                   490  GACUCCACUCACAUUCUCCAGGCUGUAUGAA                                                                          ID. NO. 102                                   492  CUCCACUCACAUUCUCCAGGCUGUAUGAAGG                                                                          ID. NO. 103                                   501  CAUUCUCCAGGCUGUA UGAAGGAGAGGCUGA                                                                         ID. NO. 104                                   518  GAAGGAGAGGCUGAUA UAAUGAUCUCUUUUG                                                                         ID. NO. 105                                   520  AGGAGAGGCUGAUAUA AUGAUCUCUUUUGCA                                                                         ID. NO. 106                                   526  GGCUGAUAUAAUGAUCUCUUUUGCAGUUAGA                                                                          ID. NO. 107                                   528  CUGAUAUAAUGAUCUCUUUUGCAGUUAGAGA                                                                          ID. NO. 108                                   530  GAUAUAAUGAUCUCUU UUGCAGUUAGAGAAC                                                                         ID. NO. 109                                   531  AUAUAAUGAUCUCUUU UGCAGUUAGAGAACA                                                                         ID. NO. 110                                   532  UAUAAUGAUCUCUUUU GCAGUUAGAGAACAU                                                                         ID. NO. 111                                   538  GAUCUCUUUUGCAGUU AGAGAACAUGGAGAC                                                                         ID. NO. 112                                   539  AUCUCUUUUGCAGUUA GAGAACAUGGAGACU                                                                         ID. NO. 113                                   555  GAGAACAUGGAGACUU UUACCCUUUUGAUGG                                                                         ID. NO. 114                                   556  AGAACAUGGAGACUUU UACCCUUUUGAUGGA                                                                         ID. NO. 115                                   557  GAACAUGGAGACUUUU ACCCUUUUGAUGGAC                                                                         ID. NO. 116                                   558  AACAUGGAGACUUUUA CCCUUUUGAUGGACC                                                                         ID. NO. 117                                   563  GGAGACUUUUACCCUU UUGAUGGACCUGGAA                                                                         ID. NO. 118                                   564  GAGACUUUUACCCUUU UGAUGGACCUGGAAA                                                                         ID. NO. 119                                   565  AGACUUUUACCCUUUU GAUGGACCUGGAAAU                                                                         ID. NO. 120                                   583  UGGACCUGGAAAUGUU UUGGCCCAUGCCUAU                                                                         ID. NO. 121                                   584  GGACCUGGAAAUGUUU UGGCCCAUGCCUAUG                                                                         ID. NO. 122                                   585  GACCUGGAAAUGUUUU GGCCCAUGCCUAUGC                                                                         ID. NO. 123                                   597  UUUUGGCCCAUGCCUA UGCCCCUGGGCCAGG                                                                         ID. NO. 124                                   616  CCCUGGGCCAGGGAUU AAUGGAGAUGCCCAC                                                                         ID. NO. 125                                   617  CCUGGGCCAGGGAUUA AUGGAGAUGCCCACU                                                                         ID. NO. 126                                   633  AUGGAGAUGCCCACUU UGAUGAUGAUGAACA                                                                         ID. NO. 127                                   634  UGGAGAUGCCCACUUU GAUGAUGAUGAACAA                                                                         ID. NO. 128                                   662  CAAUGGACAAAGGAUA CAACAGGGACCAAUU                                                                         ID. NO. 129                                   677  ACAACAGGGACCAAUU UAUUUCUCGUUGCUG                                                                         ID. NO. 130                                   678  CAACAGGGACCAAUUU AUUUCUCGUUGCUGC                                                                         ID. NO. 131                                   679  AACAGGGACCAAUUUA UUUCUCGUUGCUGCU                                                                         ID. NO. 132                                   681  CAGGGACCAAUUUAUU UCUCGUUGCUGCUCA                                                                         ID. NO. 133                                   682  AGGGACCAAUUUAUUU CUCGUUGCUGCUCAU                                                                         ID. NO. 134                                   683  GGGACCAAUUUAUUUCUCGUUGCUGCUCAUG                                                                          ID. NO. 135                                   685  GACCAAUUUAUUUCUCGUUGCUGCUCAUGAA                                                                          ID. NO. 136                                   688  CAAUUUAUUUCUCGUU GCUGCUCAUGAAAUU                                                                         ID. NO. 137                                   695  UUUCUCGUUGCUGCUCAUGAAAUUGGCCACU                                                                          ID. NO. 138                                   703  UGCUGCUCAUGAAAUU GGCCACUCCCUGGGU                                                                         ID. NO. 139                                   711  AUGAAAUUGGCCACUCCCUGGGUCUCUUUCA                                                                          ID. NO. 140                                   719  GGCCACUCCCUGGGUCUCUUUCACUCAGCCA                                                                          ID. NO. 141                                   721  CCACUCCCUGGGUCUCUUUCACUCAGCCAAC                                                                          ID. NO. 142                                   723  ACUCCCUGGGUCUCUU UCACUCAGCCAACAC                                                                         ID. NO. 143                                   724  CUCCCUGGGUCUCUUU CACUCAGCCAACACU                                                                         ID. NO. 144                                   725  UCCCUGGGUCUCUUUCACUCAGCCAACACUG                                                                          ID. NO. 145                                   729  UGGGUCUCUUUCACUCAGCCAACACUGAAGC                                                                          ID. NO. 146                                   746  GCCAACACUGAAGCUU UGAUGUACCCACUCU                                                                         ID. NO. 147                                   747  CCAACACUGAAGCUUU GAUGUACCCACUCUA                                                                         ID. NO. 148                                   753  CUGAAGCUUUGAUGUA CCCACUCUAUCACUC                                                                         ID. NO. 149                                   760  UUUGAUGUACCCACUCUAUCACUCACUCACA                                                                          ID. NO. 150                                   762  UGAUGUACCCACUCUA UCACUCACUCACAGA                                                                         ID. NO. 151                                   764  AUGUACCCACUCUAUCACUCACUCACAGACC                                                                          ID. NO. 152                                   768  ACCCACUCUAUCACUCACUCACAGACCUGAC                                                                          ID. NO. 153                                   772  ACUCUAUCACUCACUCACAGACCUGACUCGG                                                                          ID. NO. 154                                   785  CUCACAGACCUGACUCGGUUCCGCCUGUCUC                                                                          ID. NO. 155                                   789  CAGACCUGACUCGGUU CCGCCUGUCUCAAGA                                                                         ID. NO. 156                                   790  AGACCUGACUCGGUUCCGCCUGUCUCAAGAU                                                                          ID. NO. 157                                   798  CUCGGUUCCGCCUGUCUCAAGAUGAUAUAAA                                                                          ID. NO. 158                                   800  CGGUUCCGCCUGUCUCAAGAUGAUAUAAAUG                                                                          ID. NO. 159                                   809  CUGUCUCAAGAUGAUA UAAAUGGCAUUCAGU                                                                         ID. NO. 160                                   811  GUCUCAAGAUGAUAUA AAUGGCAUUCAGUCC                                                                         ID. NO. 161                                   820  UGAUAUAAAUGGCAUU CAGUCCCUCUAUGGA                                                                         ID. NO. 162                                   821  GAUAUAAAUGGCAUUCAGUCCCUCUAUGGAC                                                                          ID. NO. 163                                   825  UAAAUGGCAUUCAGUCCCUCUAUGGACCUCC                                                                          ID. NO. 164                                   829  UGGCAUUCAGUCCCUCUAUGGACCUCCCCCU                                                                          ID. NO. 165                                   831  GCAUUCAGUCCCUCUA UGGACCUCCCCCUGA                                                                         ID. NO. 166                                   839  UCCCUCUAUGGACCUCCCCCUGACUCCCCUG                                                                          ID. NO. 167                                   849  GACCUCCCCCUGACUCCCCUGAGACCCCCCU                                                                          ID. NO. 168                                   868  UGAGACCCCCCUGGUA CCCACGGAACCUGUC                                                                         ID. NO. 169                                   883  ACCCACGGAACCUGUCCCUCCAGAACCUGGG                                                                          ID. NO. 170                                   887  ACGGAACCUGUCCCUCCAGAACCUGGGACGC                                                                          ID. NO. 171                                   917  CCAGCCAACUGUGAUCCUGCUUUGUCCUUUG                                                                          ID. NO. 172                                   923  AACUGUGAUCCUGCUU UGUCCUUUGAUGCUG                                                                         ID. NO. 173                                   924  ACUGUGAUCCUGCUUU GUCCUUUGAUGCUGU                                                                         ID. NO. 174                                   927  GUGAUCCUGCUUUGUCCUUUGAUGCUGUCAG                                                                          ID. NO. 175                                   930  AUCCUGCUUUGUCCUU UGAUGCUGUCAGCAC                                                                         ID. NO. 176                                   931  UCCUGCUUUGUCCUUU GAUGCUGUCAGCACU                                                                         ID. NO. 177                                   940  GUCCUUUGAUGCUGUCAGCACUCUGAGGGGA                                                                          ID. NO. 178                                   947  GAUGCUGUCAGCACUCUGAGGGGAGAAAUCC                                                                          ID. NO. 179                                   961  UCUGAGGGGAGAAAUCCUGAUCUUUAAAGAC                                                                          ID. NO. 180                                   967  GGGAGAAAUCCUGAUCUUUAAAGACAGGCAC                                                                          ID. NO. 181                                   969  GAGAAAUCCUGAUCUU UAAAGACAGGCACUU                                                                         ID. NO. 182                                   970  AGAAAUCCUGAUCUUU AAAGACAGGCACUUU                                                                         ID. NO. 183                                   971  GAAAUCCUGAUCUUUA AAGACAGGCACUUUU                                                                         ID. NO. 184                                   984  UUAAAGACAGGCACUU UUGGCGCAAAUCCCU                                                                         ID. NO. 185                                   985  UAAAGACAGGCACUUU UGGCGCAAAUCCCUC                                                                         ID. NO. 186                                   986  AAAGACAGGCACUUUU GGCGCAAAUCCCUCA                                                                         ID. NO. 187                                   996  ACUUUUGGCGCAAAUCCCUCAGGAAGCUUGA                                                                          ID. NO. 188                                   1000 UUGGCGCAAAUCCCUCAGGAAGCUUGAACCU                                                                          ID. NO. 189                                   1009 AUCCCUCAGGAAGCUU GAACCUGAAUUGCAU                                                                         ID. NO. 190                                   1020 AGCUUGAACCUGAAUU GCAUUUGAUCUCUUC                                                                         ID. NO. 191                                   1025 GAACCUGAAUUGCAUU UGAUCUCUUCAUUUU                                                                         ID. NO. 192                                   1026 AACCUGAAUUGCAUUU GAUCUCUUCAUUUUG                                                                         ID. NO. 193                                   1030 UGAAUUGCAUUUGAUCUCUUCAUUUUGGCCA                                                                          ID. NO. 194                                   1032 AAUUGCAUUUGAUCUCUUCAUUUUGGCCAUC                                                                          ID. NO. 195                                   1034 UUGCAUUUGAUCUCUU CAUUUUGGCCAUCUC                                                                         ID. NO. 196                                   1035 UGCAUUUGAUCUCUUCAUUUUGGCCAUCUCU                                                                          ID. NO. 197                                   1038 AUUUGAUCUCUUCAUU UUGGCCAUCUCUUCC                                                                         ID. NO. 198                                   1039 UUUGAUCUCUUCAUUU UGGCCAUCUCUUCCU                                                                         ID. NO. 199                                   1040 UUGAUCUCUUCAUUUU GGCCAUCUCUUCCUU                                                                         ID. NO. 200                                   1047 CUUCAUUUUGGCCAUCUCUUCCUUCAGGCGU                                                                          ID. NO. 201                                   1049 UCAUUUUGGCCAUCUCUUCCUUCAGGCGUGG                                                                          ID. NO. 202                                   1051 AUUUUGGCCAUCUCUU CCUUCAGGCGUGGAU                                                                         ID. NO. 203                                   1052 UUUUGGCCAUCUCUUCCUUCAGGCGUGGAUG                                                                          ID. NO. 204                                   1055 UGGCCAUCUCUUCCUU CAGGCGUGGAUGCCG                                                                         ID. NO. 205                                   1056 GGCCAUCUCUUCCUUCAGGCGUGGAUGCCGC                                                                          ID. NO. 206                                   1074 GCGUGGAUGCCGCAUA UGAAGUUACUAGCAA                                                                         ID. NO. 207                                   1081 UGCCGCAUAUGAAGUU ACUAGCAAGGACCUC                                                                         ID. NO. 208                                   1082 GCCGCAUAUGAAGUUA CUAGCAAGGACCUCG                                                                         ID. NO. 209                                   1085 GCAUAUGAAGUUACUA GCAAGGACCUCGUUU                                                                         ID. NO. 210                                   1096 UACUAGCAAGGACCUCGUUUUCAUUUUUAAA                                                                          ID. NO. 211                                   1099 UAGCAAGGACCUCGUU UUCAUUUUUAAAGGA                                                                         ID. NO. 212                                   1100 AGCAAGGACCUCGUUU UCAUUUUUAAAGGAA                                                                         ID. NO. 213                                   1101 GCAAGGACCUCGUUUU CAUUUUUAAAGGAAA                                                                         ID. NO. 214                                   1102 CAAGGACCUCGUUUUCAUUUUUAAAGGAAAU                                                                          ID. NO. 215                                   1105 GGACCUCGUUUUCAUU UUUAAAGGAAAUCAA                                                                         ID. NO. 216                                   1106 GACCUCGUUUUCAUUU UUAAAGGAAAUCAAU                                                                         ID. NO. 217                                   1107 ACCUCGUUUUCAUUUU UAAAGGAAAUCAAUU                                                                         ID. NO. 218                                   1108 CCUCGUUUUCAUUUUU AAAGGAAAUCAAUUC                                                                         ID. NO. 219                                   1109 CUCGUUUUCAUUUUUA AAGGAAAUCAAUUCU                                                                         ID. NO. 220                                   1118 AUUUUUAAAGGAAAUCAAUUCUGGGCCAUCA                                                                          ID. NO. 221                                   1122 UUAAAGGAAAUCAAUU CUGGGCCAUCAGAGG                                                                         ID. NO. 222                                   1123 UAAAGGAAAUCAAUUCUGGGCCAUCAGAGGA                                                                          ID. NO. 223                                   1132 UCAAUUCUGGGCCAUCAGAGGAAAUGAGGUA                                                                          ID. NO. 224                                   1147 CAGAGGAAAUGAGGUA CGAGCUGGAUACCCA                                                                         ID. NO. 225                                   1158 AGGUACGAGCUGGAUA CCCAAGAGGCAUCCA                                                                         ID. NO. 226                                   1171 AUACCCAAGAGGCAUCCACACCCUAGGUUUC                                                                          ID. NO. 227                                   1180 AGGCAUCCACACCCUA GGUUUCCCUCCAACC                                                                         ID. NO. 228                                   1184 AUCCACACCCUAGGUU UCCCUCCAACCGUGA                                                                         ID. NO. 229                                   1185 UCCACACCCUAGGUUU CCCUCCAACCGUGAG                                                                         ID. NO. 230                                   1186 CCACACCCUAGGUUUCCCUCCAACCGUGAGG                                                                          ID. NO. 231                                   1190 ACCCUAGGUUUCCCUCCAACCGUGAGGAAAA                                                                          ID. NO. 232                                   1207 AACCGUGAGGAAAAUCGAUGCAGCCAUUUCU                                                                          ID. NO. 233                                   1219 AAUCGAUGCAGCCAUU UCUGAUAAGGAAAAG                                                                         ID. NO. 234                                   1220 AUCGAUGCAGCCAUUU CUGAUAAGGAAAAGA                                                                         ID. NO. 235                                   1221 UCGAUGCAGCCAUUUCUGAUAAGGAAAAGAA                                                                          ID. NO. 236                                   1226 GCAGCCAUUUCUGAUA AGGAAAAGAACAAAA                                                                         ID. NO. 237                                   1245 AAAAGAACAAAACAUA UUUCUUUGUAGAGGA                                                                         ID. NO. 238                                   1247 AAGAACAAAACAUAUU UCUUUGUAGAGGACA                                                                         ID. NO. 239                                   1248 AGAACAAAACAUAUUU CUUUGUAGAGGACAA                                                                         ID. NO. 240                                   1249 GAACAAAACAUAUUUCUUUGUAGAGGACAAA                                                                          ID. NO. 241                                   1251 ACAAAACAUAUUUCUU UGUAGAGGACAAAUA                                                                         ID. NO. 242                                   1252 CAAAACAUAUUUCUUU GUAGAGGACAAAUAC                                                                         ID. NO. 243                                   1255 AACAUAUUUCUUUGUA GAGGACAAAUACUGG                                                                         ID. NO. 244                                   1266 UUGUAGAGGACAAAUA CUGGAGAUUUGAUGA                                                                         ID. NO. 245                                   1275 ACAAAUACUGGAGAUU UGAUGAGAAGAGAAA                                                                         ID. NO. 246                                   1276 CAAAUACUGGAGAUUU GAUGAGAAGAGAAAU                                                                         ID. NO. 247                                   1292 GAUGAGAAGAGAAAUU CCAUGGAGCCAGGCU                                                                         ID. NO. 248                                   1293 AUGAGAAGAGAAAUUCCAUGGAGCCAGGCUU                                                                          ID. NO. 249                                   1308 CCAUGGAGCCAGGCUU UCCCAAGCAAAUAGC                                                                         ID. NO. 250                                   1309 CAUGGAGCCAGGCUUU CCCAAGCAAAUAGCU                                                                         ID. NO. 251                                   1310 AUGGAGCCAGGCUUUCCCAAGCAAAUAGCUG                                                                          ID. NO. 252                                   1321 CUUUCCCAAGCAAAUA GCUGAAGACUUUCCA                                                                         ID. NO. 253                                   1332 AAAUAGCUGAAGACUU UCCAGGGAUUGACUC                                                                         ID. NO. 254                                   1333 AAUAGCUGAAGACUUU CCAGGGAUUGACUCA                                                                         ID. NO. 255                                   1334 AUAGCUGAAGACUUUCCAGGGAUUGACUCAA                                                                          ID. NO. 256                                   1342 AGACUUUCCAGGGAUU GACUCAAAGAUUGAU                                                                         ID. NO. 257                                   1347 UUCCAGGGAUUGACUCAAAGAUUGAUGCUGU                                                                          ID. NO. 258                                   1354 GAUUGACUCAAAGAUU GAUGCUGUUUUUGAA                                                                         ID. NO. 259                                   1363 AAAGAUUGAUGCUGUU UUUGAAGAAUUUGGG                                                                         ID. NO. 260                                   1364 AAGAUUGAUGCUGUUU UUGAAGAAUUUGGGU                                                                         ID. NO. 261                                   1365 AGAUUGAUGCUGUUUU UGAAGAAUUUGGGUU                                                                         ID. NO. 262                                   1366 GAUUGAUGCUGUUUUU GAAGAAUUUGGGUUC                                                                         ID. NO. 263                                   1374 CUGUUUUUGAAGAAUU UGGGUUCUUUUAUUU                                                                         ID. NO. 264                                   1375 UGUUUUUGAAGAAUUU GGGUUCUUUUAUUUC                                                                         ID. NO. 265                                   1380 UUGAAGAAUUUGGGUU CUUUUAUUUCUUUAC                                                                         ID. NO. 266                                   1381 UGAAGAAUUUGGGUUCUUUUAUUUCUUUACU                                                                          ID. NO. 267                                   1383 AAGAAUUUGGGUUCUU UUAUUUCUUUACUGG                                                                         ID. NO. 268                                   1384 AGAAUUUGGGUUCUUU UAUUUCUUUACUGGA                                                                         ID. NO. 269                                   1385 GAAUUUGGGUUCUUUU AUUUCUUUACUGGAU                                                                         ID. NO. 270                                   1386 AAUUUGGGUUCUUUUA UUUCUUUACUGGAUC                                                                         ID. NO. 271                                   1388 UUUGGGUUCUUUUAUU UCUUUACUGGAUCUU                                                                         ID. NO. 272                                   1389 UUGGGUUCUUUUAUUU CUUUACUGGAUCUUC                                                                         ID. NO. 273                                   1390 UGGGUUCUUUUAUUUCUUUACUGGAUCUUCA                                                                          ID. NO. 274                                   1392 GGUUCUUUUAUUUCUU UACUGGAUCUUCACA                                                                         ID. NO. 275                                   1393 GUUCUUUUAUUUCUUU ACUGGAUCUUCACAG                                                                         ID. NO. 276                                   1394 UUCUUUUAUUUCUUUA CUGGAUCUUCACAGU                                                                         ID. NO. 277                                   1401 AUUUCUUUACUGGAUCUUCACAGUUGGAGUU                                                                          ID. NO. 278                                   1403 UUCUUUACUGGAUCUU CACAGUUGGAGUUUG                                                                         ID. NO. 279                                   1404 UCUUUACUGGAUCUUCACAGUUGGAGUUUGA                                                                          ID. NO. 280                                   1410 CUGGAUCUUCACAGUU GGAGUUUGACCCAAA                                                                         ID. NO. 281                                   1416 CUUCACAGUUGGAGUU UGACCCAAAUGCAAA                                                                         ID. NO. 282                                   1417 UUCACAGUUGGAGUUU GACCCAAAUGCAAAG                                                                         ID. NO. 283                                   1448 AAAGUGACACACACUU UGAAGAGUAACAGCU                                                                         ID. NO. 284                                   1449 AAGUGACACACACUUU GAAGAGUAACAGCUG                                                                         ID. NO. 285                                   1457 CACACUUUGAAGAGUA ACAGCUGGCUUAAUU                                                                         ID. NO. 286                                   1468 GAGUAACAGCUGGCUU AAUUGUUGAAAGAGA                                                                         ID. NO. 287                                   1469 AGUAACAGCUGGCUUA AUUGUUGAAAGAGAU                                                                         ID. NO. 288                                   1472 AACAGCUGGCUUAAUU GUUGAAAGAGAUAUG                                                                         ID. NO. 289                                   1475 AGCUGGCUUAAUUGUU GAAAGAGAUAUGUAG                                                                         ID. NO. 290                                   1485 AUUGUUGAAAGAGAUA UGUAGAAGGCACAAU                                                                         ID. NO. 291                                   1489 UUGAAAGAGAUAUGUA GAAGGCACAAUAUGG                                                                         ID. NO. 292                                   1501 UGUAGAAGGCACAAUA UGGGCACUUUAAAUG                                                                         ID. NO. 293                                   1510 CACAAUAUGGGCACUU UAAAUGAAGCUAAUA                                                                         ID. NO. 294                                   1511 ACAAUAUGGGCACUUU AAAUGAAGCUAAUAA                                                                         ID. NO. 295                                   1512 CAAUAUGGGCACUUUA AAUGAAGCUAAUAAU                                                                         ID. NO. 296                                   1522 ACUUUAAAUGAAGCUA AUAAUUCUUCACCUA                                                                         ID. NO. 297                                   1525 UUAAAUGAAGCUAAUA AUUCUUCACCUAAGU                                                                         ID. NO. 298                                   1528 AAUGAAGCUAAUAAUU CUUCACCUAAGUCUC                                                                         ID. NO. 299                                   1529 AUGAAGCUAAUAAUUCUUCACCUAAGUCUCU                                                                          ID. NO. 300                                   1531 GAAGCUAAUAAUUCUU CACCUAAGUCUCUGU                                                                         ID. NO. 301                                   1532 AAGCUAAUAAUUCUUCACCUAAGUCUCUGUG                                                                          ID. NO. 302                                   1537 AAUAAUUCUUCACCUA AGUCUCUGUGAAUUG                                                                         ID. NO. 303                                   1541 AUUCUUCACCUAAGUCUCUGUGAAUUGAAAU                                                                          ID. NO. 304                                   1543 UCUUCACCUAAGUCUCUGUGAAUUGAAAUGU                                                                          ID. NO. 305                                   1551 UAAGUCUCUGUGAAUU GAAAUGUUCGUUUUC                                                                         ID. NO. 306                                   1559 UGUGAAUUGAAAUGUU CGUUUUCUCCUGCCU                                                                         ID. NO. 307                                   1560 GUGAAUUGAAAUGUUCGUUUUCUCCUGCCUG                                                                          ID. NO. 308                                   1563 AAUUGAAAUGUUCGUU UUCUCCUGCCUGUGC                                                                         ID. NO. 309                                   1564 AUUGAAUGGUUCGUUU UCUCCUGCCUGUGCU                                                                         ID. NO. 310                                   1565 UUGAAAUGUUCGUUUU CUCCUGCCUGUGCUG                                                                         ID. NO. 311                                   1566 UGAAAUGUUCGUUUUCUCCUGCCUGUGCUGU                                                                          ID. NO. 312                                   1568 AAAUGUUCGUUUUCUCCUGCCUGUGCUGUGA                                                                          ID. NO. 313                                   1586 GCCUGUGCUGUGACUCGAGUCACACUCAAGG                                                                          ID. NO. 314                                   1591 UGCUGUGACUCGAGUCACACUCAAGGGAACU                                                                          ID. NO. 315                                   1597 GACUCGAGUCACACUCAAGGGAACUUGAGCG                                                                          ID. NO. 316                                   1607 ACACUCAAGGGAACUU GAGCGUGAAUCUGUA                                                                         ID. NO. 317                                   1618 AACUUGAGCGUGAAUCUGUAUCUUGCCGGUC                                                                          ID. NO. 318                                   1622 UGAGCGUGAAUCUGUA UCUUGCCGGUCAUUU                                                                         ID. NO. 319                                   1624 AGCGUGAAUCUGUAUCUUGCCGGUCAUUUUU                                                                          ID. NO. 320                                   1626 CGUGAAUCUGUAUCUU GCCGGUCAUUUUUAU                                                                         ID. NO. 321                                   1633 CUGUAUCUUGCCGGUCAUUUUUAUGUUAUUA                                                                          ID. NO. 322                                   1636 UAUCUUGCCGGUCAUU UUUAUGUUAUUACAG                                                                         ID. NO. 323                                   1637 AUCUUGCCGGUCAUUU UUAUGUUAUUACAGG                                                                         ID. NO. 324                                   1638 UCUUGCCGGUCAUUUU UAUGUUAUUACAGGG                                                                         ID. NO. 325                                   1639 CUUGCCGGUCAUUUUU AUGUUAUUACAGGGC                                                                         ID. NO. 326                                   1640 UUGCCGGUCAUUUUUA UGUUAUUACAGGGCA                                                                         ID. NO. 327                                   1644 CGGUCAUUUUUAUGUU AUUACAGGGCAUUCA                                                                         ID. NO. 328                                   1645 GGUCAUUUUUAUGUUA UUACAGGGCAUUCAA                                                                         ID. NO. 329                                   1647 UCAUUUUUAUGUUAUU ACAGGGCAUUCAAAU                                                                         ID. NO. 330                                   1648 CAUUUUUAUGUUAUUA CAGGGCAUUCAAAUG                                                                         ID. NO. 331                                   1657 GUUAUUACAGGGCAUU CAAAUGGGCUGCUGC                                                                         ID. NO. 332                                   1658 UUAUUACAGGGCAUUCAAAUGGGCUGCUGCU                                                                          ID. NO. 333                                   1674 AAAUGGGCUGCUGCUU AGCUUGCACCUUGUC                                                                         ID. NO. 334                                   1675 AAUGGGCUGCUGCUUA GCUUGCACCUUGUCA                                                                         ID. NO. 335                                   1679 GGCUGCUGCUUAGCUU GCACCUUGUCACAUA                                                                         ID. NO. 336                                   1686 GCUUAGCUUGCACCUU GUCACAUAGAGUGAU                                                                         ID. NO. 337                                   1689 UAGCUUGCACCUUGUCACAUAGAGUGAUCUU                                                                          ID. NO. 338                                   1694 UGCACCUUGUCACAUA GAGUGAUCUUUCCCA                                                                         ID. NO. 339                                   1702 GUCACAUAGAGUGAUCUUUCCCAAGAGAAGG                                                                          ID. NO. 340                                   1704 CACAUAGAGUGAUCUU UCCCAAGAGAAGGGG                                                                         ID. NO. 341                                   1705 ACAUAGAGUGAUCUUU CCCAAGAGAAGGGGA                                                                         ID. NO. 342                                   1706 CAUAGAGUGAUCUUUCCCAAGAGAAGGGGAA                                                                          ID. NO. 343                                   1727 AGAAGGGGAAGCACUCGUGUGCAACAGACAA                                                                          ID. NO. 344                                   1751 CAGACAAGUGACUGUA UCUGUGUAGACUAUU                                                                         ID. NO. 345                                   1753 GACAAGUGACUGUAUCUGUGUAGACUAUUUG                                                                          ID. NO. 346                                   1759 UGACUGUAUCUGUGUA GACUAUUUGCUUAUU                                                                         ID. NO. 347                                   1764 GUAUCUGUGUAGACUA UUUGCUUAUUUAAUA                                                                         ID. NO. 348                                   1766 AUCUGUGUAGACUAUU UGCUUAUUUAAUAAA                                                                         ID. NO. 349                                   1767 UCUGUGUAGACUAUUU GCUUAUUUAAUAAAG                                                                         ID. NO. 350                                   1771 UGUAGACUAUUUGCUU AUUUAAUAAAGACGA                                                                         ID. NO. 351                                   1772 GUAGACUAUUUGCUUA UUUAAUAAAGACGAU                                                                         ID. NO. 352                                   1774 AGACUAUUUGCUUAUU UAAUAAAGACGAUUU                                                                         ID. NO. 353                                   1775 GACUAUUUGCUUAUUU AAUAAAGACGAUUUG                                                                         ID. NO. 354                                   1776 ACUAUUUGCUUAUUUA AUAAAGACGAUUUGU                                                                         ID. NO. 355                                   1779 AUUUGCUUAUUUAAUA AAGACGAUUUGUCAG                                                                         ID. NO. 356                                   1788 UUUAAUAAAGACGAUU UGUCAGUUGUUUU                                                                           ID. NO. 357                                   1789 UUAAUAAAGACGAUUU GUCAGUUGUUUU                                                                            ID. NO. 358                                   1792 AUAAAGACGAUUUGUCAGUUGUUUU  ID. NO. 359                                   __________________________________________________________________________

                  TABLE IV                                                        ______________________________________                                        Human Stromelysin HP Target Sequence                                          nt                                                                            Position                                                                             Target Sequence       Seq. ID. NO.                                     ______________________________________                                         66    CUACU GUU GCUGUGCGUGGCAGU                                                                           ID. NO. 360                                       82    UGGCA GUU UGCUCAGCCUAUCCA                                                                           ID. NO. 361                                       192   AAACA GUU UGUUAGGAGAAAGGA                                                                           ID. NO. 362                                       430   AUGCU GUU GAUUCUGCUGUUGAG                                                                           ID. NO. 363                                       442   CUGCU GUU GAGAAAGCUCUGAAA                                                                           ID. NO. 364                                       775   UCACA GAC CUGACUCGGUUCCGC                                                                           ID. NO. 365                                      1360   AUGCU GUU UUUGAAGAAUUUGGG                                                                           ID. NO. 366                                      1407   UCACA GUU GGAGUUUGACCCAAA                                                                           ID. NO. 367                                      ______________________________________                                    

                                      Table V                                     __________________________________________________________________________    Human HH Ribozyme Sequence                                                    nt.                                                                           Position.                                                                          Ribozyme Sequence             Seq. ID.                                   __________________________________________________________________________     10  GUUGUCUC CUGAAGAGCACGAAAGUGCGAA AUGCCUUG                                                                    ID. NO. 375                                 21  UUAGCUC CUGAUGAGGCCGAAAGGCCGAA AUGUUGU                                                                      ID. NO. 376                                 168 GAGGUCG CUGAUGAGGCCGAAAGGCCGAA AGUAGUU                                                                      ID. NO. 377                                 616 CUCCAUU CUGAUGAGGCCGAAAGGCCGAA AUCCCUG                                                                      ID. NO. 378                                 617 UCUCCAU CUGAUGAGGCCGAAAGGCCGAA AAUCCCU                                                                      ID. NO. 379                                 633 CAUCAUCA CUGAAGAGCACGAAAGUGCGAA AGUGGGCA                                                                    ID. NO. 380                                 634 UCAUCAUC CUGAAGAGCACGAAAGUGCGAA AAGUGGGC                                                                    ID. NO. 381                                 662 CCUGUUG CUGAUGAGGCCGAAAGGCCGAA AUCCUUU                                                                      ID. NO. 382                                 711 ACCCAGG CUGAUGAGGCCGAAAGGCCGAA AGUGGCC                                                                      ID. NO. 383                                 820 GGGACUG CUGAUGAGGCCGAAAGGCCGAA AUGCCAU                                                                      ID. NO. 384                                 883 UCUGGAGG CUGAAGAGCACGAAAGUGCGAA ACAGGUUC                                                                    ID. NO. 385                                 947 CCCCUCA CUGAUGAGGCCGAAAGGCCGAA AGUGCUG                                                                      ID. NO. 386                                 996 CCUGAGG CUGAUGAGGCCGAAAGGCCGAA AUUUGCG                                                                      ID. NO. 387                                1123 UGGCCCA CUGAUGAGGCCGAAAGGCCGAA AAUUGAU                                                                      ID. NO. 388                                1132 UUUCCUCU CUGAUGAGCACGAAAGUGCGAA AUGGCCCA                                                                    ID. NO. 389                                1221 CCUUAUCA CUGAAGAGCACGAAAGUGCGAA AAAUGGCU                                                                    ID. NO. 390                                1266 UCUCCAG CUGAUGAGGCCGAAAGGCCGAA AUUUGUC                                                                      ID. NO. 391                                1275 UCUCAUCA CUGAAGAGCACGAAAGUGCGAA AUCUCCAG                                                                    ID. NO. 392                                1334 AUCCCUG CUGAUGAGGCCGAAAGGCCGAA AAAGUCU                                                                      ID. NO. 393                                1354 CAGCAUC CUGAUGAGGCCGAAAGGCCGAA AUCUUUG                                                                      ID. NO. 394                                1363 UCUUCAAA CUGAUGAGCACGAAAGUGCGAA ACAGCAUC                                                                    ID. NO. 395                                1410 AAACUCC CUGAUGAGGCCGAAAGGCCGAA ACUGUGA                                                                      ID. NO. 396                                __________________________________________________________________________

                  TABLE VI                                                        ______________________________________                                        Rabbit Stromelysin HH Ribozyme Target Sequence                                nt.                                                                           Position       Target Sequence                                                ______________________________________                                        18             CAAGGCAU C AAGACAGC                                             29            GACAGCAU A GAGCUGAG                                             39            AGCUGAGU A AAGCCAAU                                             61            UGAAAACU C UUCCAACC                                             63            AAAACUCU U CCAACCCU                                             64            AAACUCUU C CAACCCUG                                             75            ACCCUGCU A CUGCUGUG                                             93            GUGGCGCU U UGCUCAGC                                             94            UGGCGCUU U GCUCAGCC                                             98            GCUUUGCU C AGCCUAUC                                             104           CUCAGCCU A UCCACUGG                                             106           CAGCCUAU C CACUGGAU                                             122           UGGAGCCU C AAGGGAUG                                             153           AUGGACCU U CUUCAGCA                                             154           UGGACCUU C UUCAGCAA                                             156           GACCUUCU U CAGCAAUA                                             157           ACCUUCUU C AGCAAUAU                                             164           UCAGCAAU A UCUGGAAA                                             166           AGCAAUAU C UGGAAAAC                                             176           GGAAAACU A CUACAACC                                             179           AAACUACU A CAACCUUG                                             186           UACAACCU U GAAAAAGA                                             206           GAAACAGU U UGUUAAAA                                             207           AAACAGUU U GUUAAAAG                                             210           CAGUUUGU U AAAAGAAA                                             211           AGUUUGUU A AAAGAAAG                                             226           AGGACAGU A GUCCUGUU                                             229           ACAGUAGU C CUGUUGUU                                             234           AGUCCUGU U GUUAAAAA                                             237           CCUGUUGU U AAAAAAAU                                             238           CUGUUGUU A AAAAAAUC                                             246           AAAAAAAU C CAAGAAAU                                             263           GCAGAAGU U CCUUGGCU                                             264           CAGAAGUU C CUUGGCUU                                             267           AAGUUCCU U GGCUUGGA                                             272           CCUUGGCU U GGAGGUGA                                             296           GCUGGACU C CAACACCC                                             315           GAGGUGAU A CGCAAGCC                                             336           UGUGGCGU U CCUGAUGU                                             337           GUGGCGUU C CUGAUGUU                                             345           CCUGAUGU U GGUCACUU                                             349           AUGUUGGU C ACUUCAGU                                             353           UGGUCACU U CAGUACCU                                             354           GGUCACUU C AGUACCUU                                             358           ACUUCAGU A CCUUCCCU                                             362           CAGUACCU U CCCUGGCA                                             363           AGUACCUU C CCUGGCAC                                             391           CAAAAACU C ACCUAACU                                             396           ACUCACCU A ACUUACAG                                             400           ACCUAACU U ACAGGAUU                                             401           CCUAACUU A CAGGAUUG                                             408           UACAGGAU U GUGAAUUA                                             415           UUGUGAAU U ACACACCG                                             416           UGUGAAUU A CACACCGG                                             427           CACCGGAU C UGCCAAGA                                             444           GAUGCUGU U GAUGCUGC                                             456           GCUGCCAU U GAGAAAGC                                             466           AGAAAGCU C UGAAGGUC                                             474           CUGAAGGU C UGGGAGGA                                             490           AGGUGACU C CACUCACG                                             495           ACUCCACU C ACGUUCUC                                             500           ACUCACGU U CUCCAGGA                                             501           CUCACGUU C UCCAGGAA                                             503           CACGUUCU C CAGGAAGU                                             512           CAGGAAGU A UGAAGGAG                                             531           GCUGACAU A AUGAUCUC                                             537           AUAAUGAU C UCUUUUGG                                             539           AAUGAUCU C UUUUGGAG                                             541           UGAUCUCU U UUGGAGUC                                             542           GAUCUCUU U UGGAGUCC                                             543           AUCUCUUU U GGAGUCCG                                             549           UUUGGAGU C CGAGAACA                                             565           AUGGAGAU U UUAUUCCU                                             566           UGGAGAUU U UAUUCCUU                                             567           GGAGAUUU U AUUCCUUU                                             568           GAGAUUUU A UUCCUUUU                                             570           GAUUUUAU U CCUUUUGA                                             571           AUUUUAUU C CUUUUGAU                                             574           UUAUUCCU U UUGAUGGA                                             575           UAUUCCUU U UGAUGGAC                                             576           AUUCCUUU U GAUGGACC                                             594           GGAAAUGU U UUGGCUCA                                             595           GAAAUGUU U UGGCUCAU                                             596           AAAUGUUU U GGCUCAUG                                             601           UUUUGGCU C AUGCUUAU                                             607           CUCAUGCU U AUGCACCU                                             608           UCAUGCUU A UGCACCUG                                             627           CCAGGAAU U AAUGGAGA                                             628           CAGGAAUU A AUGGAGAU                                             644           UGCCCACU U UGAUGAUG                                             645           GCCCACUU U GAUGAUGA                                             673           CAAAGGAU A CAACAGGA                                             688           GAACCAAU U UAUUCCUU                                             689           AACCAAUU U AUUCCUUG                                             690           ACCAAUUU A UUCCUUGU                                             692           CAAUUUAU U CCUUGUUG                                             693           AAUUUAUU C CUUGUUGC                                             696           UUAUUCCU U GUUGCUGC                                             699           UUCCUUGU U GCUGCUCA                                             706           UUGCUGCU C AUGAGCUU                                             714           CAUGAGCU U GGCCACUC                                             722           UGGCCACU C CCUGGGUC                                             730           CCCUGGGU C UGUUUCAC                                             734           GGGUCUGU U UCACUCGG                                             735           GGUCUGUU U CACUCGGC                                             736           GUCUGUUU C ACUCGGCC                                             740           GUUUCACU C GGCCAACC                                             764           GCUGAUGU A CCCAGUCU                                             771           UACCCAGU C UACAACGC                                             773           CCCAGUCU A CAACGCCU                                             782           CAACGCCU U CACAGACC                                             783           AACGCCUU C ACAGACCU                                             800           GGCCCGGU U CCGCCUUU                                             801           GCCCGGUU C CGCCUUUC                                             807           UUCCGCCU U UCUCAAGA                                             808           UCCGCCUU U CUCAAGAU                                             809           CCGCCUUU C UCAAGAUG                                             811           GCCUUUCU C AAGAUGAU                                             831           GAUGGCAU C CAAUCCCU                                             836           CAUCCAAU C CCUCUAUG                                             840           CAAUCCCU C UAUGGACC                                             842           AUCCCUCU A UGGACCGG                                             860           CCCUGCCU C UCCUGAUA                                             862           CUGCCUCU C CUGAUAAC                                             868           CUCCUGAU A ACUCUGGA                                             872           UGAUAACU C UGGAGUGC                                             883           GAGUGCCU A UGGAACCU                                             894           GAACCUGU C CCUCCAGG                                             898           CUGUCCCU C CAGGAUCU                                             905           UCCAGGAU C UGGGACCC                                             918           ACCCCAGU C AUGUGUGA                                             928           UGUGUGAU C CAGAUCUG                                             934           AUCCAGAU C UGUCCUUC                                             938           AGAUCUGU C CUUCGAUG                                             941           UCUGUCCU U CGAUGCAA                                             942           CUGUCCUU C GAUGCAAU                                             951           GAUGCAAU C AGCACUCU                                             958           UCAGCACU C UGAGGGGA                                             972           GGAGAAAU U CUGUUCUU                                             973           GAGAAAUU C UGUUCUUU                                             977           AAUUCUGU U CUUUAAAG                                             978           AUUCUGUU C UUUAAAGA                                             980           UCUGUUCU U UAAAGACA                                             981           CUGUUCUU U AAAGACAG                                             982           UGUUCUUU A AAGACAGG                                             992           AGACAGGU A UUUCUGGC                                             994           ACAGGUAU U UCUGGCGC                                             995           CAGGUAUU U CUGGCGCA                                             996           AGGUAUUU C UGGCGCAA                                            1007           GCGCAAGU C CCUCAGGA                                            1011           AAGUCCCU C AGGAUUCU                                            1017           CUCAGGAU U CUCGAACC                                            1018           UCAGGAUU C UCGAACCU                                            1020           AGGAUUCU C GAACCUGA                                            1031           ACCUGAGU U UCAUUUGA                                            1032           CCUGAGUU U CAUUUGAU                                            1033           CUGAGUUU C AUUUGAUC                                            1036           AGUUUCAU U UGAUCUCU                                            1037           GUUUCAUU U GAUCUCUU                                            1041           CAUUUGAU C UCUUCAUU                                            1043           UUUGAUCU C UUCAUUCU                                            1045           UGAUCUCU U CAUUCUGG                                            1046           GAUCUCUU C AUUCUGGC                                            1049           CUCUUCAU U CUGGCCAU                                            1050           UCUUCAUU C UGGCCAUC                                            1058           CUGGCCAU C UCUUCCUU                                            1060           GGCCAUCU C UUCCUUCA                                            1062           CCAUCUCU U CCUUCAGC                                            1063           CAUCUCUU C CUUCAGCA                                            1066           CUCUUCCU U CAGCAGUG                                            1067           UCUUCCUU C AGCAGUGG                                            1085           UGCUGCAU A UGAAGUUA                                            1092           UAUGAAGU U AUUAGCAG                                            1093           AUGAAGUU A UUAGCAGG                                            1095           GAAGUUAU U AGCAGGGA                                            1096           AAGUUAUU A GCAGGGAU                                            1105           GCAGGGAU A CUGUUUUC                                            1110           GAUACUGU U UUCAUUUU                                            1111           AUACUGUU U UCAUUUUU                                            1112           UACUGUUU U CAUUUUUA                                            1113           ACUGUUUU C AUUUUUAA                                            1116           GUUUUCAU U UUUAAAGG                                            1117           UUUUCAUU U UUAAAGGA                                            1118           UUUCAUUU U UAAAGGAA                                            1119           UUCAUUUU U AAAGGAAC                                            1120           UCAUUUUU A AAGGAACU                                            1129           AAGGAACU C AGUUCUGG                                            1133           AACUCAGU U CUGGGCCA                                            1134           ACUCAGUU C UGGGCCAU                                            1143           UGGGCCAU U AGAGGAAA                                            1144           GGGCCAUU A GAGGAAAU                                            1158           AAUGAGGU A CAAGCUGG                                            1168           AAGCUGGU U ACCCAAGA                                            1169           AGCUGGUU A CCCAAGAA                                            1182           AGAAGCAU C CACACCCU                                            1195           CCCUGGGU U UCCCUUCA                                            1196           CCUGGGUU U CCCUUCAA                                            1197           CUGGGUUU C CCUUCAAC                                            1201           GUUUCCCU U CAACCAUA                                            1202           UUUCCCUU C AACCAUAA                                            1209           UCAACCAU A AGAAAAAU                                            1218           AGAAAAAU U GAUGCUGC                                            1230           GCUGCCAU U UCUGAUAA                                            1231           CUGCCAUU U CUGAUAAG                                            1232           UGCCAUUU C UGAUAAGG                                            1237           UUUCUGAU A AGGAAAGG                                            1256           GAAAACAU A CUUCUUUG                                            1259           AACAUACU U CUUUGUGG                                            1260           ACAUACUU C UUUGUGGA                                            1262           AUACUUCU U UGUGGAAG                                            1263           UACUUCUU U GUGGAAGA                                            1277           AGACAAAU A CUGGAGGU                                            1286           CUGGAGGU U UGAUGAGA                                            1287           UGGAGGUU U GAUGAGAA                                            1304           GAGACAGU C CCUGGAGC                                            1319           GCCAGGCU U UCCCAGAC                                            1320           CCAGGCUU U CCCAGACA                                            1321           CAGGCUUU C CCAGACAU                                            1330           CCAGACAU A UAGCAGAA                                            1332           AGACAUAU A GCAGAAGA                                            1343           AGAAGACU U UCCAGGAA                                            1344           GAAGACUU U CCAGGAAU                                            1345           AAGACUUU C CAGGAAUU                                            1353           CCAGGAAU U AAUCCAAA                                            1354           CAGGAAUU A AUCCAAAG                                            1357           GAAUUAAU C CAAAGAUC                                            1365           CCAAAGAU C GAUGCUGU                                            1374           GAUGCUGU U UUUGAAGC                                            1375           AUGCUGUU U UUGAAGCA                                            1376           UGCUGUUU U UGAAGCAU                                            1377           GCUGUUUU U GAAGCAUU                                            1385           UGAAGCAU U UGGGUUUU                                            1386           GAAGCAUU U GGGUUUUU                                            1391           AUUUGGGU U UUUCUAUU                                            1392           UUUGGGUU U UUCUAUUU                                            1393           UUGGGUUU U UCUAUUUC                                            1394           UGGGUUUU U CUAUUUCU                                            1395           GGGUUUUU C UAUUUCUU                                            1397           GUUUUUCU A UUUCUUCA                                            1399           UUUUCUAU U UCUUCAGU                                            1400           UUUCUAUU U CUUCAGUG                                            1401           UUCUAUUU C UUCAGUGG                                            1403           CUAUUUCU U CAGUGGAU                                            1404           UAUUUCUU C AGUGGAUC                                            1412           CAGUGGAU C UUCACAGU                                            1414           GUGGAUCU U CACAGUCG                                            1415           UGGAUCUU C ACAGUCGG                                            1421           UUCACAGU C GGAGUUUG                                            1427           GUCGGAGU U UGACCCAA                                            1428           UCGGAGUU U GACCCAAA                                            1458           ACACAUGU U UUGAAGAG                                            1459           CACAUGUU U UGAAGAGC                                            1460           ACAUGUUU U GAAGAGCA                                            1478           CAGCUGGU U UCAGUGUU                                            1479           AGCUGGUU U CAGUGUUA                                            1480           GCUGGUUU C AGUGUUAG                                            1486           UUCAGUGU U AGGAGGGG                                            1487           UCAGUGUU A GGAGGGGU                                            1498           AGGGGUGU A UAGAAGGC                                            1500           GGGUGUAU A GAAGGCAC                                            1519           AUGAAUGU U UUAAAUGA                                            1520           UGAAUGUU U UAAAUGAA                                            1521           GAAUGUUU U AAAUGAAC                                            1522           AAUGUUUU A AAUGAACC                                            1532           AUGAACCU A AUUGUUCA                                            1535           AACCUAAU U GUUCAACA                                            1538           CUAAUUGU U CAACACUU                                            1539           UAAUUGUU C AACACUUA                                            1546           UCAACACU U AGGACUUU                                            1547           CAACACUU A GGACUUUG                                            1553           UUAGGACU U UGUGAGUU                                            1554           UAGGACUU U GUGAGUUG                                            1561           UUGUGAGU U GAAGUGGC                                            1571           AAGUGGCU C AUUUUCUC                                            1574           UGGCUCAU U UUCUCCUG                                            1575           GGCUCAUU U UCUCCUGC                                            1576           GCUCAUUU U CUCCUGCA                                            1577           CUCAUUUU C UCCUGCAU                                            1579           CAUUUUCU C CUGCAUAU                                            1586           UCCUGCAU A UGCUGUGA                                            1602           AUGGGAAU C UCGAGCAU                                            1604           GGGAAUCU C GAGCAUGA                                            1620           AACUGUGU A UCUAACUG                                            1622           CUGUGUAU C UAACUGGA                                            1624           GUGUAUCU A ACUGGACU                                            1633           ACUGGACU U UGCACAUC                                            1634           CUGGACUU U GCACAUCG                                            1641           UUGCACAU C GUUACGGG                                            1644           CACAUCGU U ACGGGUGU                                            1645           ACAUCGUU A CGGGUGUU                                            1653           ACGGGUGU U CAAACAGG                                            1654           CGGGUGUU C AAACAGGC                                            1670           CUGCUGCU U AGCUUGCA                                            1671           UGCUGCUU A GCUUGCAC                                            1675           GCUUAGCU U GCACUUGA                                            1681           CUUGCACU U GAUCACAU                                            1685           CACUUGAU C ACAUGGAA                                            1701           AGGGAGCU U CCACGAGA                                            1702           GGGAGCUU C CACGAGAC                                            1720           GGGGAAGU A CUCAUGUG                                            1723           GAAGUACU C AUGUGUGA                                            1744           CGAGUGAU U GUGUCUAU                                            1749           GAUUGUGU C UAUGUGGA                                            1751           UUGUGUCU A UGUGGAUU                                            1759           AUGUGGAU U AUUUGCCC                                            1760           UGUGGAUU A UUUGCCCA                                            1762           UGGAUUAU U UGCCCAUU                                            1763           GGAUUAUU U GCCCAUUA                                            1770           UUGCCCAU U AUUUAAUA                                            1771           UGCCCAUU A UUUAAUAA                                            1773           CCCAUUAU U UAAUAAAG                                            1774           CCAUUAUU U AAUAAAGA                                            1775           CAUUAUUU A AUAAAGAG                                            1778           UAUUUAAU A AAGAGGAU                                            1787           AAGAGGAU U UGUCAAUU                                            ______________________________________                                    

                                      TABLE VII                                   __________________________________________________________________________    Rabbit Stromelysin HH Ribozyme Sequence                                       nt.                                                                           Position                                                                             Ribozyme Sequence                                                      __________________________________________________________________________    18     GCUGUCUU CUGAUGAGGCCGAAAGGCCGAA AUGCCUUG                               29     CUCAGCUC CUGAUGAGGCCGAAAGGCCGAA AUGCUGUC                               39     AUUGGCUU CUGAUGAGGCCGAAAGGCCGAA ACUCAGCU                               61     GGUUGGAA CUGAUGAGGCCGAAAGGCCGAA AGUUUUCA                               63     AGGGUUGG CUGAUGAGGCCGAAAGGCCGAA AGAGUUUU                               64     CAGGGUUG CUGAUGAGGCCGAAAGGCCGAA AAGAGUUU                               75     CACAGCAG CUGAUGAGGCCGAAAGGCCGAA AGCAGGGU                               93     GCUGAGCA CUGAUGAGGCCGAAAGGCCGAA AGCGCCAC                               94     GGCUGAGC CUGAUGAGGCCGAAAGGCCGAA AAGCGCCA                               98     GAUAGGCU CUGAUGAGGCCGAAAGGCCGAA AGCAAAGC                               104    CCAGUGGA CUGAUGAGGCCGAAAGGCCGAA AGGCUGAG                               106    AUCCAGUG CUGAUGAGGCCGAAAGGCCGAA AUAGGCUG                               122    CAUCCCUU CUGAUGAGGCCGAAAGGCCGAA AGGCUCCA                               153    UGCUGAAG CUGAUGAGGCCGAAAGGCCGAA AGGUCCAU                               154    UUGCUGAA CUGAUGAGGCCGAAAGGCCGAA AAGGUCCA                               156    UAUUGCUG CUGAUGAGGCCGAAAGGCCGAA AGAAGGUC                               157    AUAUUGCU CUGAUGAGGCCGAAAGGCCGAA AAGAAGGU                               164    UUUCCAGA CUGAUGAGGCCGAAAGGCCGAA AUUGCUGA                               166    GUUUUCCA CUGAUGAGGCCGAAAGGCCGAA AUAUUGCU                               176    GGUUGUAG CUGAUGAGGCCGAAAGGCCGAA AGUUUUCC                               179    CAAGGUUG CUGAUGAGGCCGAAAGGCCGAA AGUAGUUU                               186    UCUUUUUC CUGAUGAGGCCGAAAGGCCGAA AGGUUGUA                               206    UUUUAACA CUGAUGAGGCCGAAAGGCCGAA ACUGUUUC                               207    CUUUUAAC CUGAUGAGGCCGAAAGGCCGAA AACUGUUU                               210    UUUCUUUU CUGAUGAGGCCGAAAGGCCGAA ACAAACUG                               211    CUUUCUUU CUGAUGAGGCCGAAAGGCCGAA AACAAACU                               226    AACAGGAC CUGAUGAGGCCGAAAGGCCGAA ACUGUCCU                               229    AACAACAG CUGAUGAGGCCGAAAGGCCGAA ACUACUGU                               234    UUUUUAAC CUGAUGAGGCCGAAAGGCCGAA ACAGGACU                               237    AUUUUUUU CUGAUGAGGCCGAAAGGCCGAA ACAACAGG                               238    GAUUUUUU CUGAUGAGGCCGAAAGGCCGAA AACAACAG                               246    AUUUCUUG CUGAUGAGGCCGAAAGGCCGAA AUUUUUUU                               263    AGCCAAGG CUGAUGAGGCCGAAAGGCCGAA ACUUCUGC                               264    AAGCCAAG CUGAUGAGGCCGAAAGGCCGAA AACUUCUG                               267    UCCAAGCC CUGAUGAGGCCGAAAGGCCGAA AGGAACUU                               272    UCACCUCC CUGAUGAGGCCGAAAGGCCGAA AGCCAAGG                               296    GGGUGUUG CUGAUGAGGCCGAAAGGCCGAA AGUCCAGC                               315    GGCUUGCG CUGAUGAGGCCGAAAGGCCGAA AUCACCUC                               336    ACAUCAGG CUGAUGAGGCCGAAAGGCCGAA ACGCCACA                               337    AACAUCAG CUGAUGAGGCCGAAAGGCCGAA AACGCCAC                               345    AAGUGACC CUGAUGAGGCCGAAAGGCCGAA ACAUCAGG                               349    ACUGAAGU CUGAUGAGGCCGAAAGGCCGAA ACCAACAU                               353    AGGUACUG CUGAUGAGGCCGAAAGGCCGAA AGUGACCA                               354    AAGGUACU CUGAUGAGGCCGAAAGGCCGAA AAGUGACC                               358    AGGGAAGG CUGAUGAGGCCGAAAGGCCGAA ACUGAAGU                               362    UGCCAGGG CUGAUGAGGCCGAAAGGCCGAA AGGUACUG                               363    GUGCCAGG CUGAUGAGGCCGAAAGGCCGAA AAGGUACU                               391    AGUUAGGU CUGAUGAGGCCGAAAGGCCGAA AGUUUUUG                               396    CUGUAAGU CUGAUGAGGCCGAAAGGCCGAA AGGUGAGU                               400    AAUCCUGU CUGAUGAGGCCGAAAGGCCGAA AGUUAGGU                               401    CAAUCCUG CUGAUGAGGCCGAAAGGCCGAA AAGUUAGG                               408    UAAUUCAC CUGAUGAGGCCGAAAGGCCGAA AUCCUGUA                               415    CGGUGUGU CUGAUGAGGCCGAAAGGCCGAA AUUCACAA                               416    CCGGUGUG CUGAUGAGGCCGAAAGGCCGAA AAUUCACA                               427    UCUUGGCA CUGAUGAGGCCGAAAGGCCGAA AUCCGGUG                               444    GCAGCAUC CUGAUGAGGCCGAAAGGCCGAA ACAGCAUC                               456    GCUUUCUC CUGAUGAGGCCGAAAGGCCGAA AUGGCAGC                               466    GACCUUCA CUGAUGAGGCCGAAAGGCCGAA AGCUUUCU                               474    UCCUCCCA CUGAUGAGGCCGAAAGGCCGAA ACCUUCAG                               490    CGUGAGUG CUGAUGAGGCCGAAAGGCCGAA AGUCACCU                               495    GAGAACGU CUGAUGAGGCCGAAAGGCCGAA AGUGGAGU                               500    UCCUGGAG CUGAUGAGGCCGAAAGGCCGAA ACGUGAGU                               501    UUCCUGGA CUGAUGAGGCCGAAAGGCCGAA AACGUGAG                               503    ACUUCCUG CUGAUGAGGCCGAAAGGCCGAA AGAACGUG                               512    CUCCUUCA CUGAUGAGGCCGAAAGGCCGAA ACUUCCUG                               531    GAGAUCAU CUGAUGAGGCCGAAAGGCCGAA AUGUCAGC                               537    CCAAAAGA CUGAUGAGGCCGAAAGGCCGAA AUCAUUAU                               539    CUCCAAAA CUGAUGAGGCCGAAAGGCCGAA AGAUCAUU                               541    GACUCCAA CUGAUGAGGCCGAAAGGCCGAA AGAGAUCA                               542    GGACUCCA CUGAUGAGGCCGAAAGGCCGAA AAGAGAUC                               543    CGGACUCC CUGAUGAGGCCGAAAGGCCGAA AAAGAGAU                               549    UGUUCUCG CUGAUGAGGCCGAAAGGCCGAA ACUCCAAA                               565    AGGAAUAA CUGAUGAGGCCGAAAGGCCGAA AUCUCCAU                               566    AAGGAAUA CUGAUGAGGCCGAAAGGCCGAA AAUCUCCA                               567    AAAGGAAU CUGAUGAGGCCGAAAGGCCGAA AAAUCUCC                               568    AAAAGGAA CUGAUGAGGCCGAAAGGCCGAA AAAAUCUC                               570    UCAAAAGG CUGAUGAGGCCGAAAGGCCGAA AUAAAAUC                               571    AUCAAAAG CUGAUGAGGCCGAAAGGCCGAA AAUAAAAU                               574    UCCAUCAA CUGAUGAGGCCGAAAGGCCGAA AGGAAUAA                               575    GUCCAUCA CUGAUGAGGCCGAAAGGCCGAA AAGGAAUA                               576    GGUCCAUC CUGAUGAGGCCGAAAGGCCGAA AAAGGAAU                               594    UGAGCCAA CUGAUGAGGCCGAAAGGCCGAA ACAUUUCC                               595    AUGAGCCA CUGAUGAGGCCGAAAGGCCGAA AACAUUUC                               596    CAUGAGCC CUGAUGAGGCCGAAAGGCCGAA AAACAUUU                               601    AUAAGCAU CUGAUGAGGCCGAAAGGCCGAA AGCCAAAA                               607    AGGUGCAU CUGAUGAGGCCGAAAGGCCGAA AGCAUGAG                               608    CAGGUGCA CUGAUGAGGCCGAAAGGCCGAA AAGCAUGA                               627    UCUCCAUU CUGAUGAGGCCGAAAGGCCGAA AUUCCUGG                               628    AUCUCCAU CUGAUGAGGCCGAAAGGCCGAA AAUUCCUG                               644    CAUCAUCA CUGAUGAGGCCGAAAGGCCGAA AGUCGGCA                               645    UCAUCAUC CUGAUGAGGCCGAAAGGCCGAA AAGUGGGC                               673    UCCUGUUG CUGAUGAGGCCGAAAGGCCGAA AUCCUUUG                               688    AAGGAAUA CUGAUGAGGCCGAAAGGCCGAA AUUGGUUC                               689    CAAGGAAU CUGAUGAGGCCGAAAGGCCGAA AAUUGGUU                               690    ACAAGGAA CUGAUGAGGCCGAAAGGCCGAA AAAUUGGU                               692    CAACAAGG CUGAUGAGGCCGAAAGGCCGAA AUAAAUUG                               693    GCAACAAG CUGAUGAGGCCGAAAGGCCGAA AAUAAAUU                               696    GCAGCAAC CUGAUGAGGCCGAAAGGCCGAA AGGAAUAA                               699    UGAGCAGC CUGAUGAGGCCGAAAGGCCGAA ACAAGGAA                               706    AAGCUCAU CUGAUGAGGCCGAAAGGCCGAA AGCAGCAA                               714    GAGUGGCC CUGAUGAGGCCGAAAGGCCGAA AGCUCAUG                               722    GACCCAGG CUGAUGAGGCCGAAAGGCCGAA AGUGGCCA                               730    GUGAAACA CUGAUGAGGCCGAAAGGCCGAA ACCCAGGG                               734    CCGAGUGA CUGAUGAGGCCGAAAGGCCGAA ACAGACCC                               735    GCCGAGUG CUGAUGAGGCCGAAAGGCCGAA AACAGACC                               736    GGCCGAGU CUGAUGAGGCCGAAAGGCCGAA AAACAGAC                               740    GGUUGGCC CUGAUGAGGCCGAAAGGCCGAA AGUGAAAC                               764    AGACUGGG CUGAUGAGGCCGAAAGGCCGAA ACAUCAGC                               771    GCGUUGUA CUGAUGAGGCCGAAAGGCCGAA ACUGGGUA                               773    AGGCGUUG CUGAUGAGGCCGAAAGGCCGAA AGACUGGG                               782    GGUCUGUG CUGAUGAGGCCGAAAGGCCGAA AGGCGUUG                               783    AGGUCUGU CUGAUGAGGCCGAAAGGCCGAA AAGGCGUU                               800    AAAGGCGG CUGAUGAGGCCGAAAGGCCGAA ACCGGGCC                               801    GAAAGGCG CUGAUGAGGCCGAAAGGCCGAA AACCGGGC                               807    UCUUGAGA CUGAUGAGGCCGAAAGGCCGAA AGGCGGAA                               808    AUCUUGAG CUGAUGAGGCCGAAAGGCCGAA AAGGCGGA                               809    CAUCUUGA CUGAUGAGGCCGAAAGGCCGAA AAAGGCGG                               811    AUCAUCUU CUGAUGAGGCCGAAAGGCCGAA AGAAAGGC                               831    AGGGAUUG CUGAUGAGGCCGAAAGGCCGAA AUGCCAUC                               836    CAUAGAGG CUGAUGAGGCCGAAAGGCCGAA AUUGGAUG                               840    GGUCCAUA CUGAUGAGGCCGAAAGGCCGAA AGGGAUUG                               842    CCGGUCCA CUGAUGAGGCCGAAAGGCCGAA AGAGGGAU                               860    UAUCAGGA CUGAUGAGGCCGAAAGGCCGAA AGGCAGGG                               862    GUUAUCAG CUGAUGAGGCCGAAAGGCCGAA AGAGGCAG                               868    UCCAGAGU CUGAUGAGGCCGAAAGGCCGAA AUCAGGAG                               872    GCACUCCA CUGAUGAGGCCGAAAGGCCGAA AGUUAUCA                               883    AGGUUCCA CUGAUGAGGCCGAAAGGCCGAA AGGCACUC                               894    CCUGGAGG CUGAUGAGGCCGAAAGGCCGAA ACAGGUUC                               898    AGAUCCUG CUGAUGAGGCCGAAAGGCCGAA AGGGACAG                               905    GGGUCCCA CUGAUGAGGCCGAAAGGCCGAA AUCCUGGA                               918    UCACACAU CUGAUGAGGCCGAAAGGCCGAA ACUGGGGU                               928    CAGAUCUG CUGAUGAGGCCGAAAGGCCGAA AUCACACA                               934    GAAGGACA CUGAUGAGGCCGAAAGGCCGAA AUCUGGAU                               938    CAUCGAAG CUGAUGAGGCCGAAAGGCCGAA ACAGAUCU                               941    UUGCAUCG CUGAUGAGGCCGAAAGGCCGAA AGGACAGA                               942    AUUGCAUC CUGAUGAGGCCGAAAGGCCGAA AAGGACAG                               951    AGAGUGCU CUGAUGAGGCCGAAAGGCCGAA AUUGCAUC                               958    UCCCCUCA CUGAUGAGGCCGAAAGGCCGAA AGUGCUGA                               972    AAGAACAG CUGAUGAGGCCGAAAGGCCGAA AUUUCUCC                               973    AAAGAACA CUGAUGAGGCCGAAAGGCCGAA AAUUUCUC                               977    CUUUAAAG CUGAUGAGGCCGAAAGGCCGAA ACAGAAUU                               978    UCUUUAAA CUGAUGAGGCCGAAAGGCCGAA AACAGAAU                               980    UGUCUUUA CUGAUGAGGCCGAAAGGCCGAA AGAACAGA                               981    CUGUCUUU CUGAUGAGGCCGAAAGGCCGAA AAGAACAG                               982    CCUGUCUU CUGAUGAGGCCGAAAGGCCGAA AAAGAACA                               992    GCCAGAAA CUGAUGAGGCCGAAAGGCCGAA ACCUGUCU                               994    GCGCCAGA CUGAUGAGGCCGAAAGGCCGAA AUACCUGU                               995    UGCGCCAG CUGAUGAGGCCGAAAGGCCGAA AAUACCUG                               996    UUGCGCCA CUGAUGAGGCCGAAAGGCCGAA AAAUACCU                               1007   UCCUGAGG CUGAUGAGGCCGAAAGGCCGAA ACUUGCGC                               1011   AGAAUCCU CUGAUGAGGCCGAAAGGCCGAA AGGGACUU                               1017   GGUUCGAG CUGAUGAGGCCGAAAGGCCGAA AUCCUGAG                               1018   AGGUUCGA CUGAUGAGGCCGAAAGGCCGAA AAUCCUGA                               1020   UCAGGUUC CUGAUGAGGCCGAAAGGCCGAA AGAAUCCU                               1031   UCAAAUGA CUGAUGAGGCCGAAAGGCCGAA ACUCAGGU                               1032   AUCAAAUG CUGAUGAGGCCGAAAGGCCGAA AACUCAGG                               1033   GAUCAAAU CUGAUGAGGCCGAAAGGCCGAA AAACUCAG                               1036   AGAGAUCA CUGAUGAGGCCGAAAGGCCGAA AUGAAACU                               1037   AAGAGAUC CUGAUGAGGCCGAAAGGCCGAA AAUGAAAC                               1041   AAUGAAGA CUGAUGAGGCCGAAAGGCCGAA AUCAAAUG                               1043   AGAAUGAA CUGAUGAGGCCGAAAGGCCGAA AGAUCAAA                               1045   CCAGAAUG CUGAUGAGGCCGAAAGGCCGAA AGAGAUCA                               1046   GCCAGAAU CUGAUGAGGCCGAAAGGCCGAA AAGAGAUC                               1049   AUGGCCAG CUGAUGAGGCCGAAAGGCCGAA AUGAAGAG                               1050   GAUGGCCA CUGAUGAGGCCGAAAGGCCGAA AAUGAAGA                               1058   AAGGAAGA CUGAUGAGGCCGAAAGGCCGAA AUGGCCAG                               1060   UGAAGGAA CUGAUGAGGCCGAAAGGCCGAA AGAUGGCC                               1062   GCUGAAGG CUGAUGAGGCCGAAAGGCCGAA AGAGAUGG                               1063   UGCUGAAG CUGAUGAGGCCGAAAGGCCGAA AAGAGAUG                               1066   CACUGCUG CUGAUGAGGCCGAAAGGCCGAA AGGAAGAG                               1067   CCACUGCU CUGAUGAGGCCGAAAGGCCGAA AAGGAAGA                               1085   UAACUUCA CUGAUGAGGCCGAAAGGCCGAA AUGCAGCA                               1092   CUGCUAAU CUGAUGAGGCCGAAAGGCCGAA ACUUCAUA                               1093   CCUGCUAA CUGAUGAGGCCGAAAGGCCGAA AACUUCAU                               1095   UCCCUGCU CUGAUGAGGCCGAAAGGCCGAA AUAACUUC                               1096   AUCCCUGC CUGAUGAGGCCGAAAGGCCGAA AAUAACUU                               1105   GAAAACAG CUGAUGAGGCCGAAAGGCCGAA AUCCCUGC                               1110   AAAAUGAA CUGAUGAGGCCGAAAGGCCGAA ACAGUAUC                               1111   AAAAAUGA CUGAUGAGGCCGAAAGGCCGAA AACAGUAU                               1112   UAAAAAUG CUGAUGAGGCCGAAAGGCCGAA AAACAGUA                               1113   UUAAAAAU CUGAUGAGGCCGAAAGGCCGAA AAAACAGU                               1116   CCUUUAAA CUGAUGAGGCCGAAAGGCCGAA AUGAAAAC                               1117   UCCUUUAA CUGAUGAGGCCGAAAGGCCGAA AAUGAAAA                               1118   UUCCUUUA CUGAUGAGGCCGAAAGGCCGAA AAAUGAAA                               1119   GUUCCUUU CUGAUGAGGCCGAAAGGCCGAA AAAAUGAA                               1120   AGUUCCUU CUGAUGAGGCCGAAAGGCCGAA AAAAAUGA                               1129   CCAGAACU CUGAUGAGGCCGAAAGGCCGAA AGUUCCUU                               1133   UGGCCCAG CUGAUGAGGCCGAAAGGCCGAA ACUGAGUU                               1134   AUGGCCCA CUGAUGAGGCCGAAAGGCCGAA AACUGAGU                               1143   UUUCCUCU CUGAUGAGGCCGAAAGGCCGAA AUGGCCCA                               1144   AUUUCCUC CUGAUGAGGCCGAAAGGCCGAA AAUGGCCC                               1158   CCAGCUUG CUGAUGAGGCCGAAAGGCCGAA ACCUCAUU                               1168   UCUUGGGU CUGAUGAGGCCGAAAGGCCGAA ACCAGCUU                               1169   UUCUUGGG CUGAUGAGGCCGAAAGGCCGAA AACCAGCU                               1182   AGGGUGUG CUGAUGAGGCCGAAAGGCCGAA AUGCUUCU                               1195   UGAAGGGA CUGAUGAGGCCGAAAGGCCGAA ACCCAGGG                               1196   UUGAAGGG CUGAUGAGGCCGAAAGGCCGAA AACCCAGG                               1197   GUUGAAGG CUGAUGAGGCCGAAAGGCCGAA AAACCCAG                               1201   UAUGGUUG CUGAUGAGGCCGAAAGGCCGAA AGGGAAAC                               1202   UUAUGGUU CUGAUGAGGCCGAAAGGCCGAA AAGGGAAA                               1209   AUUUUUCU CUGAUGAGGCCGAAAGGCCGAA AUGGUUGA                               1218   GCAGCAUC CUGAUGAGGCCGAAAGGCCGAA AUUUUUCU                               1230   UUAUCAGA CUGAUGAGGCCGAAAGGCCGAA AUGGCAGC                               1231   CUUAUCAG CUGAUGAGGCCGAAAGGCCGAA AAUGGCAG                               1232   CCUUAUCA CUGAUGAGGCCGAAAGGCCGAA AAAUGGCA                               1237   CCUUUCCU CUGAUGAGGCCGAAAGGCCGAA AUCAGAAA                               1256   CAAAGAAG CUGAUGAGGCCGAAAGGCCGAA AUGUUUUC                               1259   CCACAAAG CUGAUGAGGCCGAAAGGCCGAA AGUAUGUU                               1260   UCCACAAA CUGAUGAGGCCGAAAGGCCGAA AAGUAUGU                               1262   CUUCCACA CUGAUGAGGCCGAAAGGCCGAA AGAAGUAU                               1263   UCUUCCAC CUGAUGAGGCCGAAAGGCCGAA AAGAAGUA                               1277   ACCUCCAG CUGAUGAGGCCGAAAGGCCGAA AUUUGUCU                               1286   UCUCAUCA CUGAUGAGGCCGAAAGGCCGAA ACCUCCAG                               1287   UUCUCAUC CUGAUGAGGCCGAAAGGCCGAA AACCUCCA                               1304   GCUCCAGG CUGAUGAGGCCGAAAGGCCGAA ACUGUCUC                               1319   GUCUGGGA CUGAUGAGGCCGAAAGGCCGAA AGCCUGGC                               1320   UGUCUGGG CUGAUGAGGCCGAAAGGCCGAA AAGCCUGG                               1321   AUGUCUGG CUGAUGAGGCCGAAAGGCCGAA AAAGCCUG                               1330   UUCUGCUA CUGAUGAGGCCGAAAGGCCGAA AUGUCUGG                               1332   UCUUCUGC CUGAUGAGGCCGAAAGGCCGAA AUAUGUCU                               1343   UUCCUGGA CUGAUGAGGCCGAAAGGCCGAA AGUCUUCU                               1344   AUUCCUGG CUGAUGAGGCCGAAAGGCCGAA AAGUCUUC                               1345   AAUUCCUG CUGAUGAGGCCGAAAGGCCGAA AAAGUCUU                               1353   UUUGGAUU CUGAUGAGGCCGAAAGGCCGAA AUUCCUGG                               1354   CUUUGGAU CUGAUGAGGCCGAAAGGCCGAA AAUUCCUG                               1357   GAUCUUUG CUGAUGAGGCCGAAAGGCCGAA AUUAAUUC                               1365   ACAGCAUC CUGAUGAGGCCGAAAGGCCGAA AUCUUUGG                               1374   GCUUCAAA CUGAUGAGGCCGAAAGGCCGAA ACAGCAUC                               1375   UGCUUCAA CUGAUGAGGCCGAAAGGCCGAA AACAGCAU                               1376   AUGCUUCA CUGAUGAGGCCGAAAGGCCGAA AAACAGCA                               1377   AAUGCUUC CUGAUGAGGCCGAAAGGCCGAA AAAACAGC                               1385   AAAACCCA CUGAUGAGGCCGAAAGGCCGAA AUGCUUCA                               1386   AAAAACCC CUGAUGAGGCCGAAAGGCCGAA AAUGCUUC                               1391   AAUAGAAA CUGAUGAGGCCGAAAGGCCGAA ACCCAAAU                               1392   AAAUAGAA CUGAUGAGGCCGAAAGGCCGAA AACCCAAA                               1393   GAAAUAGA CUGAUGAGGCCGAAAGGCCGAA AAACCCAA                               1394   AGAAAUAG CUGAUGAGGCCGAAAGGCCGAA AAAACCCA                               1395   AAGAAAUA CUGAUGAGGCCGAAAGGCCGAA AAAAACCC                               1397   UGAAGAAA CUGAUGAGGCCGAAAGGCCGAA AGAAAAAC                               1399   ACUGAAGA CUGAUGAGGCCGAAAGGCCGAA AUAGAAAA                               1400   CACUGAAG CUGAUGAGGCCGAAAGGCCGAA AAUAGAAA                               1401   CCACUGAA CUGAUGAGGCCGAAAGGCCGAA AAAUAGAA                               1403   AUCCACUG CUGAUGAGGCCGAAAGGCCGAA AGAAAUAG                               1404   GAUCCACU CUGAUGAGGCCGAAAGGCCGAA AAGAAAUA                               1412   ACUGUGAA CUGAUGAGGCCGAAAGGCCGAA AUCCACUG                               1414   CGACUGUG CUGAUGAGGCCGAAAGGCCGAA AGAUCCAC                               1415   CCGACUGU CUGAUGAGGCCGAAAGGCCGAA AAGAUCCA                               1421   CAAACUCC CUGAUGAGGCCGAAAGGCCGAA ACUGUGAA                               1427   UUGGGUCA CUGAUGAGGCCGAAAGGCCGAA ACUCCGAC                               1428   UUUGGGUC CUGAUGAGGCCGAAAGGCCGAA AACUCCGA                               1458   CUCUUCAA CUGAUGAGGCCGAAAGGCCGAA ACAUGUGU                               1459   GCUCUUCA CUGAUGAGGCCGAAAGGCCGAA AACAUGUG                               1460   UGCUCUUC CUGAUGAGGCCGAAAGGCCGAA AAACAUGU                               1478   AACACUGA CUGAUGAGGCCGAAAGGCCGAA ACCAGCUG                               1479   UAACACUG CUGAUGAGGCCGAAAGGCCGAA AACCAGCU                               1480   CUAACACU CUGAUGAGGCCGAAAGGCCGAA AAACCAGC                               1486   CCCCUCCU CUGAUGAGGCCGAAAGGCCGAA ACACUGAA                               1487   ACCCCUCC CUGAUGAGGCCGAAAGGCCGAA AACACUGA                               1498   GCCUUCUA CUGAUGAGGCCGAAAGGCCGAA ACACCCCU                               1500   GUGCCUUC CUGAUGAGGCCGAAAGGCCGAA AUACACCC                               1519   UCAUUUAA CUGAUGAGGCCGAAAGGCCGAA ACAUUCAU                               1520   UUCAUUUA CUGAUGAGGCCGAAAGGCCGAA AACAUUCA                               1521   GUUCAUUU CUGAUGAGGCCGAAAGGCCGAA AAACAUUC                               1522   GGUUCAUU CUGAUGAGGCCGAAAGGCCGAA AAAACAUU                               1532   UGAACAAU CUGAUGAGGCCGAAAGGCCGAA AGGUUCAU                               1535   UGUUGAAC CUGAUGAGGCCGAAAGGCCGAA AUUAGGUU                               1538   AAGUGUUG CUGAUGAGGCCGAAAGGCCGAA ACAAUUAG                               1539   UAAGUGUU CUGAUGAGGCCGAAAGGCCGAA AACAAUUA                               1546   AAAGUCCU CUGAUGAGGCCGAAAGGCCGAA AGUGUUGA                               1547   CAAAGUCC CUGAUGAGGCCGAAAGGCCGAA AAGUGUUG                               1553   AACUCACA CUGAUGAGGCCGAAAGGCCGAA AGUCCUAA                               1554   CAACUCAC CUGAUGAGGCCGAAAGGCCGAA AAGUCCUA                               1561   GCCACUUC CUGAUGAGGCCGAAAGGCCGAA ACUCACAA                               1571   GAGAAAAU CUGAUGAGGCCGAAAGGCCGAA AGCCACUU                               1574   CAGGAGAA CUGAUGAGGCCGAAAGGCCGAA AUGAGCCA                               1575   GCAGGAGA CUGAUGAGGCCGAAAGGCCGAA AAUGAGCC                               1576   UGCAGGAG CUGAUGAGGCCGAAAGGCCGAA AAAUGAGC                               1577   AUGCAGGA CUGAUGAGGCCGAAAGGCCGAA AAAAUGAG                               1579   AUAUGCAG CUGAUGAGGCCGAAAGGCCGAA AGAAAAUG                               1586   UCACAGCA CUGAUGAGGCCGAAAGGCCGAA AUGCAGGA                               1602   AUGCUCGA CUGAUGAGGCCGAAAGGCCGAA AUUCCCAU                               1604   UCAUGCUC CUGAUGAGGCCGAAAGGCCGAA AGAUUCCC                               1620   CAGUUAGA CUGAUGAGGCCGAAAGGCCGAA ACACAGUU                               1622   UCCAGUUA CUGAUGAGGCCGAAAGGCCGAA AUACACAG                               1624   AGUCCAGU CUGAUGAGGCCGAAAGGCCGAA AGAUACAC                               1633   GAUGUGCA CUGAUGAGGCCGAAAGGCCGAA AGUCCAGU                               1634   CGAUGUGC CUGAUGAGGCCGAAAGGCCGAA AAGUCCAG                               1641   CCCGUAAC CUGAUGAGGCCGAAAGGCCGAA AUGUGCAA                               1644   ACACCCGU CUGAUGAGGCCGAAAGGCCGAA ACGAUGUG                               1645   AACACCCG CUGAUGAGGCCGAAAGGCCGAA AACGAUGU                               1653   CCUGUUUG CUGAUGAGGCCGAAAGGCCGAA ACACCCGU                               1654   GCCUGUUU CUGAUGAGGCCGAAAGGCCGAA AACACCCG                               1670   UGCAAGCU CUGAUGAGGCCGAAAGGCCGAA AGCAGCAG                               1671   GUGCAAGC CUGAUGAGGCCGAAAGGCCGAA AAGCAGCA                               1675   UCAAGUGC CUGAUGAGGCCGAAAGGCCGAA AGCUAAGC                               1681   AUGUGAUC CUGAUGAGGCCGAAAGGCCGAA AGUGCAAG                               1685   UUCCAUGU CUGAUGAGGCCGAAAGGCCGAA AUCAAGUG                               1701   UCUCGUGG CUGAUGAGGCCGAAAGGCCGAA AGCUCCCU                               1702   GUCUCGUG CUGAUGAGGCCGAAAGGCCGAA AAGCUCCC                               1720   CACAUGAG CUGAUGAGGCCGAAAGGCCGAA ACUUCCCC                               1723   UCACACAU CUGAUGAGGCCGAAAGGCCGAA AGUACUUC                               1744   AUAGACAC CUGAUGAGGCCGAAAGGCCGAA AUCACUCG                               1749   UCCACAUA CUGAUGAGGCCGAAAGGCCGAA ACACAAUC                               1751   AAUCCACA CUGAUGAGGCCGAAAGGCCGAA AGACACAA                               1759   GGGCAAAU CUGAUGAGGCCGAAAGGCCGAA AUCCACAU                               1760   UGGGCAAA CUGAUGAGGCCGAAAGGCCGAA AAUCCACA                               1762   AAUGGGCA CUGAUGAGGCCGAAAGGCCGAA AUAAUCCA                               1763   UAAUGGGC CUGAUGAGGCCGAAAGGCCGAA AAUAAUCC                               1770   UAUUAAAU CUGAUGAGGCCGAAAGGCCGAA AUGGGCAA                               1771   UUAUUAAA CUGAUGAGGCCGAAAGGCCGAA AAUGGGCA                               1773   CUUUAUUA CUGAUGAGGCCGAAAGGCCGAA AUAAUGGG                               1774   UCUUUAUU CUGAUGAGGCCGAAAGGCCGAA AAUAAUGG                               1775   CUCUUUAU CUGAUGAGGCCGAAAGGCCGAA AAAUAAUG                               1778   AUCCUCUU CUGAUGAGGCCGAAAGGCCGAA AUUAAAUA                               1787   AAUUGACA CUGAUGAGGCCGAAAGGCCGAA AUCCUCUU                               __________________________________________________________________________

                                      TABLE VIII                                  __________________________________________________________________________    Human Stromelysin Hairpin Ribozyme and Target Sequences                       nt.                                                                           Position                                                                            RZ                                        Substrate                     __________________________________________________________________________    66    CGCACAGC AGAA GUAGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UCCUACU GUU GCUGUGCG          82    GCUGAGCA AGAA GCCACG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CGUGGCA GUU UGCUCAGC          91    AAUGGAUA AGAA GAGCAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UUGCUCA GCC UAUCCAUU          192   UCCUAACA AGAA GUUUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGAAACA GUU UGUUAGGA          220   UUUUUAAC AGAA GGACCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGGUCCU GUU GUUAAAAA          328   UGACCAAC AGAA GGAACU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AGUUCCU GAU GUUGGUCA          412   UUUGGCAA AGAA GGUGUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UACACCA GAU UUGCCAAA          430   GCAGAAUC AGAA GCAUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AGAUGCU GUU GAUUCUGC          439   UUCUCAAC AGAA GAAUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGAUUCU GCU GUUGAGAA          442   GCUUUCUC AGAA GCAGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UUCUGCU GUU GAGAAAGC          691   AUUUCAUG AGAA GCAACG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CGUUGCU GCU CAUGAAAU          775   CGAGUCAG AGAA GUGAGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               ACUCACA GAC CUGACUCG          780   GGAACCGA AGAA GGUCUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CAGACCU GAC UCGGUUCC          786   ACAGGCGG AGAA GAGUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGACUCG GUU CCGCCUGU          791   UUGAGACA AGAA GAACCG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CGGUUCC GCC UGUCUCAA          795   CAUCUUGA AGAA GGCGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UCCGCCU GUC UCAAGAUG          822   CAUAGAGG AGAA GAAUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GCAUUCA GUC CCUCUAUG          844   UCAGGGGA AGAA GGGGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UCCCCCU GAC UCCCCUGA          880   UCUGGAGG AGAA GGUUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GGAACCU GUC CCUCCAGA          919   AAGGACAA AGAA GGAUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGAUCCU GCU UUGUCCUU          963   CUUUAAAG AGAA GGAUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AAAUCCU GAU CUUUAAAG          1360  UCUUCAAA AGAA GCAUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGAUGCU GUU UUUGAAGA          1407  CAAACUCC AGAA GUGAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CUUCACA GUU GGAGUUUG          1460  AUUAAGCC AGAA GUUACU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AGUAACA GCU GGCUUAAU          1570  ACAGCACA AGAA GGAGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UUCUCCU GCC UGUGCUGU          1667  AGCUAAGC AGAA GCCCAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AUGGGCU GCU GCUUAGCU          1670  GCAAGCUA AGAA GCAGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GGCUGCU GCU                   __________________________________________________________________________                                                    UAGCUUGC                  

                                      TABLE IX                                    __________________________________________________________________________    Rabbit Hairpin Ribozyme and Target Sequences                                  nt.                                                                           Position                                                                            Ribozyme Sequence                         Substrate                     __________________________________________________________________________    77    CCACGCAC AGAA GUAGCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGCUACU GCU GUGCGUGG          99    AGUGGAUA AGAA GAGCAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UUGCUCA GCC UAUCCACU          203   UUUUAACA AGAA GUUUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGAAACA GUU UGUUAAAA          231   UUUUUAAC AGAA GGACUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UAGUCCU GUU GUUAAAAA          339   UGACCAAC AGAA GGAACG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CGUUCCU GAU GUUGGUCA          423   CUUGGCAG AGAA GGUGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CACACCG GAU CUGCCAAG          441   GCAGCAUC AGAA GCAUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AGAUGCU GUU GAUGCUGC          702   AGCUCAUG AGAA GCAACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGUUGCU GCU CAUGAGCU          731   CCGAGUGA AGAA GACCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGGGUCU GUU UCACUCGG          758   CUGGGUAC AGAA GCGCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AAGCGCU GAU GUACCCAG          768   GCGUUGUA AGAA GGGUAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GUACCCA GUC UACAACGC          786   CGGGCCAG AGAA GUGAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CUUCACA GAC CUGGCCCG          797   AAAGGCGG AGAA GGGCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGGCCCG GUU CCGCCUUU          802   UUGAGAAA AGAA GAACCG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CGGUUCC GCC UUUCUCAA          849   GAGGCAGG AGAA GGUCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGGACCG GCC CCUGCCUC          855   UCAGGAGA AGAA GGGGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GGCCCCU GCC UCUCCUGA          891   CCUGGAGG AGAA GGUUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GGAACCU GUC CCUCCAGG          930   AAGGACAG AGAA GGAUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGAUCCA GAU CUGUCCUU          935   CAUCGAAG AGAA GAUCUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CAGAUCU GUC CUUCGAUG          974   CUUUAAAG AGAA GAAUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AAAUUCU GUU CUUUAAAG          1107  AAAAUGAA AGAA GUAUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GGAUACU GUU UUCAUUUU          1130  UGGCCCAG AGAA GAGUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GAACUCA GUU CUGGGCCA          1301  GCUCCAGG AGAA GUCUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AGAGACA GUC CCUGGAGC          1371  GCUUCAAA AGAA GCAUCG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CGAUGCU GUU UUUGAAGC          1418  CAAACUCC AGAA GUGAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               CUUCACA GUC GGAGUUUG          1471  CUGAAACC AGAA GUUGCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               AGCAACA GCU GGUUUCAG          1663  AGCUAAGC AGAA GCCUGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               ACAGGCU GCU GCUUAGCU          1666  GCAAGCUA AGAA GCAGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               GGCUGCU GCU UAGCUUGC          1733  AAUCACUC AGAA GUCACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                               UGUGACA GAC                   __________________________________________________________________________                                                    GAGUGAUU                  

    __________________________________________________________________________    SEQUENCE LISTING                                                              (1) GENERAL INFORMATION:                                                      (iii) NUMBER OF SEQUENCES: 1151                                               (2) INFORMATION FOR SEQ ID NO:1:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 19 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1:                                       UAGAGCUAAGUAAAGCCAG19                                                         (2) INFORMATION FOR SEQ ID NO:2:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 13 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2:                                       ACACCAGCAUGAA13                                                               (2) INFORMATION FOR SEQ ID NO:3:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 13 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3:                                       AGAAAUAUCUAGA13                                                               (2) INFORMATION FOR SEQ ID NO:4:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 24 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4:                                       ACCUCAAAAAAGAUGUGAAACAGU24                                                    (2) INFORMATION FOR SEQ ID NO:5:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 14 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5:                                       AAAUGCAGAAGUUC14                                                              (2) INFORMATION FOR SEQ ID NO:6:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 33 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6:                                       GACACUCUGGAGGUGAUGCGCAAGCCCAGGUGU33                                           (2) INFORMATION FOR SEQ ID NO:7:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 22 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7:                                       CUGAUGUUGGUCACUUCAGAAC22                                                      (2) INFORMATION FOR SEQ ID NO:8:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 33 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8:                                       GCAUCCCGAAGUGGAGGAAAACCCACCUUACAU33                                           (2) INFORMATION FOR SEQ ID NO:9:                                              (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 27 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9:                                       AUUAUACACCAGAUUUGCCAAAAGAUG27                                                 (2) INFORMATION FOR SEQ ID NO:10:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 21 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10:                                      CUGUUGAUUCUGCUGUUGAGA21                                                       (2) INFORMATION FOR SEQ ID NO:11:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 22 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11:                                      CUGAAAGUCUGGGAAGAGGUGA22                                                      (2) INFORMATION FOR SEQ ID NO:12:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 12 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12:                                      CUGAUAUAAUGA12                                                                (2) INFORMATION FOR SEQ ID NO:13:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 12 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13:                                      UGCCUAUGCCCC12                                                                (2) INFORMATION FOR SEQ ID NO:14:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 32 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14:                                      AUGCCCACUUUGAUGAUGAUGAACAAUGGACA32                                            (2) INFORMATION FOR SEQ ID NO:15:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 20 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15:                                      AUUUCUCGUUGCUGCUCAUG20                                                        (2) INFORMATION FOR SEQ ID NO:16:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16:                                      CACUCAGCCAACACUGA17                                                           (2) INFORMATION FOR SEQ ID NO:17:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 26 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17:                                      AAGAUGAUAUAAAUGGCAUUCAGUCC26                                                  (2) INFORMATION FOR SEQ ID NO:18:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 27 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18:                                      CUCUAUGGACCUCCCCCUGACUCCCCU27                                                 (2) INFORMATION FOR SEQ ID NO:19:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 14 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19:                                      CCCCCUGGUACCCA14                                                              (2) INFORMATION FOR SEQ ID NO:20:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 30 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20:                                      UCCUGCUUUGUCCUUUGAUGCUGUCAGCAC30                                              (2) INFORMATION FOR SEQ ID NO:21:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21:                                      AAUCCUGAUCUUUAAAGA18                                                          (2) INFORMATION FOR SEQ ID NO:22:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:                                      CAGGCACUUUUGGCGCAAAUCCC23                                                     (2) INFORMATION FOR SEQ ID NO:23:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 30 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23:                                      AUUGCAUUUGAUCUCUUCAUUUUGGCCAUC30                                              (2) INFORMATION FOR SEQ ID NO:24:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 13 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24:                                      GCAUAUGAAGUUA13                                                               (2) INFORMATION FOR SEQ ID NO:25:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 22 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25:                                      AAAUCGAUGCAGCCAUUUCUGA22                                                      (2) INFORMATION FOR SEQ ID NO:26:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 28 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26:                                      UUUGAUGAGAAGAGAAAUUCCAUGGAGC28                                                (2) INFORMATION FOR SEQ ID NO:27:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 29 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27:                                      CAGGCUUUCCCAAGCAAAUAGCUGAAGAC29                                               (2) INFORMATION FOR SEQ ID NO:28:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 13 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28:                                      CCCAAAUGCAAAG13                                                               (2) INFORMATION FOR SEQ ID NO:29:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 30 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29:                                      AUGUAGAAGGCACAAUAUGGGCACUUUAAA30                                              (2) INFORMATION FOR SEQ ID NO:30:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 24 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30:                                      UCUUGCCGGUCAUUUUUAUGUUAU24                                                    (2) INFORMATION FOR SEQ ID NO:31:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 13 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31:                                      GCUGCUGCUUAGC13                                                               (2) INFORMATION FOR SEQ ID NO:32:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 22 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32:                                      CAACAGACAAGUGACUGUAUCU22                                                      (2) INFORMATION FOR SEQ ID NO:33:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 11 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:                                      CUUAUUUAAUA11                                                                 (2) INFORMATION FOR SEQ ID NO:34:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 25 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34:                                      GCAAGGCAUAGAGACAACAUAGAGC25                                                   (2) INFORMATION FOR SEQ ID NO:35:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35:                                      GCAUAGAGACAACAUAGAGCUAAGUAAAGCC31                                             (2) INFORMATION FOR SEQ ID NO:36:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36:                                      AGACAACAUAGAGCUAAGUAAAGCCAGUGGA31                                             (2) INFORMATION FOR SEQ ID NO:37:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37:                                      AACAUAGAGCUAAGUAAAGCCAGUGGAAAUG31                                             (2) INFORMATION FOR SEQ ID NO:38:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38:                                      GUGGAAAUGAAGAGUCUUCCAAUCCUACUGU31                                             (2) INFORMATION FOR SEQ ID NO:39:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39:                                      GGAAAUGAAGAGUCUUCCAAUCCUACUGUUG31                                             (2) INFORMATION FOR SEQ ID NO:40:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40:                                      GAAAUGAAGAGUCUUCCAAUCCUACUGUUGC31                                             (2) INFORMATION FOR SEQ ID NO:41:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41:                                      GAAGAGUCUUCCAAUCCUACUGUUGCUGUGC31                                             (2) INFORMATION FOR SEQ ID NO:42:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42:                                      GAGUCUUCCAAUCCUACUGUUGCUGUGCGUG31                                             (2) INFORMATION FOR SEQ ID NO:43:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:                                      UUCCAAUCCUACUGUUGCUGUGCGUGGCAGU31                                             (2) INFORMATION FOR SEQ ID NO:44:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44:                                      GCUGUGCGUGGCAGUUUGCUCAGCCUAUCCA31                                             (2) INFORMATION FOR SEQ ID NO:45:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45:                                      CUGUGCGUGGCAGUUUGCUCAGCCUAUCCAU31                                             (2) INFORMATION FOR SEQ ID NO:46:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46:                                      GCGUGGCAGUUUGCUCAGCCUAUCCAUUGGA31                                             (2) INFORMATION FOR SEQ ID NO:47:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47:                                      CAGUUUGCUCAGCCUAUCCAUUGGAUGGAGC31                                             (2) INFORMATION FOR SEQ ID NO:48:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48:                                      GUUUGCUCAGCCUAUCCAUUGGAUGGAGCUG31                                             (2) INFORMATION FOR SEQ ID NO:49:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49:                                      GCUCAGCCUAUCCAUUGGAUGGAGCUGCAAG31                                             (2) INFORMATION FOR SEQ ID NO:50:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50:                                      CACCAGCAUGAACCUUGUUCAGAAAUAUCUA31                                             (2) INFORMATION FOR SEQ ID NO:51:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51:                                      CAGCAUGAACCUUGUUCAGAAAUAUCUAGAA31                                             (2) INFORMATION FOR SEQ ID NO:52:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52:                                      AGCAUGAACCUUGUUCAGAAAUAUCUAGAAA31                                             (2) INFORMATION FOR SEQ ID NO:53:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53:                                      ACCUUGUUCAGAAAUAUCUAGAAAACUACUA31                                             (2) INFORMATION FOR SEQ ID NO:54:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54:                                      CUUGUUCAGAAAUAUCUAGAAAACUACUACG31                                             (2) INFORMATION FOR SEQ ID NO:55:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:55:                                      UGUUCAGAAAUAUCUAGAAAACUACUACGAC31                                             (2) INFORMATION FOR SEQ ID NO:56:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56:                                      AAUAUCUAGAAAACUACUACGACCUCAAAAA31                                             (2) INFORMATION FOR SEQ ID NO:57:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57:                                      AUCUAGAAAACUACUACGACCUCAAAAAAGA31                                             (2) INFORMATION FOR SEQ ID NO:58:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58:                                      AAACUACUACGACCUCAAAAAAGAUGUGAAA31                                             (2) INFORMATION FOR SEQ ID NO:59:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59:                                      AAGAUGUGAAACAGUUUGUUAGGAGAAAGGA31                                             (2) INFORMATION FOR SEQ ID NO:60:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:60:                                      AGAUGUGAAACAGUUUGUUAGGAGAAAGGAC31                                             (2) INFORMATION FOR SEQ ID NO:61:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61:                                      UGUGAAACAGUUUGUUAGGAGAAAGGACAGU31                                             (2) INFORMATION FOR SEQ ID NO:62:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62:                                      GUGAAACAGUUUGUUAGGAGAAAGGACAGUG31                                             (2) INFORMATION FOR SEQ ID NO:63:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63:                                      AGAAAGGACAGUGGUCCUGUUGUUAAAAAAA31                                             (2) INFORMATION FOR SEQ ID NO:64:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64:                                      GGACAGUGGUCCUGUUGUUAAAAAAAUCCGA31                                             (2) INFORMATION FOR SEQ ID NO:65:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:65:                                      CAGUGGUCCUGUUGUUAAAAAAAUCCGAGAA31                                             (2) INFORMATION FOR SEQ ID NO:66:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66:                                      AGUGGUCCUGUUGUUAAAAAAAUCCGAGAAA31                                             (2) INFORMATION FOR SEQ ID NO:67:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67:                                      UGUUGUUAAAAAAAUCCGAGAAAUGCAGAAG31                                             (2) INFORMATION FOR SEQ ID NO:68:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68:                                      GAGAAAUGCAGAAGUUCCUUGGAUUGGAGGU31                                             (2) INFORMATION FOR SEQ ID NO:69:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69:                                      AGAAAUGCAGAAGUUCCUUGGAUUGGAGGUG31                                             (2) INFORMATION FOR SEQ ID NO:70:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:70:                                      AAUGCAGAAGUUCCUUGGAUUGGAGGUGACG31                                             (2) INFORMATION FOR SEQ ID NO:71:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:71:                                      AGAAGUUCCUUGGAUUGGAGGUGACGGGGAA31                                             (2) INFORMATION FOR SEQ ID NO:72:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:72:                                      CGGGGAAGCUGGACUCCGACACUCUGGAGGU31                                             (2) INFORMATION FOR SEQ ID NO:73:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73:                                      CUGGACUCCGACACUCUGGAGGUGAUGCGCA31                                             (2) INFORMATION FOR SEQ ID NO:74:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74:                                      GCCCAGGUGUGGAGUUCCUGAUGUUGGUCAC31                                             (2) INFORMATION FOR SEQ ID NO:75:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75:                                      CCCAGGUGUGGAGUUCCUGAUGUUGGUCACU31                                             (2) INFORMATION FOR SEQ ID NO:76:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:76:                                      UGGAGUUCCUGAUGUUGGUCACUUCAGAACC31                                             (2) INFORMATION FOR SEQ ID NO:77:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77:                                      GUUCCUGAUGUUGGUCACUUCAGAACCUUUC31                                             (2) INFORMATION FOR SEQ ID NO:78:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78:                                      CUGAUGUUGGUCACUUCAGAACCUUUCCUGG31                                             (2) INFORMATION FOR SEQ ID NO:79:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79:                                      UGAUGUUGGUCACUUCAGAACCUUUCCUGGC31                                             (2) INFORMATION FOR SEQ ID NO:80:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:80:                                      GUCACUUCAGAACCUUUCCUGGCAUCCCGAA31                                             (2) INFORMATION FOR SEQ ID NO:81:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81:                                      UCACUUCAGAACCUUUCCUGGCAUCCCGAAG31                                             (2) INFORMATION FOR SEQ ID NO:82:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82:                                      CACUUCAGAACCUUUCCUGGCAUCCCGAAGU31                                             (2) INFORMATION FOR SEQ ID NO:83:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83:                                      AACCUUUCCUGGCAUCCCGAAGUGGAGGAAA31                                             (2) INFORMATION FOR SEQ ID NO:84:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:84:                                      GAGGAAAACCCACCUUACAUACAGGAUUGUG31                                             (2) INFORMATION FOR SEQ ID NO:85:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:85:                                      AGGAAAACCCACCUUACAUACAGGAUUGUGA31                                             (2) INFORMATION FOR SEQ ID NO:86:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86:                                      AAACCCACCUUACAUACAGGAUUGUGAAUUA31                                             (2) INFORMATION FOR SEQ ID NO:87:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87:                                      CCUUACAUACAGGAUUGUGAAUUAUACACCA31                                             (2) INFORMATION FOR SEQ ID NO:88:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88:                                      UACAGGAUUGUGAAUUAUACACCAGAUUUGC31                                             (2) INFORMATION FOR SEQ ID NO:89:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89:                                      ACAGGAUUGUGAAUUAUACACCAGAUUUGCC31                                             (2) INFORMATION FOR SEQ ID NO:90:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:90:                                      AGGAUUGUGAAUUAUACACCAGAUUUGCCAA31                                             (2) INFORMATION FOR SEQ ID NO:91:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:91:                                      AAUUAUACACCAGAUUUGCCAAAAGAUGCUG31                                             (2) INFORMATION FOR SEQ ID NO:92:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92:                                      AUUAUACACCAGAUUUGCCAAAAGAUGCUGU31                                             (2) INFORMATION FOR SEQ ID NO:93:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93:                                      GCCAAAAGAUGCUGUUGAUUCUGCUGUUGAG31                                             (2) INFORMATION FOR SEQ ID NO:94:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94:                                      AAAGAUGCUGUUGAUUCUGCUGUUGAGAAAG31                                             (2) INFORMATION FOR SEQ ID NO:95:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:95:                                      AAGAUGCUGUUGAUUCUGCUGUUGAGAAAGC31                                             (2) INFORMATION FOR SEQ ID NO:96:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96:                                      UGUUGAUUCUGCUGUUGAGAAAGCUCUGAAA31                                             (2) INFORMATION FOR SEQ ID NO:97:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97:                                      GCUGUUGAGAAAGCUCUGAAAGUCUGGGAAG31                                             (2) INFORMATION FOR SEQ ID NO:98:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98:                                      GAAAGCUCUGAAAGUCUGGGAAGAGGUGACU31                                             (2) INFORMATION FOR SEQ ID NO:99:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99:                                      UGGGAAGAGGUGACUCCACUCACAUUCUCCA31                                             (2) INFORMATION FOR SEQ ID NO:100:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100:                                     AGAGGUGACUCCACUCACAUUCUCCAGGCUG31                                             (2) INFORMATION FOR SEQ ID NO:101:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:101:                                     UGACUCCACUCACAUUCUCCAGGCUGUAUGA31                                             (2) INFORMATION FOR SEQ ID NO:102:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102:                                     GACUCCACUCACAUUCUCCAGGCUGUAUGAA31                                             (2) INFORMATION FOR SEQ ID NO:103:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103:                                     CUCCACUCACAUUCUCCAGGCUGUAUGAAGG31                                             (2) INFORMATION FOR SEQ ID NO:104:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104:                                     CAUUCUCCAGGCUGUAUGAAGGAGAGGCUGA31                                             (2) INFORMATION FOR SEQ ID NO:105:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105:                                     GAAGGAGAGGCUGAUAUAAUGAUCUCUUUUG31                                             (2) INFORMATION FOR SEQ ID NO:106:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106:                                     AGGAGAGGCUGAUAUAAUGAUCUCUUUUGCA31                                             (2) INFORMATION FOR SEQ ID NO:107:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107:                                     GGCUGAUAUAAUGAUCUCUUUUGCAGUUAGA31                                             (2) INFORMATION FOR SEQ ID NO:108:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108:                                     CUGAUAUAAUGAUCUCUUUUGCAGUUAGAGA31                                             (2) INFORMATION FOR SEQ ID NO:109:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109:                                     GAUAUAAUGAUCUCUUUUGCAGUUAGAGAAC31                                             (2) INFORMATION FOR SEQ ID NO:110:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:110:                                     AUAUAAUGAUCUCUUUUGCAGUUAGAGAACA31                                             (2) INFORMATION FOR SEQ ID NO:111:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:111:                                     UAUAAUGAUCUCUUUUGCAGUUAGAGAACAU31                                             (2) INFORMATION FOR SEQ ID NO:112:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:112:                                     GAUCUCUUUUGCAGUUAGAGAACAUGGAGAC31                                             (2) INFORMATION FOR SEQ ID NO:113:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113:                                     AUCUCUUUUGCAGUUAGAGAACAUGGAGACU31                                             (2) INFORMATION FOR SEQ ID NO:114:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:114:                                     GAGAACAUGGAGACUUUUACCCUUUUGAUGG31                                             (2) INFORMATION FOR SEQ ID NO:115:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115:                                     AGAACAUGGAGACUUUUACCCUUUUGAUGGA31                                             (2) INFORMATION FOR SEQ ID NO:116:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116:                                     GAACAUGGAGACUUUUACCCUUUUGAUGGAC31                                             (2) INFORMATION FOR SEQ ID NO:117:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117:                                     AACAUGGAGACUUUUACCCUUUUGAUGGACC31                                             (2) INFORMATION FOR SEQ ID NO:118:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:118:                                     GGAGACUUUUACCCUUUUGAUGGACCUGGAA31                                             (2) INFORMATION FOR SEQ ID NO:119:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:119:                                     GAGACUUUUACCCUUUUGAUGGACCUGGAAA31                                             (2) INFORMATION FOR SEQ ID NO:120:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:120:                                     AGACUUUUACCCUUUUGAUGGACCUGGAAAU31                                             (2) INFORMATION FOR SEQ ID NO:121:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121:                                     UGGACCUGGAAAUGUUUUGGCCCAUGCCUAU31                                             (2) INFORMATION FOR SEQ ID NO:122:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:122:                                     GGACCUGGAAAUGUUUUGGCCCAUGCCUAUG31                                             (2) INFORMATION FOR SEQ ID NO:123:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123:                                     GACCUGGAAAUGUUUUGGCCCAUGCCUAUGC31                                             (2) INFORMATION FOR SEQ ID NO:124:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:124:                                     UUUUGGCCCAUGCCUAUGCCCCUGGGCCAGG31                                             (2) INFORMATION FOR SEQ ID NO:125:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125:                                     CCCUGGGCCAGGGAUUAAUGGAGAUGCCCAC31                                             (2) INFORMATION FOR SEQ ID NO:126:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:126:                                     CCUGGGCCAGGGAUUAAUGGAGAUGCCCACU31                                             (2) INFORMATION FOR SEQ ID NO:127:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:127:                                     AUGGAGAUGCCCACUUUGAUGAUGAUGAACA31                                             (2) INFORMATION FOR SEQ ID NO:128:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:128:                                     UGGAGAUGCCCACUUUGAUGAUGAUGAACAA31                                             (2) INFORMATION FOR SEQ ID NO:129:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129:                                     CAAUGGACAAAGGAUACAACAGGGACCAAUU31                                             (2) INFORMATION FOR SEQ ID NO:130:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:130:                                     ACAACAGGGACCAAUUUAUUUCUCGUUGCUG31                                             (2) INFORMATION FOR SEQ ID NO:131:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:131:                                     CAACAGGGACCAAUUUAUUUCUCGUUGCUGC31                                             (2) INFORMATION FOR SEQ ID NO:132:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132:                                     AACAGGGACCAAUUUAUUUCUCGUUGCUGCU31                                             (2) INFORMATION FOR SEQ ID NO:133:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:133:                                     CAGGGACCAAUUUAUUUCUCGUUGCUGCUCA31                                             (2) INFORMATION FOR SEQ ID NO:134:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134:                                     AGGGACCAAUUUAUUUCUCGUUGCUGCUCAU31                                             (2) INFORMATION FOR SEQ ID NO:135:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135:                                     GGGACCAAUUUAUUUCUCGUUGCUGCUCAUG31                                             (2) INFORMATION FOR SEQ ID NO:136:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136:                                     GACCAAUUUAUUUCUCGUUGCUGCUCAUGAA31                                             (2) INFORMATION FOR SEQ ID NO:137:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:137:                                     CAAUUUAUUUCUCGUUGCUGCUCAUGAAAUU31                                             (2) INFORMATION FOR SEQ ID NO:138:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:138:                                     UUUCUCGUUGCUGCUCAUGAAAUUGGCCACU31                                             (2) INFORMATION FOR SEQ ID NO:139:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139:                                     UGCUGCUCAUGAAAUUGGCCACUCCCUGGGU31                                             (2) INFORMATION FOR SEQ ID NO:140:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:140:                                     AUGAAAUUGGCCACUCCCUGGGUCUCUUUCA31                                             (2) INFORMATION FOR SEQ ID NO:141:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141:                                     GGCCACUCCCUGGGUCUCUUUCACUCAGCCA31                                             (2) INFORMATION FOR SEQ ID NO:142:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:142:                                     CCACUCCCUGGGUCUCUUUCACUCAGCCAAC31                                             (2) INFORMATION FOR SEQ ID NO:143:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:143:                                     ACUCCCUGGGUCUCUUUCACUCAGCCAACAC31                                             (2) INFORMATION FOR SEQ ID NO:144:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144:                                     CUCCCUGGGUCUCUUUCACUCAGCCAACACU31                                             (2) INFORMATION FOR SEQ ID NO:145:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:145:                                     UCCCUGGGUCUCUUUCACUCAGCCAACACUG31                                             (2) INFORMATION FOR SEQ ID NO:146:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:146:                                     UGGGUCUCUUUCACUCAGCCAACACUGAAGC31                                             (2) INFORMATION FOR SEQ ID NO:147:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147:                                     GCCAACACUGAAGCUUUGAUGUACCCACUCU31                                             (2) INFORMATION FOR SEQ ID NO:148:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148:                                     CCAACACUGAAGCUUUGAUGUACCCACUCUA31                                             (2) INFORMATION FOR SEQ ID NO:149:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:149:                                     CUGAAGCUUUGAUGUACCCACUCUAUCACUC31                                             (2) INFORMATION FOR SEQ ID NO:150:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:150:                                     UUUGAUGUACCCACUCUAUCACUCACUCACA31                                             (2) INFORMATION FOR SEQ ID NO:151:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:151:                                     UGAUGUACCCACUCUAUCACUCACUCACAGA31                                             (2) INFORMATION FOR SEQ ID NO:152:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:152:                                     AUGUACCCACUCUAUCACUCACUCACAGACC31                                             (2) INFORMATION FOR SEQ ID NO:153:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:153:                                     ACCCACUCUAUCACUCACUCACAGACCUGAC31                                             (2) INFORMATION FOR SEQ ID NO:154:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:154:                                     ACUCUAUCACUCACUCACAGACCUGACUCGG31                                             (2) INFORMATION FOR SEQ ID NO:155:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:155:                                     CUCACAGACCUGACUCGGUUCCGCCUGUCUC31                                             (2) INFORMATION FOR SEQ ID NO:156:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156:                                     CAGACCUGACUCGGUUCCGCCUGUCUCAAGA31                                             (2) INFORMATION FOR SEQ ID NO:157:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:157:                                     AGACCUGACUCGGUUCCGCCUGUCUCAAGAU31                                             (2) INFORMATION FOR SEQ ID NO:158:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:158:                                     CUCGGUUCCGCCUGUCUCAAGAUGAUAUAAA31                                             (2) INFORMATION FOR SEQ ID NO:159:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159:                                     CGGUUCCGCCUGUCUCAAGAUGAUAUAAAUG31                                             (2) INFORMATION FOR SEQ ID NO:160:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160:                                     CUGUCUCAAGAUGAUAUAAAUGGCAUUCAGU31                                             (2) INFORMATION FOR SEQ ID NO:161:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:161:                                     GUCUCAAGAUGAUAUAAAUGGCAUUCAGUCC31                                             (2) INFORMATION FOR SEQ ID NO:162:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162:                                     UGAUAUAAAUGGCAUUCAGUCCCUCUAUGGA31                                             (2) INFORMATION FOR SEQ ID NO:163:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163:                                     GAUAUAAAUGGCAUUCAGUCCCUCUAUGGAC31                                             (2) INFORMATION FOR SEQ ID NO:164:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:164:                                     UAAAUGGCAUUCAGUCCCUCUAUGGACCUCC31                                             (2) INFORMATION FOR SEQ ID NO:165:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:165:                                     UGGCAUUCAGUCCCUCUAUGGACCUCCCCCU31                                             (2) INFORMATION FOR SEQ ID NO:166:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:166:                                     GCAUUCAGUCCCUCUAUGGACCUCCCCCUGA31                                             (2) INFORMATION FOR SEQ ID NO:167:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:167:                                     UCCCUCUAUGGACCUCCCCCUGACUCCCCUG31                                             (2) INFORMATION FOR SEQ ID NO:168:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:168:                                     GACCUCCCCCUGACUCCCCUGAGACCCCCCU31                                             (2) INFORMATION FOR SEQ ID NO:169:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:169:                                     UGAGACCCCCCUGGUACCCACGGAACCUGUC31                                             (2) INFORMATION FOR SEQ ID NO:170:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:170:                                     ACCCACGGAACCUGUCCCUCCAGAACCUGGG31                                             (2) INFORMATION FOR SEQ ID NO:171:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:171:                                     ACGGAACCUGUCCCUCCAGAACCUGGGACGC31                                             (2) INFORMATION FOR SEQ ID NO:172:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:172:                                     CCAGCCAACUGUGAUCCUGCUUUGUCCUUUG31                                             (2) INFORMATION FOR SEQ ID NO:173:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173:                                     AACUGUGAUCCUGCUUUGUCCUUUGAUGCUG31                                             (2) INFORMATION FOR SEQ ID NO:174:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:174:                                     ACUGUGAUCCUGCUUUGUCCUUUGAUGCUGU31                                             (2) INFORMATION FOR SEQ ID NO:175:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:175:                                     GUGAUCCUGCUUUGUCCUUUGAUGCUGUCAG31                                             (2) INFORMATION FOR SEQ ID NO:176:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:176:                                     AUCCUGCUUUGUCCUUUGAUGCUGUCAGCAC31                                             (2) INFORMATION FOR SEQ ID NO:177:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177:                                     UCCUGCUUUGUCCUUUGAUGCUGUCAGCACU31                                             (2) INFORMATION FOR SEQ ID NO:178:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:178:                                     GUCCUUUGAUGCUGUCAGCACUCUGAGGGGA31                                             (2) INFORMATION FOR SEQ ID NO:179:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179:                                     GAUGCUGUCAGCACUCUGAGGGGAGAAAUCC31                                             (2) INFORMATION FOR SEQ ID NO:180:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:180:                                     UCUGAGGGGAGAAAUCCUGAUCUUUAAAGAC31                                             (2) INFORMATION FOR SEQ ID NO:181:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:181:                                     GGGAGAAAUCCUGAUCUUUAAAGACAGGCAC31                                             (2) INFORMATION FOR SEQ ID NO:182:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182:                                     GAGAAAUCCUGAUCUUUAAAGACAGGCACUU31                                             (2) INFORMATION FOR SEQ ID NO:183:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183:                                     AGAAAUCCUGAUCUUUAAAGACAGGCACUUU31                                             (2) INFORMATION FOR SEQ ID NO:184:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184:                                     GAAAUCCUGAUCUUUAAAGACAGGCACUUUU31                                             (2) INFORMATION FOR SEQ ID NO:185:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:185:                                     UUAAAGACAGGCACUUUUGGCGCAAAUCCCU31                                             (2) INFORMATION FOR SEQ ID NO:186:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:186:                                     UAAAGACAGGCACUUUUGGCGCAAAUCCCUC31                                             (2) INFORMATION FOR SEQ ID NO:187:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:187:                                     AAAGACAGGCACUUUUGGCGCAAAUCCCUCA31                                             (2) INFORMATION FOR SEQ ID NO:188:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188:                                     ACUUUUGGCGCAAAUCCCUCAGGAAGCUUGA31                                             (2) INFORMATION FOR SEQ ID NO:189:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:189:                                     UUGGCGCAAAUCCCUCAGGAAGCUUGAACCU31                                             (2) INFORMATION FOR SEQ ID NO:190:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190:                                     AUCCCUCAGGAAGCUUGAACCUGAAUUGCAU31                                             (2) INFORMATION FOR SEQ ID NO:191:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:191:                                     AGCUUGAACCUGAAUUGCAUUUGAUCUCUUC31                                             (2) INFORMATION FOR SEQ ID NO:192:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:192:                                     GAACCUGAAUUGCAUUUGAUCUCUUCAUUUU31                                             (2) INFORMATION FOR SEQ ID NO:193:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:193:                                     AACCUGAAUUGCAUUUGAUCUCUUCAUUUUG31                                             (2) INFORMATION FOR SEQ ID NO:194:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194:                                     UGAAUUGCAUUUGAUCUCUUCAUUUUGGCCA31                                             (2) INFORMATION FOR SEQ ID NO:195:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:195:                                     AAUUGCAUUUGAUCUCUUCAUUUUGGCCAUC31                                             (2) INFORMATION FOR SEQ ID NO:196:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:196:                                     UUGCAUUUGAUCUCUUCAUUUUGGCCAUCUC31                                             (2) INFORMATION FOR SEQ ID NO:197:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:197:                                     UGCAUUUGAUCUCUUCAUUUUGGCCAUCUCU31                                             (2) INFORMATION FOR SEQ ID NO:198:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:198:                                     AUUUGAUCUCUUCAUUUUGGCCAUCUCUUCC31                                             (2) INFORMATION FOR SEQ ID NO:199:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:199:                                     UUUGAUCUCUUCAUUUUGGCCAUCUCUUCCU31                                             (2) INFORMATION FOR SEQ ID NO:200:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:200:                                     UUGAUCUCUUCAUUUUGGCCAUCUCUUCCUU31                                             (2) INFORMATION FOR SEQ ID NO:201:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:201:                                     CUUCAUUUUGGCCAUCUCUUCCUUCAGGCGU31                                             (2) INFORMATION FOR SEQ ID NO:202:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:202:                                     UCAUUUUGGCCAUCUCUUCCUUCAGGCGUGG31                                             (2) INFORMATION FOR SEQ ID NO:203:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:203:                                     AUUUUGGCCAUCUCUUCCUUCAGGCGUGGAU31                                             (2) INFORMATION FOR SEQ ID NO:204:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:204:                                     UUUUGGCCAUCUCUUCCUUCAGGCGUGGAUG31                                             (2) INFORMATION FOR SEQ ID NO:205:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:205:                                     UGGCCAUCUCUUCCUUCAGGCGUGGAUGCCG31                                             (2) INFORMATION FOR SEQ ID NO:206:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:206:                                     GGCCAUCUCUUCCUUCAGGCGUGGAUGCCGC31                                             (2) INFORMATION FOR SEQ ID NO:207:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207:                                     GCGUGGAUGCCGCAUAUGAAGUUACUAGCAA31                                             (2) INFORMATION FOR SEQ ID NO:208:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:208:                                     UGCCGCAUAUGAAGUUACUAGCAAGGACCUC31                                             (2) INFORMATION FOR SEQ ID NO:209:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:209:                                     GCCGCAUAUGAAGUUACUAGCAAGGACCUCG31                                             (2) INFORMATION FOR SEQ ID NO:210:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:210:                                     GCAUAUGAAGUUACUAGCAAGGACCUCGUUU31                                             (2) INFORMATION FOR SEQ ID NO:211:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:211:                                     UACUAGCAAGGACCUCGUUUUCAUUUUUAAA31                                             (2) INFORMATION FOR SEQ ID NO:212:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:212:                                     UAGCAAGGACCUCGUUUUCAUUUUUAAAGGA31                                             (2) INFORMATION FOR SEQ ID NO:213:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:213:                                     AGCAAGGACCUCGUUUUCAUUUUUAAAGGAA31                                             (2) INFORMATION FOR SEQ ID NO:214:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:214:                                     GCAAGGACCUCGUUUUCAUUUUUAAAGGAAA31                                             (2) INFORMATION FOR SEQ ID NO:215:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:215:                                     CAAGGACCUCGUUUUCAUUUUUAAAGGAAAU31                                             (2) INFORMATION FOR SEQ ID NO:216:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:216:                                     GGACCUCGUUUUCAUUUUUAAAGGAAAUCAA31                                             (2) INFORMATION FOR SEQ ID NO:217:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:217:                                     GACCUCGUUUUCAUUUUUAAAGGAAAUCAAU31                                             (2) INFORMATION FOR SEQ ID NO:218:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:218:                                     ACCUCGUUUUCAUUUUUAAAGGAAAUCAAUU31                                             (2) INFORMATION FOR SEQ ID NO:219:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:219:                                     CCUCGUUUUCAUUUUUAAAGGAAAUCAAUUC31                                             (2) INFORMATION FOR SEQ ID NO:220:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:220:                                     CUCGUUUUCAUUUUUAAAGGAAAUCAAUUCU31                                             (2) INFORMATION FOR SEQ ID NO:221:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:221:                                     AUUUUUAAAGGAAAUCAAUUCUGGGCCAUCA31                                             (2) INFORMATION FOR SEQ ID NO:222:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222:                                     UUAAAGGAAAUCAAUUCUGGGCCAUCAGAGG31                                             (2) INFORMATION FOR SEQ ID NO:223:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:223:                                     UAAAGGAAAUCAAUUCUGGGCCAUCAGAGGA31                                             (2) INFORMATION FOR SEQ ID NO:224:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:224:                                     UCAAUUCUGGGCCAUCAGAGGAAAUGAGGUA31                                             (2) INFORMATION FOR SEQ ID NO:225:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:225:                                     CAGAGGAAAUGAGGUACGAGCUGGAUACCCA31                                             (2) INFORMATION FOR SEQ ID NO:226:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:226:                                     AGGUACGAGCUGGAUACCCAAGAGGCAUCCA31                                             (2) INFORMATION FOR SEQ ID NO:227:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:227:                                     AUACCCAAGAGGCAUCCACACCCUAGGUUUC31                                             (2) INFORMATION FOR SEQ ID NO:228:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:228:                                     AGGCAUCCACACCCUAGGUUUCCCUCCAACC31                                             (2) INFORMATION FOR SEQ ID NO:229:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:229:                                     AUCCACACCCUAGGUUUCCCUCCAACCGUGA31                                             (2) INFORMATION FOR SEQ ID NO:230:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:230:                                     UCCACACCCUAGGUUUCCCUCCAACCGUGAG31                                             (2) INFORMATION FOR SEQ ID NO:231:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:231:                                     CCACACCCUAGGUUUCCCUCCAACCGUGAGG31                                             (2) INFORMATION FOR SEQ ID NO:232:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:232:                                     ACCCUAGGUUUCCCUCCAACCGUGAGGAAAA31                                             (2) INFORMATION FOR SEQ ID NO:233:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233:                                     AACCGUGAGGAAAAUCGAUGCAGCCAUUUCU31                                             (2) INFORMATION FOR SEQ ID NO:234:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:234:                                     AAUCGAUGCAGCCAUUUCUGAUAAGGAAAAG31                                             (2) INFORMATION FOR SEQ ID NO:235:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:235:                                     AUCGAUGCAGCCAUUUCUGAUAAGGAAAAGA31                                             (2) INFORMATION FOR SEQ ID NO:236:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:236:                                     UCGAUGCAGCCAUUUCUGAUAAGGAAAAGAA31                                             (2) INFORMATION FOR SEQ ID NO:237:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:237:                                     GCAGCCAUUUCUGAUAAGGAAAAGAACAAAA31                                             (2) INFORMATION FOR SEQ ID NO:238:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:238:                                     AAAAGAACAAAACAUAUUUCUUUGUAGAGGA31                                             (2) INFORMATION FOR SEQ ID NO:239:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:239:                                     AAGAACAAAACAUAUUUCUUUGUAGAGGACA31                                             (2) INFORMATION FOR SEQ ID NO:240:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:240:                                     AGAACAAAACAUAUUUCUUUGUAGAGGACAA31                                             (2) INFORMATION FOR SEQ ID NO:241:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:241:                                     GAACAAAACAUAUUUCUUUGUAGAGGACAAA31                                             (2) INFORMATION FOR SEQ ID NO:242:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:242:                                     ACAAAACAUAUUUCUUUGUAGAGGACAAAUA31                                             (2) INFORMATION FOR SEQ ID NO:243:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:243:                                     CAAAACAUAUUUCUUUGUAGAGGACAAAUAC31                                             (2) INFORMATION FOR SEQ ID NO:244:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:244:                                     AACAUAUUUCUUUGUAGAGGACAAAUACUGG31                                             (2) INFORMATION FOR SEQ ID NO:245:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:245:                                     UUGUAGAGGACAAAUACUGGAGAUUUGAUGA31                                             (2) INFORMATION FOR SEQ ID NO:246:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:246:                                     ACAAAUACUGGAGAUUUGAUGAGAAGAGAAA31                                             (2) INFORMATION FOR SEQ ID NO:247:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:247:                                     CAAAUACUGGAGAUUUGAUGAGAAGAGAAAU31                                             (2) INFORMATION FOR SEQ ID NO:248:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:248:                                     GAUGAGAAGAGAAAUUCCAUGGAGCCAGGCU31                                             (2) INFORMATION FOR SEQ ID NO:249:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:249:                                     AUGAGAAGAGAAAUUCCAUGGAGCCAGGCUU31                                             (2) INFORMATION FOR SEQ ID NO:250:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:250:                                     CCAUGGAGCCAGGCUUUCCCAAGCAAAUAGC31                                             (2) INFORMATION FOR SEQ ID NO:251:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:251:                                     CAUGGAGCCAGGCUUUCCCAAGCAAAUAGCU31                                             (2) INFORMATION FOR SEQ ID NO:252:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:252:                                     AUGGAGCCAGGCUUUCCCAAGCAAAUAGCUG31                                             (2) INFORMATION FOR SEQ ID NO:253:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:253:                                     CUUUCCCAAGCAAAUAGCUGAAGACUUUCCA31                                             (2) INFORMATION FOR SEQ ID NO:254:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:254:                                     AAAUAGCUGAAGACUUUCCAGGGAUUGACUC31                                             (2) INFORMATION FOR SEQ ID NO:255:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:255:                                     AAUAGCUGAAGACUUUCCAGGGAUUGACUCA31                                             (2) INFORMATION FOR SEQ ID NO:256:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:256:                                     AUAGCUGAAGACUUUCCAGGGAUUGACUCAA31                                             (2) INFORMATION FOR SEQ ID NO:257:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:257:                                     AGACUUUCCAGGGAUUGACUCAAAGAUUGAU31                                             (2) INFORMATION FOR SEQ ID NO:258:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:258:                                     UUCCAGGGAUUGACUCAAAGAUUGAUGCUGU31                                             (2) INFORMATION FOR SEQ ID NO:259:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:259:                                     GAUUGACUCAAAGAUUGAUGCUGUUUUUGAA31                                             (2) INFORMATION FOR SEQ ID NO:260:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:260:                                     AAAGAUUGAUGCUGUUUUUGAAGAAUUUGGG31                                             (2) INFORMATION FOR SEQ ID NO:261:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:261:                                     AAGAUUGAUGCUGUUUUUGAAGAAUUUGGGU31                                             (2) INFORMATION FOR SEQ ID NO:262:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:262:                                     AGAUUGAUGCUGUUUUUGAAGAAUUUGGGUU31                                             (2) INFORMATION FOR SEQ ID NO:263:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:263:                                     GAUUGAUGCUGUUUUUGAAGAAUUUGGGUUC31                                             (2) INFORMATION FOR SEQ ID NO:264:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:264:                                     CUGUUUUUGAAGAAUUUGGGUUCUUUUAUUU31                                             (2) INFORMATION FOR SEQ ID NO:265:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:265:                                     UGUUUUUGAAGAAUUUGGGUUCUUUUAUUUC31                                             (2) INFORMATION FOR SEQ ID NO:266:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:266:                                     UUGAAGAAUUUGGGUUCUUUUAUUUCUUUAC31                                             (2) INFORMATION FOR SEQ ID NO:267:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:267:                                     UGAAGAAUUUGGGUUCUUUUAUUUCUUUACU31                                             (2) INFORMATION FOR SEQ ID NO:268:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:268:                                     AAGAAUUUGGGUUCUUUUAUUUCUUUACUGG31                                             (2) INFORMATION FOR SEQ ID NO:269:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:269:                                     AGAAUUUGGGUUCUUUUAUUUCUUUACUGGA31                                             (2) INFORMATION FOR SEQ ID NO:270:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:270:                                     GAAUUUGGGUUCUUUUAUUUCUUUACUGGAU31                                             (2) INFORMATION FOR SEQ ID NO:271:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:271:                                     AAUUUGGGUUCUUUUAUUUCUUUACUGGAUC31                                             (2) INFORMATION FOR SEQ ID NO:272:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:272:                                     UUUGGGUUCUUUUAUUUCUUUACUGGAUCUU31                                             (2) INFORMATION FOR SEQ ID NO:273:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:273:                                     UUGGGUUCUUUUAUUUCUUUACUGGAUCUUC31                                             (2) INFORMATION FOR SEQ ID NO:274:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:274:                                     UGGGUUCUUUUAUUUCUUUACUGGAUCUUCA31                                             (2) INFORMATION FOR SEQ ID NO:275:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:275:                                     GGUUCUUUUAUUUCUUUACUGGAUCUUCACA31                                             (2) INFORMATION FOR SEQ ID NO:276:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:276:                                     GUUCUUUUAUUUCUUUACUGGAUCUUCACAG31                                             (2) INFORMATION FOR SEQ ID NO:277:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:277:                                     UUCUUUUAUUUCUUUACUGGAUCUUCACAGU31                                             (2) INFORMATION FOR SEQ ID NO:278:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:278:                                     AUUUCUUUACUGGAUCUUCACAGUUGGAGUU31                                             (2) INFORMATION FOR SEQ ID NO:279:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:279:                                     UUCUUUACUGGAUCUUCACAGUUGGAGUUUG31                                             (2) INFORMATION FOR SEQ ID NO:280:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:280:                                     UCUUUACUGGAUCUUCACAGUUGGAGUUUGA31                                             (2) INFORMATION FOR SEQ ID NO:281:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:281:                                     CUGGAUCUUCACAGUUGGAGUUUGACCCAAA31                                             (2) INFORMATION FOR SEQ ID NO:282:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:282:                                     CUUCACAGUUGGAGUUUGACCCAAAUGCAAA31                                             (2) INFORMATION FOR SEQ ID NO:283:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:283:                                     UUCACAGUUGGAGUUUGACCCAAAUGCAAAG31                                             (2) INFORMATION FOR SEQ ID NO:284:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:284:                                     AAAGUGACACACACUUUGAAGAGUAACAGCU31                                             (2) INFORMATION FOR SEQ ID NO:285:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:285:                                     AAGUGACACACACUUUGAAGAGUAACAGCUG31                                             (2) INFORMATION FOR SEQ ID NO:286:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:286:                                     CACACUUUGAAGAGUAACAGCUGGCUUAAUU31                                             (2) INFORMATION FOR SEQ ID NO:287:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:287:                                     GAGUAACAGCUGGCUUAAUUGUUGAAAGAGA31                                             (2) INFORMATION FOR SEQ ID NO:288:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:288:                                     AGUAACAGCUGGCUUAAUUGUUGAAAGAGAU31                                             (2) INFORMATION FOR SEQ ID NO:289:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:289:                                     AACAGCUGGCUUAAUUGUUGAAAGAGAUAUG31                                             (2) INFORMATION FOR SEQ ID NO:290:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:290:                                     AGCUGGCUUAAUUGUUGAAAGAGAUAUGUAG31                                             (2) INFORMATION FOR SEQ ID NO:291:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:291:                                     AUUGUUGAAAGAGAUAUGUAGAAGGCACAAU31                                             (2) INFORMATION FOR SEQ ID NO:292:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:292:                                     UUGAAAGAGAUAUGUAGAAGGCACAAUAUGG31                                             (2) INFORMATION FOR SEQ ID NO:293:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:293:                                     UGUAGAAGGCACAAUAUGGGCACUUUAAAUG31                                             (2) INFORMATION FOR SEQ ID NO:294:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:294:                                     CACAAUAUGGGCACUUUAAAUGAAGCUAAUA31                                             (2) INFORMATION FOR SEQ ID NO:295:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:295:                                     ACAAUAUGGGCACUUUAAAUGAAGCUAAUAA31                                             (2) INFORMATION FOR SEQ ID NO:296:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:296:                                     CAAUAUGGGCACUUUAAAUGAAGCUAAUAAU31                                             (2) INFORMATION FOR SEQ ID NO:297:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:297:                                     ACUUUAAAUGAAGCUAAUAAUUCUUCACCUA31                                             (2) INFORMATION FOR SEQ ID NO:298:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:298:                                     UUAAAUGAAGCUAAUAAUUCUUCACCUAAGU31                                             (2) INFORMATION FOR SEQ ID NO:299:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:299:                                     AAUGAAGCUAAUAAUUCUUCACCUAAGUCUC31                                             (2) INFORMATION FOR SEQ ID NO:300:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:300:                                     AUGAAGCUAAUAAUUCUUCACCUAAGUCUCU31                                             (2) INFORMATION FOR SEQ ID NO:301:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:301:                                     GAAGCUAAUAAUUCUUCACCUAAGUCUCUGU31                                             (2) INFORMATION FOR SEQ ID NO:302:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:302:                                     AAGCUAAUAAUUCUUCACCUAAGUCUCUGUG31                                             (2) INFORMATION FOR SEQ ID NO:303:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:303:                                     AAUAAUUCUUCACCUAAGUCUCUGUGAAUUG31                                             (2) INFORMATION FOR SEQ ID NO:304:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:304:                                     AUUCUUCACCUAAGUCUCUGUGAAUUGAAAU31                                             (2) INFORMATION FOR SEQ ID NO:305:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:305:                                     UCUUCACCUAAGUCUCUGUGAAUUGAAAUGU31                                             (2) INFORMATION FOR SEQ ID NO:306:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:306:                                     UAAGUCUCUGUGAAUUGAAAUGUUCGUUUUC31                                             (2) INFORMATION FOR SEQ ID NO:307:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:307:                                     UGUGAAUUGAAAUGUUCGUUUUCUCCUGCCU31                                             (2) INFORMATION FOR SEQ ID NO:308:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:308:                                     GUGAAUUGAAAUGUUCGUUUUCUCCUGCCUG31                                             (2) INFORMATION FOR SEQ ID NO:309:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:309:                                     AAUUGAAAUGUUCGUUUUCUCCUGCCUGUGC31                                             (2) INFORMATION FOR SEQ ID NO:310:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:310:                                     AUUGAAAUGUUCGUUUUCUCCUGCCUGUGCU31                                             (2) INFORMATION FOR SEQ ID NO:311:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:311:                                     UUGAAAUGUUCGUUUUCUCCUGCCUGUGCUG31                                             (2) INFORMATION FOR SEQ ID NO:312:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:312:                                     UGAAAUGUUCGUUUUCUCCUGCCUGUGCUGU31                                             (2) INFORMATION FOR SEQ ID NO:313:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:313:                                     AAAUGUUCGUUUUCUCCUGCCUGUGCUGUGA31                                             (2) INFORMATION FOR SEQ ID NO:314:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:314:                                     GCCUGUGCUGUGACUCGAGUCACACUCAAGG31                                             (2) INFORMATION FOR SEQ ID NO:315:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:315:                                     UGCUGUGACUCGAGUCACACUCAAGGGAACU31                                             (2) INFORMATION FOR SEQ ID NO:316:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:316:                                     GACUCGAGUCACACUCAAGGGAACUUGAGCG31                                             (2) INFORMATION FOR SEQ ID NO:317:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:317:                                     ACACUCAAGGGAACUUGAGCGUGAAUCUGUA31                                             (2) INFORMATION FOR SEQ ID NO:318:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:318:                                     AACUUGAGCGUGAAUCUGUAUCUUGCCGGUC31                                             (2) INFORMATION FOR SEQ ID NO:319:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:319:                                     UGAGCGUGAAUCUGUAUCUUGCCGGUCAUUU31                                             (2) INFORMATION FOR SEQ ID NO:320:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:320:                                     AGCGUGAAUCUGUAUCUUGCCGGUCAUUUUU31                                             (2) INFORMATION FOR SEQ ID NO:321:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:321:                                     CGUGAAUCUGUAUCUUGCCGGUCAUUUUUAU31                                             (2) INFORMATION FOR SEQ ID NO:322:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:322:                                     CUGUAUCUUGCCGGUCAUUUUUAUGUUAUUA31                                             (2) INFORMATION FOR SEQ ID NO:323:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:323:                                     UAUCUUGCCGGUCAUUUUUAUGUUAUUACAG31                                             (2) INFORMATION FOR SEQ ID NO:324:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:324:                                     AUCUUGCCGGUCAUUUUUAUGUUAUUACAGG31                                             (2) INFORMATION FOR SEQ ID NO:325:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:325:                                     UCUUGCCGGUCAUUUUUAUGUUAUUACAGGG31                                             (2) INFORMATION FOR SEQ ID NO:326:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:326:                                     CUUGCCGGUCAUUUUUAUGUUAUUACAGGGC31                                             (2) INFORMATION FOR SEQ ID NO:327:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:327:                                     UUGCCGGUCAUUUUUAUGUUAUUACAGGGCA31                                             (2) INFORMATION FOR SEQ ID NO:328:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:328:                                     CGGUCAUUUUUAUGUUAUUACAGGGCAUUCA31                                             (2) INFORMATION FOR SEQ ID NO:329:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:329:                                     GGUCAUUUUUAUGUUAUUACAGGGCAUUCAA31                                             (2) INFORMATION FOR SEQ ID NO:330:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:330:                                     UCAUUUUUAUGUUAUUACAGGGCAUUCAAAU31                                             (2) INFORMATION FOR SEQ ID NO:331:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:331:                                     CAUUUUUAUGUUAUUACAGGGCAUUCAAAUG31                                             (2) INFORMATION FOR SEQ ID NO:332:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:332:                                     GUUAUUACAGGGCAUUCAAAUGGGCUGCUGC31                                             (2) INFORMATION FOR SEQ ID NO:333:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:333:                                     UUAUUACAGGGCAUUCAAAUGGGCUGCUGCU31                                             (2) INFORMATION FOR SEQ ID NO:334:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:334:                                     AAAUGGGCUGCUGCUUAGCUUGCACCUUGUC31                                             (2) INFORMATION FOR SEQ ID NO:335:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:335:                                     AAUGGGCUGCUGCUUAGCUUGCACCUUGUCA31                                             (2) INFORMATION FOR SEQ ID NO:336:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:336:                                     GGCUGCUGCUUAGCUUGCACCUUGUCACAUA31                                             (2) INFORMATION FOR SEQ ID NO:337:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:337:                                     GCUUAGCUUGCACCUUGUCACAUAGAGUGAU31                                             (2) INFORMATION FOR SEQ ID NO:338:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:338:                                     UAGCUUGCACCUUGUCACAUAGAGUGAUCUU31                                             (2) INFORMATION FOR SEQ ID NO:339:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:339:                                     UGCACCUUGUCACAUAGAGUGAUCUUUCCCA31                                             (2) INFORMATION FOR SEQ ID NO:340:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:340:                                     GUCACAUAGAGUGAUCUUUCCCAAGAGAAGG31                                             (2) INFORMATION FOR SEQ ID NO:341:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:341:                                     CACAUAGAGUGAUCUUUCCCAAGAGAAGGGG31                                             (2) INFORMATION FOR SEQ ID NO:342:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:342:                                     ACAUAGAGUGAUCUUUCCCAAGAGAAGGGGA31                                             (2) INFORMATION FOR SEQ ID NO:343:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:343:                                     CAUAGAGUGAUCUUUCCCAAGAGAAGGGGAA31                                             (2) INFORMATION FOR SEQ ID NO:344:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:344:                                     AGAAGGGGAAGCACUCGUGUGCAACAGACAA31                                             (2) INFORMATION FOR SEQ ID NO:345:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:345:                                     CAGACAAGUGACUGUAUCUGUGUAGACUAUU31                                             (2) INFORMATION FOR SEQ ID NO:346:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:346:                                     GACAAGUGACUGUAUCUGUGUAGACUAUUUG31                                             (2) INFORMATION FOR SEQ ID NO:347:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:347:                                     UGACUGUAUCUGUGUAGACUAUUUGCUUAUU31                                             (2) INFORMATION FOR SEQ ID NO:348:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:348:                                     GUAUCUGUGUAGACUAUUUGCUUAUUUAAUA31                                             (2) INFORMATION FOR SEQ ID NO:349:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:349:                                     AUCUGUGUAGACUAUUUGCUUAUUUAAUAAA31                                             (2) INFORMATION FOR SEQ ID NO:350:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:350:                                     UCUGUGUAGACUAUUUGCUUAUUUAAUAAAG31                                             (2) INFORMATION FOR SEQ ID NO:351:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:351:                                     UGUAGACUAUUUGCUUAUUUAAUAAAGACGA31                                             (2) INFORMATION FOR SEQ ID NO:352:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:352:                                     GUAGACUAUUUGCUUAUUUAAUAAAGACGAU31                                             (2) INFORMATION FOR SEQ ID NO:353:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:353:                                     AGACUAUUUGCUUAUUUAAUAAAGACGAUUU31                                             (2) INFORMATION FOR SEQ ID NO:354:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:354:                                     GACUAUUUGCUUAUUUAAUAAAGACGAUUUG31                                             (2) INFORMATION FOR SEQ ID NO:355:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:355:                                     ACUAUUUGCUUAUUUAAUAAAGACGAUUUGU31                                             (2) INFORMATION FOR SEQ ID NO:356:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 31 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:356:                                     AUUUGCUUAUUUAAUAAAGACGAUUUGUCAG31                                             (2) INFORMATION FOR SEQ ID NO:357:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 29 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:357:                                     UUUAAUAAAGACGAUUUGUCAGUUGUUUU29                                               (2) INFORMATION FOR SEQ ID NO:358:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 28 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:358:                                     UUAAUAAAGACGAUUUGUCAGUUGUUUU28                                                (2) INFORMATION FOR SEQ ID NO:359:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 25 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:359:                                     AUAAAGACGAUUUGUCAGUUGUUUU25                                                   (2) INFORMATION FOR SEQ ID NO:360:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:360:                                     CUACUGUUGCUGUGCGUGGCAGU23                                                     (2) INFORMATION FOR SEQ ID NO:361:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:361:                                     UGGCAGUUUGCUCAGCCUAUCCA23                                                     (2) INFORMATION FOR SEQ ID NO:362:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:362:                                     AAACAGUUUGUUAGGAGAAAGGA23                                                     (2) INFORMATION FOR SEQ ID NO:363:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:363:                                     AUGCUGUUGAUUCUGCUGUUGAG23                                                     (2) INFORMATION FOR SEQ ID NO:364:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:364:                                     CUGCUGUUGAGAAAGCUCUGAAA23                                                     (2) INFORMATION FOR SEQ ID NO:365:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:365:                                     UCACAGACCUGACUCGGUUCCGC23                                                     (2) INFORMATION FOR SEQ ID NO:366:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:366:                                     AUGCUGUUUUUGAAGAAUUUGGG23                                                     (2) INFORMATION FOR SEQ ID NO:367:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 23 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:367:                                     UCACAGUUGGAGUUUGACCCAAA23                                                     (2) INFORMATION FOR SEQ ID NO:368:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 11 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (ix) FEATURE:                                                                 (D) OTHER INFORMATION: The letter "N"stands for any                           base. The letter "H"stands                                                    for A, U, or C.                                                               (xi) SEQUENCE DESCRIPTION: SEQ ID NO:368:                                     NNNNUHNNNNN11                                                                 (2) INFORMATION FOR SEQ ID NO:369:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 28 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (ix) FEATURE:                                                                 (D) OTHER INFORMATION: The letter "N"stands for any                           base.                                                                         (xi) SEQUENCE DESCRIPTION: SEQ ID NO:369:                                     NNNNNCUGANGAGNNNNNNCGAAANNNN28                                                (2) INFORMATION FOR SEQ ID NO:370:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (ix) FEATURE:                                                                 (D) OTHER INFORMATION: The letter "N"stands for any                           base. The leter "Y"stands for                                                 U or C. The letter "H"stands                                                  for A, U, or C.                                                               (xi) SEQUENCE DESCRIPTION: SEQ ID NO:370:                                     NNNNNNNYNGHYNNN15                                                             (2) INFORMATION FOR SEQ ID NO:371:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 47 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (ix) FEATURE:                                                                 (D) OTHER INFORMATION: The letter "N"stands for any                           base.                                                                         (xi) SEQUENCE DESCRIPTION: SEQ ID NO:371:                                     NNNNGAAGNNNNNNNNNNNAAAHANNNNNNNACAUUACNNNNNNNNN47                             (2) INFORMATION FOR SEQ ID NO:372:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 85 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:372:                                     UGGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACAUUCCGAGGGGACCG60                UCCCCUCGGUAAUGGCGAAUGGGAC85                                                   (2) INFORMATION FOR SEQ ID NO:373:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 176 base pairs                                                    (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:373:                                     GGGAAAGCUUGCGAAGGGCGUCGUCGCCCCGAGCGGUAGUAAGCAGGGAACUCACCUCCA60                AUUUCAGUACUGAAAUUGUCGUAGCAGUUGACUACUGUUAUGUGAUUGGUAGAGGCUAAG120               UGACGGUAUUGGCGUAAGUCAGUAUUGCAGCACAGCACAAGCCCGCUUGCGAGAAU176                   (2) INFORMATION FOR SEQ ID NO:374:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 12 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:374:                                     GGCCGAAAGGCC12                                                                (2) INFORMATION FOR SEQ ID NO:375:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:375:                                     GUUGUCUCCUGAAGAGCACGAAAGUGCGAAAUGCCUUG38                                      (2) INFORMATION FOR SEQ ID NO:376:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:376:                                     UUAGCUCCUGAUGAGGCCGAAAGGCCGAAAUGUUGU36                                        (2) INFORMATION FOR SEQ ID NO:377:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:377:                                     GAGGUCGCUGAUGAGGCCGAAAGGCCGAAAGUAGUU36                                        (2) INFORMATION FOR SEQ ID NO:378:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:378:                                     CUCCAUUCUGAUGAGGCCGAAAGGCCGAAAUCCCUG36                                        (2) INFORMATION FOR SEQ ID NO:379:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:379:                                     UCUCCAUCUGAUGAGGCCGAAAGGCCGAAAAUCCCU36                                        (2) INFORMATION FOR SEQ ID NO:380:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:380:                                     CAUCAUCACUGAAGAGCACGAAAGUGCGAAAGUGGGCA38                                      (2) INFORMATION FOR SEQ ID NO:381:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:381:                                     UCAUCAUCCUGAAGAGCACGAAAGUGCGAAAAGUGGGC38                                      (2) INFORMATION FOR SEQ ID NO:382:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:382:                                     CCUGUUGCUGAUGAGGCCGAAAGGCCGAAAUCCUUU36                                        (2) INFORMATION FOR SEQ ID NO:383:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:383:                                     ACCCAGGCUGAUGAGGCCGAAAGGCCGAAAGUGGCC36                                        (2) INFORMATION FOR SEQ ID NO:384:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:384:                                     GGGACUGCUGAUGAGGCCGAAAGGCCGAAAUGCCAU36                                        (2) INFORMATION FOR SEQ ID NO:385:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385:                                     UCUGGAGGCUGAAGAGCACGAAAGUGCGAAACAGGUUC38                                      (2) INFORMATION FOR SEQ ID NO:386:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:386:                                     CCCCUCACUGAUGAGGCCGAAAGGCCGAAAGUGCUG36                                        (2) INFORMATION FOR SEQ ID NO:387:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:387:                                     CCUGAGGCUGAUGAGGCCGAAAGGCCGAAAUUUGCG36                                        (2) INFORMATION FOR SEQ ID NO:388:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:388:                                     UGGCCCACUGAUGAGGCCGAAAGGCCGAAAAUUGAU36                                        (2) INFORMATION FOR SEQ ID NO:389:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:389:                                     UUUCCUCUCUGAUGAGCACGAAAGUGCGAAAUGGCCCA38                                      (2) INFORMATION FOR SEQ ID NO:390:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390:                                     CCUUAUCACUGAAGAGCACGAAAGUGCGAAAAAUGGCU38                                      (2) INFORMATION FOR SEQ ID NO:391:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:391:                                     UCUCCAGCUGAUGAGGCCGAAAGGCCGAAAUUUGUC36                                        (2) INFORMATION FOR SEQ ID NO:392:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:392:                                     UCUCAUCACUGAAGAGCACGAAAGUGCGAAAUCUCCAG38                                      (2) INFORMATION FOR SEQ ID NO:393:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:393:                                     AUCCCUGCUGAUGAGGCCGAAAGGCCGAAAAAGUCU36                                        (2) INFORMATION FOR SEQ ID NO:394:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:394:                                     CAGCAUCCUGAUGAGGCCGAAAGGCCGAAAUCUUUG36                                        (2) INFORMATION FOR SEQ ID NO:395:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:395:                                     UCUUCAAACUGAUGAGCACGAAAGUGCGAAACAGCAUC38                                      (2) INFORMATION FOR SEQ ID NO:396:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:396:                                     AAACUCCCUGAUGAGGCCGAAAGGCCGAAACUGUGA36                                        (2) INFORMATION FOR SEQ ID NO:397:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:397:                                     CAAGGCAUCAAGACAGC17                                                           (2) INFORMATION FOR SEQ ID NO:398:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:398:                                     GACAGCAUAGAGCUGAG17                                                           (2) INFORMATION FOR SEQ ID NO:399:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:399:                                     AGCUGAGUAAAGCCAAU17                                                           (2) INFORMATION FOR SEQ ID NO:400:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:400:                                     UGAAAACUCUUCCAACC17                                                           (2) INFORMATION FOR SEQ ID NO:401:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:401:                                     AAAACUCUUCCAACCCU17                                                           (2) INFORMATION FOR SEQ ID NO:402:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:402:                                     AAACUCUUCCAACCCUG17                                                           (2) INFORMATION FOR SEQ ID NO:403:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:403:                                     ACCCUGCUACUGCUGUG17                                                           (2) INFORMATION FOR SEQ ID NO:404:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:404:                                     GUGGCGCUUUGCUCAGC17                                                           (2) INFORMATION FOR SEQ ID NO:405:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:405:                                     UGGCGCUUUGCUCAGCC17                                                           (2) INFORMATION FOR SEQ ID NO:406:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:406:                                     GCUUUGCUCAGCCUAUC17                                                           (2) INFORMATION FOR SEQ ID NO:407:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:407:                                     CUCAGCCUAUCCACUGG17                                                           (2) INFORMATION FOR SEQ ID NO:408:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:408:                                     CAGCCUAUCCACUGGAU17                                                           (2) INFORMATION FOR SEQ ID NO:409:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:409:                                     UGGAGCCUCAAGGGAUG17                                                           (2) INFORMATION FOR SEQ ID NO:410:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:410:                                     AUGGACCUUCUUCAGCA17                                                           (2) INFORMATION FOR SEQ ID NO:411:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:411:                                     UGGACCUUCUUCAGCAA17                                                           (2) INFORMATION FOR SEQ ID NO:412:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:412:                                     GACCUUCUUCAGCAAUA17                                                           (2) INFORMATION FOR SEQ ID NO:413:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:413:                                     ACCUUCUUCAGCAAUAU17                                                           (2) INFORMATION FOR SEQ ID NO:414:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:414:                                     UCAGCAAUAUCUGGAAA17                                                           (2) INFORMATION FOR SEQ ID NO:415:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:415:                                     AGCAAUAUCUGGAAAAC17                                                           (2) INFORMATION FOR SEQ ID NO:416:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:416:                                     GGAAAACUACUACAACC17                                                           (2) INFORMATION FOR SEQ ID NO:417:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:417:                                     AAACUACUACAACCUUG17                                                           (2) INFORMATION FOR SEQ ID NO:418:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:418:                                     UACAACCUUGAAAAAGA17                                                           (2) INFORMATION FOR SEQ ID NO:419:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:419:                                     GAAACAGUUUGUUAAAA17                                                           (2) INFORMATION FOR SEQ ID NO:420:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:420:                                     AAACAGUUUGUUAAAAG17                                                           (2) INFORMATION FOR SEQ ID NO:421:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:421:                                     CAGUUUGUUAAAAGAAA17                                                           (2) INFORMATION FOR SEQ ID NO:422:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:422:                                     AGUUUGUUAAAAGAAAG17                                                           (2) INFORMATION FOR SEQ ID NO:423:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:423:                                     AGGACAGUAGUCCUGUU17                                                           (2) INFORMATION FOR SEQ ID NO:424:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:424:                                     ACAGUAGUCCUGUUGUU17                                                           (2) INFORMATION FOR SEQ ID NO:425:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:425:                                     AGUCCUGUUGUUAAAAA17                                                           (2) INFORMATION FOR SEQ ID NO:426:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:426:                                     CCUGUUGUUAAAAAAAU17                                                           (2) INFORMATION FOR SEQ ID NO:427:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:427:                                     CUGUUGUUAAAAAAAUC17                                                           (2) INFORMATION FOR SEQ ID NO:428:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:428:                                     AAAAAAAUCCAAGAAAU17                                                           (2) INFORMATION FOR SEQ ID NO:429:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:429:                                     GCAGAAGUUCCUUGGCU17                                                           (2) INFORMATION FOR SEQ ID NO:430:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:430:                                     CAGAAGUUCCUUGGCUU17                                                           (2) INFORMATION FOR SEQ ID NO:431:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:431:                                     AAGUUCCUUGGCUUGGA17                                                           (2) INFORMATION FOR SEQ ID NO:432:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:432:                                     CCUUGGCUUGGAGGUGA17                                                           (2) INFORMATION FOR SEQ ID NO:433:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:433:                                     GCUGGACUCCAACACCC17                                                           (2) INFORMATION FOR SEQ ID NO:434:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:434:                                     GAGGUGAUACGCAAGCC17                                                           (2) INFORMATION FOR SEQ ID NO:435:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:435:                                     UGUGGCGUUCCUGAUGU17                                                           (2) INFORMATION FOR SEQ ID NO:436:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:436:                                     GUGGCGUUCCUGAUGUU17                                                           (2) INFORMATION FOR SEQ ID NO:437:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:437:                                     CCUGAUGUUGGUCACUU17                                                           (2) INFORMATION FOR SEQ ID NO:438:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:438:                                     AUGUUGGUCACUUCAGU17                                                           (2) INFORMATION FOR SEQ ID NO:439:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:439:                                     UGGUCACUUCAGUACCU17                                                           (2) INFORMATION FOR SEQ ID NO:440:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:440:                                     GGUCACUUCAGUACCUU17                                                           (2) INFORMATION FOR SEQ ID NO:441:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:441:                                     ACUUCAGUACCUUCCCU17                                                           (2) INFORMATION FOR SEQ ID NO:442:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:442:                                     CAGUACCUUCCCUGGCA17                                                           (2) INFORMATION FOR SEQ ID NO:443:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:443:                                     AGUACCUUCCCUGGCAC17                                                           (2) INFORMATION FOR SEQ ID NO:444:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:444:                                     CAAAAACUCACCUAACU17                                                           (2) INFORMATION FOR SEQ ID NO:445:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:445:                                     ACUCACCUAACUUACAG17                                                           (2) INFORMATION FOR SEQ ID NO:446:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:446:                                     ACCUAACUUACAGGAUU17                                                           (2) INFORMATION FOR SEQ ID NO:447:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:447:                                     CCUAACUUACAGGAUUG17                                                           (2) INFORMATION FOR SEQ ID NO:448:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:448:                                     UACAGGAUUGUGAAUUA17                                                           (2) INFORMATION FOR SEQ ID NO:449:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:449:                                     UUGUGAAUUACACACCG17                                                           (2) INFORMATION FOR SEQ ID NO:450:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:450:                                     UGUGAAUUACACACCGG17                                                           (2) INFORMATION FOR SEQ ID NO:451:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:451:                                     CACCGGAUCUGCCAAGA17                                                           (2) INFORMATION FOR SEQ ID NO:452:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:452:                                     GAUGCUGUUGAUGCUGC17                                                           (2) INFORMATION FOR SEQ ID NO:453:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:453:                                     GCUGCCAUUGAGAAAGC17                                                           (2) INFORMATION FOR SEQ ID NO:454:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:454:                                     AGAAAGCUCUGAAGGUC17                                                           (2) INFORMATION FOR SEQ ID NO:455:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:455:                                     CUGAAGGUCUGGGAGGA17                                                           (2) INFORMATION FOR SEQ ID NO:456:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:456:                                     AGGUGACUCCACUCACG17                                                           (2) INFORMATION FOR SEQ ID NO:457:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:457:                                     ACUCCACUCACGUUCUC17                                                           (2) INFORMATION FOR SEQ ID NO:458:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:458:                                     ACUCACGUUCUCCAGGA17                                                           (2) INFORMATION FOR SEQ ID NO:459:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:459:                                     CUCACGUUCUCCAGGAA17                                                           (2) INFORMATION FOR SEQ ID NO:460:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:460:                                     CACGUUCUCCAGGAAGU17                                                           (2) INFORMATION FOR SEQ ID NO:461:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:461:                                     CAGGAAGUAUGAAGGAG17                                                           (2) INFORMATION FOR SEQ ID NO:462:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:462:                                     GCUGACAUAAUGAUCUC17                                                           (2) INFORMATION FOR SEQ ID NO:463:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:463:                                     AUAAUGAUCUCUUUUGG17                                                           (2) INFORMATION FOR SEQ ID NO:464:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:464:                                     AAUGAUCUCUUUUGGAG17                                                           (2) INFORMATION FOR SEQ ID NO:465:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:465:                                     UGAUCUCUUUUGGAGUC17                                                           (2) INFORMATION FOR SEQ ID NO:466:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:466:                                     GAUCUCUUUUGGAGUCC17                                                           (2) INFORMATION FOR SEQ ID NO:467:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:467:                                     AUCUCUUUUGGAGUCCG17                                                           (2) INFORMATION FOR SEQ ID NO:468:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:468:                                     UUUGGAGUCCGAGAACA17                                                           (2) INFORMATION FOR SEQ ID NO:469:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:469:                                     AUGGAGAUUUUAUUCCU17                                                           (2) INFORMATION FOR SEQ ID NO:470:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:470:                                     UGGAGAUUUUAUUCCUU17                                                           (2) INFORMATION FOR SEQ ID NO:471:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:471:                                     GGAGAUUUUAUUCCUUU17                                                           (2) INFORMATION FOR SEQ ID NO:472:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:472:                                     GAGAUUUUAUUCCUUUU17                                                           (2) INFORMATION FOR SEQ ID NO:473:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:473:                                     GAUUUUAUUCCUUUUGA17                                                           (2) INFORMATION FOR SEQ ID NO:474:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:474:                                     AUUUUAUUCCUUUUGAU17                                                           (2) INFORMATION FOR SEQ ID NO:475:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:475:                                     UUAUUCCUUUUGAUGGA17                                                           (2) INFORMATION FOR SEQ ID NO:476:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:476:                                     UAUUCCUUUUGAUGGAC17                                                           (2) INFORMATION FOR SEQ ID NO:477:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:477:                                     AUUCCUUUUGAUGGACC17                                                           (2) INFORMATION FOR SEQ ID NO:478:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:478:                                     GGAAAUGUUUUGGCUCA17                                                           (2) INFORMATION FOR SEQ ID NO:479:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:479:                                     GAAAUGUUUUGGCUCAU17                                                           (2) INFORMATION FOR SEQ ID NO:480:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:480:                                     AAAUGUUUUGGCUCAUG17                                                           (2) INFORMATION FOR SEQ ID NO:481:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:481:                                     UUUUGGCUCAUGCUUAU17                                                           (2) INFORMATION FOR SEQ ID NO:482:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:482:                                     CUCAUGCUUAUGCACCU17                                                           (2) INFORMATION FOR SEQ ID NO:483:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:483:                                     UCAUGCUUAUGCACCUG17                                                           (2) INFORMATION FOR SEQ ID NO:484:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:484:                                     CCAGGAAUUAAUGGAGA17                                                           (2) INFORMATION FOR SEQ ID NO:485:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:485:                                     CAGGAAUUAAUGGAGAU17                                                           (2) INFORMATION FOR SEQ ID NO:486:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:486:                                     UGCCCACUUUGAUGAUG17                                                           (2) INFORMATION FOR SEQ ID NO:487:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:487:                                     GCCCACUUUGAUGAUGA17                                                           (2) INFORMATION FOR SEQ ID NO:488:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:488:                                     CAAAGGAUACAACAGGA17                                                           (2) INFORMATION FOR SEQ ID NO:489:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:489:                                     GAACCAAUUUAUUCCUU17                                                           (2) INFORMATION FOR SEQ ID NO:490:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:490:                                     AACCAAUUUAUUCCUUG17                                                           (2) INFORMATION FOR SEQ ID NO:491:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:491:                                     ACCAAUUUAUUCCUUGU17                                                           (2) INFORMATION FOR SEQ ID NO:492:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:492:                                     CAAUUUAUUCCUUGUUG17                                                           (2) INFORMATION FOR SEQ ID NO:493:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:493:                                     AAUUUAUUCCUUGUUGC17                                                           (2) INFORMATION FOR SEQ ID NO:494:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:494:                                     UUAUUCCUUGUUGCUGC17                                                           (2) INFORMATION FOR SEQ ID NO:495:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:495:                                     UUCCUUGUUGCUGCUCA17                                                           (2) INFORMATION FOR SEQ ID NO:496:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:496:                                     UUGCUGCUCAUGAGCUU17                                                           (2) INFORMATION FOR SEQ ID NO:497:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:497:                                     CAUGAGCUUGGCCACUC17                                                           (2) INFORMATION FOR SEQ ID NO:498:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:498:                                     UGGCCACUCCCUGGGUC17                                                           (2) INFORMATION FOR SEQ ID NO:499:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:499:                                     CCCUGGGUCUGUUUCAC17                                                           (2) INFORMATION FOR SEQ ID NO:500:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:500:                                     GGGUCUGUUUCACUCGG17                                                           (2) INFORMATION FOR SEQ ID NO:501:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:501:                                     GGUCUGUUUCACUCGGC17                                                           (2) INFORMATION FOR SEQ ID NO:502:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:502:                                     GUCUGUUUCACUCGGCC17                                                           (2) INFORMATION FOR SEQ ID NO:503:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:503:                                     GUUUCACUCGGCCAACC17                                                           (2) INFORMATION FOR SEQ ID NO:504:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:504:                                     GCUGAUGUACCCAGUCU17                                                           (2) INFORMATION FOR SEQ ID NO:505:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:505:                                     UACCCAGUCUACAACGC17                                                           (2) INFORMATION FOR SEQ ID NO:506:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:506:                                     CCCAGUCUACAACGCCU17                                                           (2) INFORMATION FOR SEQ ID NO:507:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:507:                                     CAACGCCUUCACAGACC17                                                           (2) INFORMATION FOR SEQ ID NO:508:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:508:                                     AACGCCUUCACAGACCU17                                                           (2) INFORMATION FOR SEQ ID NO:509:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:509:                                     GGCCCGGUUCCGCCUUU17                                                           (2) INFORMATION FOR SEQ ID NO:510:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:510:                                     GCCCGGUUCCGCCUUUC17                                                           (2) INFORMATION FOR SEQ ID NO:511:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:511:                                     UUCCGCCUUUCUCAAGA17                                                           (2) INFORMATION FOR SEQ ID NO:512:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:512:                                     UCCGCCUUUCUCAAGAU17                                                           (2) INFORMATION FOR SEQ ID NO:513:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:513:                                     CCGCCUUUCUCAAGAUG17                                                           (2) INFORMATION FOR SEQ ID NO:514:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:514:                                     GCCUUUCUCAAGAUGAU17                                                           (2) INFORMATION FOR SEQ ID NO:515:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:515:                                     GAUGGCAUCCAAUCCCU17                                                           (2) INFORMATION FOR SEQ ID NO:516:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:516:                                     CAUCCAAUCCCUCUAUG17                                                           (2) INFORMATION FOR SEQ ID NO:517:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:517:                                     CAAUCCCUCUAUGGACC17                                                           (2) INFORMATION FOR SEQ ID NO:518:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:518:                                     AUCCCUCUAUGGACCGG17                                                           (2) INFORMATION FOR SEQ ID NO:519:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:519:                                     CCCUGCCUCUCCUGAUA17                                                           (2) INFORMATION FOR SEQ ID NO:520:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:520:                                     CUGCCUCUCCUGAUAAC17                                                           (2) INFORMATION FOR SEQ ID NO:521:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:521:                                     CUCCUGAUAACUCUGGA17                                                           (2) INFORMATION FOR SEQ ID NO:522:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:522:                                     UGAUAACUCUGGAGUGC17                                                           (2) INFORMATION FOR SEQ ID NO:523:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:523:                                     GAGUGCCUAUGGAACCU17                                                           (2) INFORMATION FOR SEQ ID NO:524:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:524:                                     GAACCUGUCCCUCCAGG17                                                           (2) INFORMATION FOR SEQ ID NO:525:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:525:                                     CUGUCCCUCCAGGAUCU17                                                           (2) INFORMATION FOR SEQ ID NO:526:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:526:                                     UCCAGGAUCUGGGACCC17                                                           (2) INFORMATION FOR SEQ ID NO:527:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:527:                                     ACCCCAGUCAUGUGUGA17                                                           (2) INFORMATION FOR SEQ ID NO:528:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:528:                                     UGUGUGAUCCAGAUCUG17                                                           (2) INFORMATION FOR SEQ ID NO:529:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:529:                                     AUCCAGAUCUGUCCUUC17                                                           (2) INFORMATION FOR SEQ ID NO:530:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:530:                                     AGAUCUGUCCUUCGAUG17                                                           (2) INFORMATION FOR SEQ ID NO:531:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:531:                                     UCUGUCCUUCGAUGCAA17                                                           (2) INFORMATION FOR SEQ ID NO:532:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:532:                                     CUGUCCUUCGAUGCAAU17                                                           (2) INFORMATION FOR SEQ ID NO:533:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:533:                                     GAUGCAAUCAGCACUCU17                                                           (2) INFORMATION FOR SEQ ID NO:534:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:534:                                     UCAGCACUCUGAGGGGA17                                                           (2) INFORMATION FOR SEQ ID NO:535:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:535:                                     GGAGAAAUUCUGUUCUU17                                                           (2) INFORMATION FOR SEQ ID NO:536:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:536:                                     GAGAAAUUCUGUUCUUU17                                                           (2) INFORMATION FOR SEQ ID NO:537:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:537:                                     AAUUCUGUUCUUUAAAG17                                                           (2) INFORMATION FOR SEQ ID NO:538:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:538:                                     AUUCUGUUCUUUAAAGA17                                                           (2) INFORMATION FOR SEQ ID NO:539:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:539:                                     UCUGUUCUUUAAAGACA17                                                           (2) INFORMATION FOR SEQ ID NO:540:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:540:                                     CUGUUCUUUAAAGACAG17                                                           (2) INFORMATION FOR SEQ ID NO:541:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:541:                                     UGUUCUUUAAAGACAGG17                                                           (2) INFORMATION FOR SEQ ID NO:542:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:542:                                     AGACAGGUAUUUCUGGC17                                                           (2) INFORMATION FOR SEQ ID NO:543:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:543:                                     ACAGGUAUUUCUGGCGC17                                                           (2) INFORMATION FOR SEQ ID NO:544:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:544:                                     CAGGUAUUUCUGGCGCA17                                                           (2) INFORMATION FOR SEQ ID NO:545:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:545:                                     AGGUAUUUCUGGCGCAA17                                                           (2) INFORMATION FOR SEQ ID NO:546:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:546:                                     GCGCAAGUCCCUCAGGA17                                                           (2) INFORMATION FOR SEQ ID NO:547:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:547:                                     AAGUCCCUCAGGAUUCU17                                                           (2) INFORMATION FOR SEQ ID NO:548:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:548:                                     CUCAGGAUUCUCGAACC17                                                           (2) INFORMATION FOR SEQ ID NO:549:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:549:                                     UCAGGAUUCUCGAACCU17                                                           (2) INFORMATION FOR SEQ ID NO:550:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:550:                                     AGGAUUCUCGAACCUGA17                                                           (2) INFORMATION FOR SEQ ID NO:551:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:551:                                     ACCUGAGUUUCAUUUGA17                                                           (2) INFORMATION FOR SEQ ID NO:552:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:552:                                     CCUGAGUUUCAUUUGAU17                                                           (2) INFORMATION FOR SEQ ID NO:553:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:553:                                     CUGAGUUUCAUUUGAUC17                                                           (2) INFORMATION FOR SEQ ID NO:554:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:554:                                     AGUUUCAUUUGAUCUCU17                                                           (2) INFORMATION FOR SEQ ID NO:555:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:555:                                     GUUUCAUUUGAUCUCUU17                                                           (2) INFORMATION FOR SEQ ID NO:556:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:556:                                     CAUUUGAUCUCUUCAUU17                                                           (2) INFORMATION FOR SEQ ID NO:557:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:557:                                     UUUGAUCUCUUCAUUCU17                                                           (2) INFORMATION FOR SEQ ID NO:558:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:558:                                     UGAUCUCUUCAUUCUGG17                                                           (2) INFORMATION FOR SEQ ID NO:559:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:559:                                     GAUCUCUUCAUUCUGGC17                                                           (2) INFORMATION FOR SEQ ID NO:560:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:560:                                     CUCUUCAUUCUGGCCAU17                                                           (2) INFORMATION FOR SEQ ID NO:561:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:561:                                     UCUUCAUUCUGGCCAUC17                                                           (2) INFORMATION FOR SEQ ID NO:562:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:562:                                     CUGGCCAUCUCUUCCUU17                                                           (2) INFORMATION FOR SEQ ID NO:563:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:563:                                     GGCCAUCUCUUCCUUCA17                                                           (2) INFORMATION FOR SEQ ID NO:564:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:564:                                     CCAUCUCUUCCUUCAGC17                                                           (2) INFORMATION FOR SEQ ID NO:565:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:565:                                     CAUCUCUUCCUUCAGCA17                                                           (2) INFORMATION FOR SEQ ID NO:566:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:566:                                     CUCUUCCUUCAGCAGUG17                                                           (2) INFORMATION FOR SEQ ID NO:567:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:567:                                     UCUUCCUUCAGCAGUGG17                                                           (2) INFORMATION FOR SEQ ID NO:568:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:568:                                     UGCUGCAUAUGAAGUUA17                                                           (2) INFORMATION FOR SEQ ID NO:569:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:569:                                     UAUGAAGUUAUUAGCAG17                                                           (2) INFORMATION FOR SEQ ID NO:570:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:570:                                     AUGAAGUUAUUAGCAGG17                                                           (2) INFORMATION FOR SEQ ID NO:571:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:571:                                     GAAGUUAUUAGCAGGGA17                                                           (2) INFORMATION FOR SEQ ID NO:572:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:572:                                     AAGUUAUUAGCAGGGAU17                                                           (2) INFORMATION FOR SEQ ID NO:573:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:573:                                     GCAGGGAUACUGUUUUC17                                                           (2) INFORMATION FOR SEQ ID NO:574:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:574:                                     GAUACUGUUUUCAUUUU17                                                           (2) INFORMATION FOR SEQ ID NO:575:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:575:                                     AUACUGUUUUCAUUUUU17                                                           (2) INFORMATION FOR SEQ ID NO:576:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:576:                                     UACUGUUUUCAUUUUUA17                                                           (2) INFORMATION FOR SEQ ID NO:577:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:577:                                     ACUGUUUUCAUUUUUAA17                                                           (2) INFORMATION FOR SEQ ID NO:578:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:578:                                     GUUUUCAUUUUUAAAGG17                                                           (2) INFORMATION FOR SEQ ID NO:579:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:579:                                     UUUUCAUUUUUAAAGGA17                                                           (2) INFORMATION FOR SEQ ID NO:580:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:580:                                     UUUCAUUUUUAAAGGAA17                                                           (2) INFORMATION FOR SEQ ID NO:581:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:581:                                     UUCAUUUUUAAAGGAAC17                                                           (2) INFORMATION FOR SEQ ID NO:582:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:582:                                     UCAUUUUUAAAGGAACU17                                                           (2) INFORMATION FOR SEQ ID NO:583:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:583:                                     AAGGAACUCAGUUCUGG17                                                           (2) INFORMATION FOR SEQ ID NO:584:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:584:                                     AACUCAGUUCUGGGCCA17                                                           (2) INFORMATION FOR SEQ ID NO:585:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:585:                                     ACUCAGUUCUGGGCCAU17                                                           (2) INFORMATION FOR SEQ ID NO:586:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:586:                                     UGGGCCAUUAGAGGAAA17                                                           (2) INFORMATION FOR SEQ ID NO:587:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:587:                                     GGGCCAUUAGAGGAAAU17                                                           (2) INFORMATION FOR SEQ ID NO:588:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:588:                                     AAUGAGGUACAAGCUGG17                                                           (2) INFORMATION FOR SEQ ID NO:589:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:589:                                     AAGCUGGUUACCCAAGA17                                                           (2) INFORMATION FOR SEQ ID NO:590:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:590:                                     AGCUGGUUACCCAAGAA17                                                           (2) INFORMATION FOR SEQ ID NO:591:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:591:                                     AGAAGCAUCCACACCCU17                                                           (2) INFORMATION FOR SEQ ID NO:592:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:592:                                     CCCUGGGUUUCCCUUCA17                                                           (2) INFORMATION FOR SEQ ID NO:593:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:593:                                     CCUGGGUUUCCCUUCAA17                                                           (2) INFORMATION FOR SEQ ID NO:594:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:594:                                     CUGGGUUUCCCUUCAAC17                                                           (2) INFORMATION FOR SEQ ID NO:595:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:595:                                     GUUUCCCUUCAACCAUA17                                                           (2) INFORMATION FOR SEQ ID NO:596:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:596:                                     UUUCCCUUCAACCAUAA17                                                           (2) INFORMATION FOR SEQ ID NO:597:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:597:                                     UCAACCAUAAGAAAAAU17                                                           (2) INFORMATION FOR SEQ ID NO:598:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:598:                                     AGAAAAAUUGAUGCUGC17                                                           (2) INFORMATION FOR SEQ ID NO:599:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:599:                                     GCUGCCAUUUCUGAUAA17                                                           (2) INFORMATION FOR SEQ ID NO:600:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:600:                                     CUGCCAUUUCUGAUAAG17                                                           (2) INFORMATION FOR SEQ ID NO:601:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:601:                                     UGCCAUUUCUGAUAAGG17                                                           (2) INFORMATION FOR SEQ ID NO:602:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:602:                                     UUUCUGAUAAGGAAAGG17                                                           (2) INFORMATION FOR SEQ ID NO:603:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:603:                                     GAAAACAUACUUCUUUG17                                                           (2) INFORMATION FOR SEQ ID NO:604:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:604:                                     AACAUACUUCUUUGUGG17                                                           (2) INFORMATION FOR SEQ ID NO:605:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:605:                                     ACAUACUUCUUUGUGGA17                                                           (2) INFORMATION FOR SEQ ID NO:606:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:606:                                     AUACUUCUUUGUGGAAG17                                                           (2) INFORMATION FOR SEQ ID NO:607:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:607:                                     UACUUCUUUGUGGAAGA17                                                           (2) INFORMATION FOR SEQ ID NO:608:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:608:                                     AGACAAAUACUGGAGGU17                                                           (2) INFORMATION FOR SEQ ID NO:609:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:609:                                     CUGGAGGUUUGAUGAGA17                                                           (2) INFORMATION FOR SEQ ID NO:610:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:610:                                     UGGAGGUUUGAUGAGAA17                                                           (2) INFORMATION FOR SEQ ID NO:611:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:611:                                     GAGACAGUCCCUGGAGC17                                                           (2) INFORMATION FOR SEQ ID NO:612:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:612:                                     GCCAGGCUUUCCCAGAC17                                                           (2) INFORMATION FOR SEQ ID NO:613:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:613:                                     CCAGGCUUUCCCAGACA17                                                           (2) INFORMATION FOR SEQ ID NO:614:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:614:                                     CAGGCUUUCCCAGACAU17                                                           (2) INFORMATION FOR SEQ ID NO:615:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:615:                                     CCAGACAUAUAGCAGAA17                                                           (2) INFORMATION FOR SEQ ID NO:616:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:616:                                     AGACAUAUAGCAGAAGA17                                                           (2) INFORMATION FOR SEQ ID NO:617:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:617:                                     AGAAGACUUUCCAGGAA17                                                           (2) INFORMATION FOR SEQ ID NO:618:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:618:                                     GAAGACUUUCCAGGAAU17                                                           (2) INFORMATION FOR SEQ ID NO:619:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:619:                                     AAGACUUUCCAGGAAUU17                                                           (2) INFORMATION FOR SEQ ID NO:620:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:620:                                     CCAGGAAUUAAUCCAAA17                                                           (2) INFORMATION FOR SEQ ID NO:621:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:621:                                     CAGGAAUUAAUCCAAAG17                                                           (2) INFORMATION FOR SEQ ID NO:622:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:622:                                     GAAUUAAUCCAAAGAUC17                                                           (2) INFORMATION FOR SEQ ID NO:623:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:623:                                     CCAAAGAUCGAUGCUGU17                                                           (2) INFORMATION FOR SEQ ID NO:624:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:624:                                     GAUGCUGUUUUUGAAGC17                                                           (2) INFORMATION FOR SEQ ID NO:625:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:625:                                     AUGCUGUUUUUGAAGCA17                                                           (2) INFORMATION FOR SEQ ID NO:626:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:626:                                     UGCUGUUUUUGAAGCAU17                                                           (2) INFORMATION FOR SEQ ID NO:627:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:627:                                     GCUGUUUUUGAAGCAUU17                                                           (2) INFORMATION FOR SEQ ID NO:628:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:628:                                     UGAAGCAUUUGGGUUUU17                                                           (2) INFORMATION FOR SEQ ID NO:629:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:629:                                     GAAGCAUUUGGGUUUUU17                                                           (2) INFORMATION FOR SEQ ID NO:630:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:630:                                     AUUUGGGUUUUUCUAUU17                                                           (2) INFORMATION FOR SEQ ID NO:631:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:631:                                     UUUGGGUUUUUCUAUUU17                                                           (2) INFORMATION FOR SEQ ID NO:632:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:632:                                     UUGGGUUUUUCUAUUUC17                                                           (2) INFORMATION FOR SEQ ID NO:633:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:633:                                     UGGGUUUUUCUAUUUCU17                                                           (2) INFORMATION FOR SEQ ID NO:634:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:634:                                     GGGUUUUUCUAUUUCUU17                                                           (2) INFORMATION FOR SEQ ID NO:635:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:635:                                     GUUUUUCUAUUUCUUCA17                                                           (2) INFORMATION FOR SEQ ID NO:636:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:636:                                     UUUUCUAUUUCUUCAGU17                                                           (2) INFORMATION FOR SEQ ID NO:637:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:637:                                     UUUCUAUUUCUUCAGUG17                                                           (2) INFORMATION FOR SEQ ID NO:638:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:638:                                     UUCUAUUUCUUCAGUGG17                                                           (2) INFORMATION FOR SEQ ID NO:639:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:639:                                     CUAUUUCUUCAGUGGAU17                                                           (2) INFORMATION FOR SEQ ID NO:640:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:640:                                     UAUUUCUUCAGUGGAUC17                                                           (2) INFORMATION FOR SEQ ID NO:641:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:641:                                     CAGUGGAUCUUCACAGU17                                                           (2) INFORMATION FOR SEQ ID NO:642:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:642:                                     GUGGAUCUUCACAGUCG17                                                           (2) INFORMATION FOR SEQ ID NO:643:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:643:                                     UGGAUCUUCACAGUCGG17                                                           (2) INFORMATION FOR SEQ ID NO:644:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:644:                                     UUCACAGUCGGAGUUUG17                                                           (2) INFORMATION FOR SEQ ID NO:645:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:645:                                     GUCGGAGUUUGACCCAA17                                                           (2) INFORMATION FOR SEQ ID NO:646:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:646:                                     UCGGAGUUUGACCCAAA17                                                           (2) INFORMATION FOR SEQ ID NO:647:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:647:                                     ACACAUGUUUUGAAGAG17                                                           (2) INFORMATION FOR SEQ ID NO:648:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:648:                                     CACAUGUUUUGAAGAGC17                                                           (2) INFORMATION FOR SEQ ID NO:649:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:649:                                     ACAUGUUUUGAAGAGCA17                                                           (2) INFORMATION FOR SEQ ID NO:650:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:650:                                     CAGCUGGUUUCAGUGUU17                                                           (2) INFORMATION FOR SEQ ID NO:651:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:651:                                     AGCUGGUUUCAGUGUUA17                                                           (2) INFORMATION FOR SEQ ID NO:652:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:652:                                     GCUGGUUUCAGUGUUAG17                                                           (2) INFORMATION FOR SEQ ID NO:653:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:653:                                     UUCAGUGUUAGGAGGGG17                                                           (2) INFORMATION FOR SEQ ID NO:654:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:654:                                     UCAGUGUUAGGAGGGGU17                                                           (2) INFORMATION FOR SEQ ID NO:655:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:655:                                     AGGGGUGUAUAGAAGGC17                                                           (2) INFORMATION FOR SEQ ID NO:656:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:656:                                     GGGUGUAUAGAAGGCAC17                                                           (2) INFORMATION FOR SEQ ID NO:657:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:657:                                     AUGAAUGUUUUAAAUGA17                                                           (2) INFORMATION FOR SEQ ID NO:658:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:658:                                     UGAAUGUUUUAAAUGAA17                                                           (2) INFORMATION FOR SEQ ID NO:659:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:659:                                     GAAUGUUUUAAAUGAAC17                                                           (2) INFORMATION FOR SEQ ID NO:660:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:660:                                     AAUGUUUUAAAUGAACC17                                                           (2) INFORMATION FOR SEQ ID NO:661:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:661:                                     AUGAACCUAAUUGUUCA17                                                           (2) INFORMATION FOR SEQ ID NO:662:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:662:                                     AACCUAAUUGUUCAACA17                                                           (2) INFORMATION FOR SEQ ID NO:663:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:663:                                     CUAAUUGUUCAACACUU17                                                           (2) INFORMATION FOR SEQ ID NO:664:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:664:                                     UAAUUGUUCAACACUUA17                                                           (2) INFORMATION FOR SEQ ID NO:665:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:665:                                     UCAACACUUAGGACUUU17                                                           (2) INFORMATION FOR SEQ ID NO:666:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:666:                                     CAACACUUAGGACUUUG17                                                           (2) INFORMATION FOR SEQ ID NO:667:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:667:                                     UUAGGACUUUGUGAGUU17                                                           (2) INFORMATION FOR SEQ ID NO:668:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:668:                                     UAGGACUUUGUGAGUUG17                                                           (2) INFORMATION FOR SEQ ID NO:669:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:669:                                     UUGUGAGUUGAAGUGGC17                                                           (2) INFORMATION FOR SEQ ID NO:670:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:670:                                     AAGUGGCUCAUUUUCUC17                                                           (2) INFORMATION FOR SEQ ID NO:671:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:671:                                     UGGCUCAUUUUCUCCUG17                                                           (2) INFORMATION FOR SEQ ID NO:672:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:672:                                     GGCUCAUUUUCUCCUGC17                                                           (2) INFORMATION FOR SEQ ID NO:673:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:673:                                     GCUCAUUUUCUCCUGCA17                                                           (2) INFORMATION FOR SEQ ID NO:674:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:674:                                     CUCAUUUUCUCCUGCAU17                                                           (2) INFORMATION FOR SEQ ID NO:675:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:675:                                     CAUUUUCUCCUGCAUAU17                                                           (2) INFORMATION FOR SEQ ID NO:676:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:676:                                     UCCUGCAUAUGCUGUGA17                                                           (2) INFORMATION FOR SEQ ID NO:677:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:677:                                     AUGGGAAUCUCGAGCAU17                                                           (2) INFORMATION FOR SEQ ID NO:678:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:678:                                     GGGAAUCUCGAGCAUGA17                                                           (2) INFORMATION FOR SEQ ID NO:679:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:679:                                     AACUGUGUAUCUAACUG17                                                           (2) INFORMATION FOR SEQ ID NO:680:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:680:                                     CUGUGUAUCUAACUGGA17                                                           (2) INFORMATION FOR SEQ ID NO:681:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:681:                                     GUGUAUCUAACUGGACU17                                                           (2) INFORMATION FOR SEQ ID NO:682:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:682:                                     ACUGGACUUUGCACAUC17                                                           (2) INFORMATION FOR SEQ ID NO:683:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:683:                                     CUGGACUUUGCACAUCG17                                                           (2) INFORMATION FOR SEQ ID NO:684:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:684:                                     UUGCACAUCGUUACGGG17                                                           (2) INFORMATION FOR SEQ ID NO:685:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:685:                                     CACAUCGUUACGGGUGU17                                                           (2) INFORMATION FOR SEQ ID NO:686:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:686:                                     ACAUCGUUACGGGUGUU17                                                           (2) INFORMATION FOR SEQ ID NO:687:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:687:                                     ACGGGUGUUCAAACAGG17                                                           (2) INFORMATION FOR SEQ ID NO:688:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:688:                                     CGGGUGUUCAAACAGGC17                                                           (2) INFORMATION FOR SEQ ID NO:689:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:689:                                     CUGCUGCUUAGCUUGCA17                                                           (2) INFORMATION FOR SEQ ID NO:690:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:690:                                     UGCUGCUUAGCUUGCAC17                                                           (2) INFORMATION FOR SEQ ID NO:691:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:691:                                     GCUUAGCUUGCACUUGA17                                                           (2) INFORMATION FOR SEQ ID NO:692:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:692:                                     CUUGCACUUGAUCACAU17                                                           (2) INFORMATION FOR SEQ ID NO:693:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:693:                                     CACUUGAUCACAUGGAA17                                                           (2) INFORMATION FOR SEQ ID NO:694:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:694:                                     AGGGAGCUUCCACGAGA17                                                           (2) INFORMATION FOR SEQ ID NO:695:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:695:                                     GGGAGCUUCCACGAGAC17                                                           (2) INFORMATION FOR SEQ ID NO:696:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:696:                                     GGGGAAGUACUCAUGUG17                                                           (2) INFORMATION FOR SEQ ID NO:697:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:697:                                     GAAGUACUCAUGUGUGA17                                                           (2) INFORMATION FOR SEQ ID NO:698:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:698:                                     CGAGUGAUUGUGUCUAU17                                                           (2) INFORMATION FOR SEQ ID NO:699:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:699:                                     GAUUGUGUCUAUGUGGA17                                                           (2) INFORMATION FOR SEQ ID NO:700:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:700:                                     UUGUGUCUAUGUGGAUU17                                                           (2) INFORMATION FOR SEQ ID NO:701:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:701:                                     AUGUGGAUUAUUUGCCC17                                                           (2) INFORMATION FOR SEQ ID NO:702:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:702:                                     UGUGGAUUAUUUGCCCA17                                                           (2) INFORMATION FOR SEQ ID NO:703:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:703:                                     UGGAUUAUUUGCCCAUU17                                                           (2) INFORMATION FOR SEQ ID NO:704:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:704:                                     GGAUUAUUUGCCCAUUA17                                                           (2) INFORMATION FOR SEQ ID NO:705:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:705:                                     UUGCCCAUUAUUUAAUA17                                                           (2) INFORMATION FOR SEQ ID NO:706:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:706:                                     UGCCCAUUAUUUAAUAA17                                                           (2) INFORMATION FOR SEQ ID NO:707:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:707:                                     CCCAUUAUUUAAUAAAG17                                                           (2) INFORMATION FOR SEQ ID NO:708:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:708:                                     CCAUUAUUUAAUAAAGA17                                                           (2) INFORMATION FOR SEQ ID NO:709:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:709:                                     CAUUAUUUAAUAAAGAG17                                                           (2) INFORMATION FOR SEQ ID NO:710:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:710:                                     UAUUUAAUAAAGAGGAU17                                                           (2) INFORMATION FOR SEQ ID NO:711:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 17 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:711:                                     AAGAGGAUUUGUCAAUU17                                                           (2) INFORMATION FOR SEQ ID NO:712:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:712:                                     GCUGUCUUCUGAUGAGGCCGAAAGGCCGAAAUGCCUUG38                                      (2) INFORMATION FOR SEQ ID NO:713:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:713:                                     CUCAGCUCCUGAUGAGGCCGAAAGGCCGAAAUGCUGUC38                                      (2) INFORMATION FOR SEQ ID NO:714:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:714:                                     AUUGGCUUCUGAUGAGGCCGAAAGGCCGAAACUCAGCU38                                      (2) INFORMATION FOR SEQ ID NO:715:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:715:                                     GGUUGGAACUGAUGAGGCCGAAAGGCCGAAAGUUUUCA38                                      (2) INFORMATION FOR SEQ ID NO:716:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:716:                                     AGGGUUGGCUGAUGAGGCCGAAAGGCCGAAAGAGUUUU38                                      (2) INFORMATION FOR SEQ ID NO:717:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:717:                                     CAGGGUUGCUGAUGAGGCCGAAAGGCCGAAAAGAGUUU38                                      (2) INFORMATION FOR SEQ ID NO:718:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:718:                                     CACAGCAGCUGAUGAGGCCGAAAGGCCGAAAGCAGGGU38                                      (2) INFORMATION FOR SEQ ID NO:719:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:719:                                     GCUGAGCACUGAUGAGGCCGAAAGGCCGAAAGCGCCAC38                                      (2) INFORMATION FOR SEQ ID NO:720:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:720:                                     GGCUGAGCCUGAUGAGGCCGAAAGGCCGAAAAGCGCCA38                                      (2) INFORMATION FOR SEQ ID NO:721:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:721:                                     GAUAGGCUCUGAUGAGGCCGAAAGGCCGAAAGCAAAGC38                                      (2) INFORMATION FOR SEQ ID NO:722:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:722:                                     CCAGUGGACUGAUGAGGCCGAAAGGCCGAAAGGCUGAG38                                      (2) INFORMATION FOR SEQ ID NO:723:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:723:                                     AUCCAGUGCUGAUGAGGCCGAAAGGCCGAAAUAGGCUG38                                      (2) INFORMATION FOR SEQ ID NO:724:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:724:                                     CAUCCCUUCUGAUGAGGCCGAAAGGCCGAAAGGCUCCA38                                      (2) INFORMATION FOR SEQ ID NO:725:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:725:                                     UGCUGAAGCUGAUGAGGCCGAAAGGCCGAAAGGUCCAU38                                      (2) INFORMATION FOR SEQ ID NO:726:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:726:                                     UUGCUGAACUGAUGAGGCCGAAAGGCCGAAAAGGUCCA38                                      (2) INFORMATION FOR SEQ ID NO:727:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:727:                                     UAUUGCUGCUGAUGAGGCCGAAAGGCCGAAAGAAGGUC38                                      (2) INFORMATION FOR SEQ ID NO:728:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:728:                                     AUAUUGCUCUGAUGAGGCCGAAAGGCCGAAAAGAAGGU38                                      (2) INFORMATION FOR SEQ ID NO:729:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:729:                                     UUUCCAGACUGAUGAGGCCGAAAGGCCGAAAUUGCUGA38                                      (2) INFORMATION FOR SEQ ID NO:730:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:730:                                     GUUUUCCACUGAUGAGGCCGAAAGGCCGAAAUAUUGCU38                                      (2) INFORMATION FOR SEQ ID NO:731:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:731:                                     GGUUGUAGCUGAUGAGGCCGAAAGGCCGAAAGUUUUCC38                                      (2) INFORMATION FOR SEQ ID NO:732:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:732:                                     CAAGGUUGCUGAUGAGGCCGAAAGGCCGAAAGUAGUUU38                                      (2) INFORMATION FOR SEQ ID NO:733:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:733:                                     UCUUUUUCCUGAUGAGGCCGAAAGGCCGAAAGGUUGUA38                                      (2) INFORMATION FOR SEQ ID NO:734:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:734:                                     UUUUAACACUGAUGAGGCCGAAAGGCCGAAACUGUUUC38                                      (2) INFORMATION FOR SEQ ID NO:735:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:735:                                     CUUUUAACCUGAUGAGGCCGAAAGGCCGAAAACUGUUU38                                      (2) INFORMATION FOR SEQ ID NO:736:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:736:                                     UUUCUUUUCUGAUGAGGCCGAAAGGCCGAAACAAACUG38                                      (2) INFORMATION FOR SEQ ID NO:737:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:737:                                     CUUUCUUUCUGAUGAGGCCGAAAGGCCGAAAACAAACU38                                      (2) INFORMATION FOR SEQ ID NO:738:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:738:                                     AACAGGACCUGAUGAGGCCGAAAGGCCGAAACUGUCCU38                                      (2) INFORMATION FOR SEQ ID NO:739:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:739:                                     AACAACAGCUGAUGAGGCCGAAAGGCCGAAACUACUGU38                                      (2) INFORMATION FOR SEQ ID NO:740:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:740:                                     UUUUUAACCUGAUGAGGCCGAAAGGCCGAAACAGGACU38                                      (2) INFORMATION FOR SEQ ID NO:741:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:741:                                     AUUUUUUUCUGAUGAGGCCGAAAGGCCGAAACAACAGG38                                      (2) INFORMATION FOR SEQ ID NO:742:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:742:                                     GAUUUUUUCUGAUGAGGCCGAAAGGCCGAAAACAACAG38                                      (2) INFORMATION FOR SEQ ID NO:743:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:743:                                     AUUUCUUGCUGAUGAGGCCGAAAGGCCGAAAUUUUUUU38                                      (2) INFORMATION FOR SEQ ID NO:744:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:744:                                     AGCCAAGGCUGAUGAGGCCGAAAGGCCGAAACUUCUGC38                                      (2) INFORMATION FOR SEQ ID NO:745:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:745:                                     AAGCCAAGCUGAUGAGGCCGAAAGGCCGAAAACUUCUG38                                      (2) INFORMATION FOR SEQ ID NO:746:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:746:                                     UCCAAGCCCUGAUGAGGCCGAAAGGCCGAAAGGAACUU38                                      (2) INFORMATION FOR SEQ ID NO:747:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:747:                                     UCACCUCCCUGAUGAGGCCGAAAGGCCGAAAGCCAAGG38                                      (2) INFORMATION FOR SEQ ID NO:748:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:748:                                     GGGUGUUGCUGAUGAGGCCGAAAGGCCGAAAGUCCAGC38                                      (2) INFORMATION FOR SEQ ID NO:749:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:749:                                     GGCUUGCGCUGAUGAGGCCGAAAGGCCGAAAUCACCUC38                                      (2) INFORMATION FOR SEQ ID NO:750:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:750:                                     ACAUCAGGCUGAUGAGGCCGAAAGGCCGAAACGCCACA38                                      (2) INFORMATION FOR SEQ ID NO:751:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:751:                                     AACAUCAGCUGAUGAGGCCGAAAGGCCGAAAACGCCAC38                                      (2) INFORMATION FOR SEQ ID NO:752:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:752:                                     AAGUGACCCUGAUGAGGCCGAAAGGCCGAAACAUCAGG38                                      (2) INFORMATION FOR SEQ ID NO:753:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:753:                                     ACUGAAGUCUGAUGAGGCCGAAAGGCCGAAACCAACAU38                                      (2) INFORMATION FOR SEQ ID NO:754:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:754:                                     AGGUACUGCUGAUGAGGCCGAAAGGCCGAAAGUGACCA38                                      (2) INFORMATION FOR SEQ ID NO:755:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:755:                                     AAGGUACUCUGAUGAGGCCGAAAGGCCGAAAAGUGACC38                                      (2) INFORMATION FOR SEQ ID NO:756:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:756:                                     AGGGAAGGCUGAUGAGGCCGAAAGGCCGAAACUGAAGU38                                      (2) INFORMATION FOR SEQ ID NO:757:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:757:                                     UGCCAGGGCUGAUGAGGCCGAAAGGCCGAAAGGUACUG38                                      (2) INFORMATION FOR SEQ ID NO:758:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:758:                                     GUGCCAGGCUGAUGAGGCCGAAAGGCCGAAAAGGUACU38                                      (2) INFORMATION FOR SEQ ID NO:759:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:759:                                     AGUUAGGUCUGAUGAGGCCGAAAGGCCGAAAGUUUUUG38                                      (2) INFORMATION FOR SEQ ID NO:760:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:760:                                     CUGUAAGUCUGAUGAGGCCGAAAGGCCGAAAGGUGAGU38                                      (2) INFORMATION FOR SEQ ID NO:761:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:761:                                     AAUCCUGUCUGAUGAGGCCGAAAGGCCGAAAGUUAGGU38                                      (2) INFORMATION FOR SEQ ID NO:762:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:762:                                     CAAUCCUGCUGAUGAGGCCGAAAGGCCGAAAAGUUAGG38                                      (2) INFORMATION FOR SEQ ID NO:763:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:763:                                     UAAUUCACCUGAUGAGGCCGAAAGGCCGAAAUCCUGUA38                                      (2) INFORMATION FOR SEQ ID NO:764:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:764:                                     CGGUGUGUCUGAUGAGGCCGAAAGGCCGAAAUUCACAA38                                      (2) INFORMATION FOR SEQ ID NO:765:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:765:                                     CCGGUGUGCUGAUGAGGCCGAAAGGCCGAAAAUUCACA38                                      (2) INFORMATION FOR SEQ ID NO:766:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:766:                                     UCUUGGCACUGAUGAGGCCGAAAGGCCGAAAUCCGGUG38                                      (2) INFORMATION FOR SEQ ID NO:767:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:767:                                     GCAGCAUCCUGAUGAGGCCGAAAGGCCGAAACAGCAUC38                                      (2) INFORMATION FOR SEQ ID NO:768:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:768:                                     GCUUUCUCCUGAUGAGGCCGAAAGGCCGAAAUGGCAGC38                                      (2) INFORMATION FOR SEQ ID NO:769:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:769:                                     GACCUUCACUGAUGAGGCCGAAAGGCCGAAAGCUUUCU38                                      (2) INFORMATION FOR SEQ ID NO:770:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:770:                                     UCCUCCCACUGAUGAGGCCGAAAGGCCGAAACCUUCAG38                                      (2) INFORMATION FOR SEQ ID NO:771:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:771:                                     CGUGAGUGCUGAUGAGGCCGAAAGGCCGAAAGUCACCU38                                      (2) INFORMATION FOR SEQ ID NO:772:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:772:                                     GAGAACGUCUGAUGAGGCCGAAAGGCCGAAAGUGGAGU38                                      (2) INFORMATION FOR SEQ ID NO:773:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:773:                                     UCCUGGAGCUGAUGAGGCCGAAAGGCCGAAACGUGAGU38                                      (2) INFORMATION FOR SEQ ID NO:774:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:774:                                     UUCCUGGACUGAUGAGGCCGAAAGGCCGAAAACGUGAG38                                      (2) INFORMATION FOR SEQ ID NO:775:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:775:                                     ACUUCCUGCUGAUGAGGCCGAAAGGCCGAAAGAACGUG38                                      (2) INFORMATION FOR SEQ ID NO:776:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:776:                                     CUCCUUCACUGAUGAGGCCGAAAGGCCGAAACUUCCUG38                                      (2) INFORMATION FOR SEQ ID NO:777:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:777:                                     GAGAUCAUCUGAUGAGGCCGAAAGGCCGAAAUGUCAGC38                                      (2) INFORMATION FOR SEQ ID NO:778:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:778:                                     CCAAAAGACUGAUGAGGCCGAAAGGCCGAAAUCAUUAU38                                      (2) INFORMATION FOR SEQ ID NO:779:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:779:                                     CUCCAAAACUGAUGAGGCCGAAAGGCCGAAAGAUCAUU38                                      (2) INFORMATION FOR SEQ ID NO:780:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:780:                                     GACUCCAACUGAUGAGGCCGAAAGGCCGAAAGAGAUCA38                                      (2) INFORMATION FOR SEQ ID NO:781:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:781:                                     GGACUCCACUGAUGAGGCCGAAAGGCCGAAAAGAGAUC38                                      (2) INFORMATION FOR SEQ ID NO:782:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:782:                                     CGGACUCCCUGAUGAGGCCGAAAGGCCGAAAAAGAGAU38                                      (2) INFORMATION FOR SEQ ID NO:783:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:783:                                     UGUUCUCGCUGAUGAGGCCGAAAGGCCGAAACUCCAAA38                                      (2) INFORMATION FOR SEQ ID NO:784:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:784:                                     AGGAAUAACUGAUGAGGCCGAAAGGCCGAAAUCUCCAU38                                      (2) INFORMATION FOR SEQ ID NO:785:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:785:                                     AAGGAAUACUGAUGAGGCCGAAAGGCCGAAAAUCUCCA38                                      (2) INFORMATION FOR SEQ ID NO:786:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:786:                                     AAAGGAAUCUGAUGAGGCCGAAAGGCCGAAAAAUCUCC38                                      (2) INFORMATION FOR SEQ ID NO:787:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:787:                                     AAAAGGAACUGAUGAGGCCGAAAGGCCGAAAAAAUCUC38                                      (2) INFORMATION FOR SEQ ID NO:788:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:788:                                     UCAAAAGGCUGAUGAGGCCGAAAGGCCGAAAUAAAAUC38                                      (2) INFORMATION FOR SEQ ID NO:789:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:789:                                     AUCAAAAGCUGAUGAGGCCGAAAGGCCGAAAAUAAAAU38                                      (2) INFORMATION FOR SEQ ID NO:790:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:790:                                     UCCAUCAACUGAUGAGGCCGAAAGGCCGAAAGGAAUAA38                                      (2) INFORMATION FOR SEQ ID NO:791:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:791:                                     GUCCAUCACUGAUGAGGCCGAAAGGCCGAAAAGGAAUA38                                      (2) INFORMATION FOR SEQ ID NO:792:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:792:                                     GGUCCAUCCUGAUGAGGCCGAAAGGCCGAAAAAGGAAU38                                      (2) INFORMATION FOR SEQ ID NO:793:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:793:                                     UGAGCCAACUGAUGAGGCCGAAAGGCCGAAACAUUUCC38                                      (2) INFORMATION FOR SEQ ID NO:794:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:794:                                     AUGAGCCACUGAUGAGGCCGAAAGGCCGAAAACAUUUC38                                      (2) INFORMATION FOR SEQ ID NO:795:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:795:                                     CAUGAGCCCUGAUGAGGCCGAAAGGCCGAAAAACAUUU38                                      (2) INFORMATION FOR SEQ ID NO:796:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:796:                                     AUAAGCAUCUGAUGAGGCCGAAAGGCCGAAAGCCAAAA38                                      (2) INFORMATION FOR SEQ ID NO:797:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:797:                                     AGGUGCAUCUGAUGAGGCCGAAAGGCCGAAAGCAUGAG38                                      (2) INFORMATION FOR SEQ ID NO:798:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:798:                                     CAGGUGCACUGAUGAGGCCGAAAGGCCGAAAAGCAUGA38                                      (2) INFORMATION FOR SEQ ID NO:799:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:799:                                     UCUCCAUUCUGAUGAGGCCGAAAGGCCGAAAUUCCUGG38                                      (2) INFORMATION FOR SEQ ID NO:800:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:800:                                     AUCUCCAUCUGAUGAGGCCGAAAGGCCGAAAAUUCCUG38                                      (2) INFORMATION FOR SEQ ID NO:801:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:801:                                     CAUCAUCACUGAUGAGGCCGAAAGGCCGAAAGUGGGCA38                                      (2) INFORMATION FOR SEQ ID NO:802:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:802:                                     UCAUCAUCCUGAUGAGGCCGAAAGGCCGAAAAGUGGGC38                                      (2) INFORMATION FOR SEQ ID NO:803:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:803:                                     UCCUGUUGCUGAUGAGGCCGAAAGGCCGAAAUCCUUUG38                                      (2) INFORMATION FOR SEQ ID NO:804:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:804:                                     AAGGAAUACUGAUGAGGCCGAAAGGCCGAAAUUGGUUC38                                      (2) INFORMATION FOR SEQ ID NO:805:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:805:                                     CAAGGAAUCUGAUGAGGCCGAAAGGCCGAAAAUUGGUU38                                      (2) INFORMATION FOR SEQ ID NO:806:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:806:                                     ACAAGGAACUGAUGAGGCCGAAAGGCCGAAAAAUUGGU38                                      (2) INFORMATION FOR SEQ ID NO:807:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:807:                                     CAACAAGGCUGAUGAGGCCGAAAGGCCGAAAUAAAUUG38                                      (2) INFORMATION FOR SEQ ID NO:808:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:808:                                     GCAACAAGCUGAUGAGGCCGAAAGGCCGAAAAUAAAUU38                                      (2) INFORMATION FOR SEQ ID NO:809:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:809:                                     GCAGCAACCUGAUGAGGCCGAAAGGCCGAAAGGAAUAA38                                      (2) INFORMATION FOR SEQ ID NO:810:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:810:                                     UGAGCAGCCUGAUGAGGCCGAAAGGCCGAAACAAGGAA38                                      (2) INFORMATION FOR SEQ ID NO:811:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:811:                                     AAGCUCAUCUGAUGAGGCCGAAAGGCCGAAAGCAGCAA38                                      (2) INFORMATION FOR SEQ ID NO:812:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:812:                                     GAGUGGCCCUGAUGAGGCCGAAAGGCCGAAAGCUCAUG38                                      (2) INFORMATION FOR SEQ ID NO:813:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:813:                                     GACCCAGGCUGAUGAGGCCGAAAGGCCGAAAGUGGCCA38                                      (2) INFORMATION FOR SEQ ID NO:814:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:814:                                     GUGAAACACUGAUGAGGCCGAAAGGCCGAAACCCAGGG38                                      (2) INFORMATION FOR SEQ ID NO:815:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:815:                                     CCGAGUGACUGAUGAGGCCGAAAGGCCGAAACAGACCC38                                      (2) INFORMATION FOR SEQ ID NO:816:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:816:                                     GCCGAGUGCUGAUGAGGCCGAAAGGCCGAAAACAGACC38                                      (2) INFORMATION FOR SEQ ID NO:817:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:817:                                     GGCCGAGUCUGAUGAGGCCGAAAGGCCGAAAAACAGAC38                                      (2) INFORMATION FOR SEQ ID NO:818:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:818:                                     GGUUGGCCCUGAUGAGGCCGAAAGGCCGAAAGUGAAAC38                                      (2) INFORMATION FOR SEQ ID NO:819:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:819:                                     AGACUGGGCUGAUGAGGCCGAAAGGCCGAAACAUCAGC38                                      (2) INFORMATION FOR SEQ ID NO:820:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:820:                                     GCGUUGUACUGAUGAGGCCGAAAGGCCGAAACUGGGUA38                                      (2) INFORMATION FOR SEQ ID NO:821:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:821:                                     AGGCGUUGCUGAUGAGGCCGAAAGGCCGAAAGACUGGG38                                      (2) INFORMATION FOR SEQ ID NO:822:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:822:                                     GGUCUGUGCUGAUGAGGCCGAAAGGCCGAAAGGCGUUG38                                      (2) INFORMATION FOR SEQ ID NO:823:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:823:                                     AGGUCUGUCUGAUGAGGCCGAAAGGCCGAAAAGGCGUU38                                      (2) INFORMATION FOR SEQ ID NO:824:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:824:                                     AAAGGCGGCUGAUGAGGCCGAAAGGCCGAAACCGGGCC38                                      (2) INFORMATION FOR SEQ ID NO:825:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:825:                                     GAAAGGCGCUGAUGAGGCCGAAAGGCCGAAAACCGGGC38                                      (2) INFORMATION FOR SEQ ID NO:826:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:826:                                     UCUUGAGACUGAUGAGGCCGAAAGGCCGAAAGGCGGAA38                                      (2) INFORMATION FOR SEQ ID NO:827:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:827:                                     AUCUUGAGCUGAUGAGGCCGAAAGGCCGAAAAGGCGGA38                                      (2) INFORMATION FOR SEQ ID NO:828:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:828:                                     CAUCUUGACUGAUGAGGCCGAAAGGCCGAAAAAGGCGG38                                      (2) INFORMATION FOR SEQ ID NO:829:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:829:                                     AUCAUCUUCUGAUGAGGCCGAAAGGCCGAAAGAAAGGC38                                      (2) INFORMATION FOR SEQ ID NO:830:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:830:                                     AGGGAUUGCUGAUGAGGCCGAAAGGCCGAAAUGCCAUC38                                      (2) INFORMATION FOR SEQ ID NO:831:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:831:                                     CAUAGAGGCUGAUGAGGCCGAAAGGCCGAAAUUGGAUG38                                      (2) INFORMATION FOR SEQ ID NO:832:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:832:                                     GGUCCAUACUGAUGAGGCCGAAAGGCCGAAAGGGAUUG38                                      (2) INFORMATION FOR SEQ ID NO:833:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:833:                                     CCGGUCCACUGAUGAGGCCGAAAGGCCGAAAGAGGGAU38                                      (2) INFORMATION FOR SEQ ID NO:834:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:834:                                     UAUCAGGACUGAUGAGGCCGAAAGGCCGAAAGGCAGGG38                                      (2) INFORMATION FOR SEQ ID NO:835:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:835:                                     GUUAUCAGCUGAUGAGGCCGAAAGGCCGAAAGAGGCAG38                                      (2) INFORMATION FOR SEQ ID NO:836:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:836:                                     UCCAGAGUCUGAUGAGGCCGAAAGGCCGAAAUCAGGAG38                                      (2) INFORMATION FOR SEQ ID NO:837:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:837:                                     GCACUCCACUGAUGAGGCCGAAAGGCCGAAAGUUAUCA38                                      (2) INFORMATION FOR SEQ ID NO:838:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:838:                                     AGGUUCCACUGAUGAGGCCGAAAGGCCGAAAGGCACUC38                                      (2) INFORMATION FOR SEQ ID NO:839:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:839:                                     CCUGGAGGCUGAUGAGGCCGAAAGGCCGAAACAGGUUC38                                      (2) INFORMATION FOR SEQ ID NO:840:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:840:                                     AGAUCCUGCUGAUGAGGCCGAAAGGCCGAAAGGGACAG38                                      (2) INFORMATION FOR SEQ ID NO:841:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:841:                                     GGGUCCCACUGAUGAGGCCGAAAGGCCGAAAUCCUGGA38                                      (2) INFORMATION FOR SEQ ID NO:842:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:842:                                     UCACACAUCUGAUGAGGCCGAAAGGCCGAAACUGGGGU38                                      (2) INFORMATION FOR SEQ ID NO:843:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:843:                                     CAGAUCUGCUGAUGAGGCCGAAAGGCCGAAAUCACACA38                                      (2) INFORMATION FOR SEQ ID NO:844:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:844:                                     GAAGGACACUGAUGAGGCCGAAAGGCCGAAAUCUGGAU38                                      (2) INFORMATION FOR SEQ ID NO:845:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:845:                                     CAUCGAAGCUGAUGAGGCCGAAAGGCCGAAACAGAUCU38                                      (2) INFORMATION FOR SEQ ID NO:846:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:846:                                     UUGCAUCGCUGAUGAGGCCGAAAGGCCGAAAGGACAGA38                                      (2) INFORMATION FOR SEQ ID NO:847:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:847:                                     AUUGCAUCCUGAUGAGGCCGAAAGGCCGAAAAGGACAG38                                      (2) INFORMATION FOR SEQ ID NO:848:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:848:                                     AGAGUGCUCUGAUGAGGCCGAAAGGCCGAAAUUGCAUC38                                      (2) INFORMATION FOR SEQ ID NO:849:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:849:                                     UCCCCUCACUGAUGAGGCCGAAAGGCCGAAAGUGCUGA38                                      (2) INFORMATION FOR SEQ ID NO:850:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:850:                                     AAGAACAGCUGAUGAGGCCGAAAGGCCGAAAUUUCUCC38                                      (2) INFORMATION FOR SEQ ID NO:851:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:851:                                     AAAGAACACUGAUGAGGCCGAAAGGCCGAAAAUUUCUC38                                      (2) INFORMATION FOR SEQ ID NO:852:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:852:                                     CUUUAAAGCUGAUGAGGCCGAAAGGCCGAAACAGAAUU38                                      (2) INFORMATION FOR SEQ ID NO:853:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:853:                                     UCUUUAAACUGAUGAGGCCGAAAGGCCGAAAACAGAAU38                                      (2) INFORMATION FOR SEQ ID NO:854:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:854:                                     UGUCUUUACUGAUGAGGCCGAAAGGCCGAAAGAACAGA38                                      (2) INFORMATION FOR SEQ ID NO:855:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:855:                                     CUGUCUUUCUGAUGAGGCCGAAAGGCCGAAAAGAACAG38                                      (2) INFORMATION FOR SEQ ID NO:856:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:856:                                     CCUGUCUUCUGAUGAGGCCGAAAGGCCGAAAAAGAACA38                                      (2) INFORMATION FOR SEQ ID NO:857:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:857:                                     GCCAGAAACUGAUGAGGCCGAAAGGCCGAAACCUGUCU38                                      (2) INFORMATION FOR SEQ ID NO:858:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:858:                                     GCGCCAGACUGAUGAGGCCGAAAGGCCGAAAUACCUGU38                                      (2) INFORMATION FOR SEQ ID NO:859:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:859:                                     UGCGCCAGCUGAUGAGGCCGAAAGGCCGAAAAUACCUG38                                      (2) INFORMATION FOR SEQ ID NO:860:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:860:                                     UUGCGCCACUGAUGAGGCCGAAAGGCCGAAAAAUACCU38                                      (2) INFORMATION FOR SEQ ID NO:861:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:861:                                     UCCUGAGGCUGAUGAGGCCGAAAGGCCGAAACUUGCGC38                                      (2) INFORMATION FOR SEQ ID NO:862:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:862:                                     AGAAUCCUCUGAUGAGGCCGAAAGGCCGAAAGGGACUU38                                      (2) INFORMATION FOR SEQ ID NO:863:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:863:                                     GGUUCGAGCUGAUGAGGCCGAAAGGCCGAAAUCCUGAG38                                      (2) INFORMATION FOR SEQ ID NO:864:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:864:                                     AGGUUCGACUGAUGAGGCCGAAAGGCCGAAAAUCCUGA38                                      (2) INFORMATION FOR SEQ ID NO:865:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:865:                                     UCAGGUUCCUGAUGAGGCCGAAAGGCCGAAAGAAUCCU38                                      (2) INFORMATION FOR SEQ ID NO:866:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:866:                                     UCAAAUGACUGAUGAGGCCGAAAGGCCGAAACUCAGGU38                                      (2) INFORMATION FOR SEQ ID NO:867:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:867:                                     AUCAAAUGCUGAUGAGGCCGAAAGGCCGAAAACUCAGG38                                      (2) INFORMATION FOR SEQ ID NO:868:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:868:                                     GAUCAAAUCUGAUGAGGCCGAAAGGCCGAAAAACUCAG38                                      (2) INFORMATION FOR SEQ ID NO:869:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:869:                                     AGAGAUCACUGAUGAGGCCGAAAGGCCGAAAUGAAACU38                                      (2) INFORMATION FOR SEQ ID NO:870:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:870:                                     AAGAGAUCCUGAUGAGGCCGAAAGGCCGAAAAUGAAAC38                                      (2) INFORMATION FOR SEQ ID NO:871:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:871:                                     AAUGAAGACUGAUGAGGCCGAAAGGCCGAAAUCAAAUG38                                      (2) INFORMATION FOR SEQ ID NO:872:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:872:                                     AGAAUGAACUGAUGAGGCCGAAAGGCCGAAAGAUCAAA38                                      (2) INFORMATION FOR SEQ ID NO:873:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:873:                                     CCAGAAUGCUGAUGAGGCCGAAAGGCCGAAAGAGAUCA38                                      (2) INFORMATION FOR SEQ ID NO:874:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:874:                                     GCCAGAAUCUGAUGAGGCCGAAAGGCCGAAAAGAGAUC38                                      (2) INFORMATION FOR SEQ ID NO:875:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:875:                                     AUGGCCAGCUGAUGAGGCCGAAAGGCCGAAAUGAAGAG38                                      (2) INFORMATION FOR SEQ ID NO:876:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:876:                                     GAUGGCCACUGAUGAGGCCGAAAGGCCGAAAAUGAAGA38                                      (2) INFORMATION FOR SEQ ID NO:877:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:877:                                     AAGGAAGACUGAUGAGGCCGAAAGGCCGAAAUGGCCAG38                                      (2) INFORMATION FOR SEQ ID NO:878:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:878:                                     UGAAGGAACUGAUGAGGCCGAAAGGCCGAAAGAUGGCC38                                      (2) INFORMATION FOR SEQ ID NO:879:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:879:                                     GCUGAAGGCUGAUGAGGCCGAAAGGCCGAAAGAGAUGG38                                      (2) INFORMATION FOR SEQ ID NO:880:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:880:                                     UGCUGAAGCUGAUGAGGCCGAAAGGCCGAAAAGAGAUG38                                      (2) INFORMATION FOR SEQ ID NO:881:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:881:                                     CACUGCUGCUGAUGAGGCCGAAAGGCCGAAAGGAAGAG38                                      (2) INFORMATION FOR SEQ ID NO:882:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:882:                                     CCACUGCUCUGAUGAGGCCGAAAGGCCGAAAAGGAAGA38                                      (2) INFORMATION FOR SEQ ID NO:883:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:883:                                     UAACUUCACUGAUGAGGCCGAAAGGCCGAAAUGCAGCA38                                      (2) INFORMATION FOR SEQ ID NO:884:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:884:                                     CUGCUAAUCUGAUGAGGCCGAAAGGCCGAAACUUCAUA38                                      (2) INFORMATION FOR SEQ ID NO:885:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:885:                                     CCUGCUAACUGAUGAGGCCGAAAGGCCGAAAACUUCAU38                                      (2) INFORMATION FOR SEQ ID NO:886:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:886:                                     UCCCUGCUCUGAUGAGGCCGAAAGGCCGAAAUAACUUC38                                      (2) INFORMATION FOR SEQ ID NO:887:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:887:                                     AUCCCUGCCUGAUGAGGCCGAAAGGCCGAAAAUAACUU38                                      (2) INFORMATION FOR SEQ ID NO:888:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:888:                                     GAAAACAGCUGAUGAGGCCGAAAGGCCGAAAUCCCUGC38                                      (2) INFORMATION FOR SEQ ID NO:889:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:889:                                     AAAAUGAACUGAUGAGGCCGAAAGGCCGAAACAGUAUC38                                      (2) INFORMATION FOR SEQ ID NO:890:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:890:                                     AAAAAUGACUGAUGAGGCCGAAAGGCCGAAAACAGUAU38                                      (2) INFORMATION FOR SEQ ID NO:891:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:891:                                     UAAAAAUGCUGAUGAGGCCGAAAGGCCGAAAAACAGUA38                                      (2) INFORMATION FOR SEQ ID NO:892:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:892:                                     UUAAAAAUCUGAUGAGGCCGAAAGGCCGAAAAAACAGU38                                      (2) INFORMATION FOR SEQ ID NO:893:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:893:                                     CCUUUAAACUGAUGAGGCCGAAAGGCCGAAAUGAAAAC38                                      (2) INFORMATION FOR SEQ ID NO:894:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:894:                                     UCCUUUAACUGAUGAGGCCGAAAGGCCGAAAAUGAAAA38                                      (2) INFORMATION FOR SEQ ID NO:895:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:895:                                     UUCCUUUACUGAUGAGGCCGAAAGGCCGAAAAAUGAAA38                                      (2) INFORMATION FOR SEQ ID NO:896:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:896:                                     GUUCCUUUCUGAUGAGGCCGAAAGGCCGAAAAAAUGAA38                                      (2) INFORMATION FOR SEQ ID NO:897:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:897:                                     AGUUCCUUCUGAUGAGGCCGAAAGGCCGAAAAAAAUGA38                                      (2) INFORMATION FOR SEQ ID NO:898:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:898:                                     CCAGAACUCUGAUGAGGCCGAAAGGCCGAAAGUUCCUU38                                      (2) INFORMATION FOR SEQ ID NO:899:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:899:                                     UGGCCCAGCUGAUGAGGCCGAAAGGCCGAAACUGAGUU38                                      (2) INFORMATION FOR SEQ ID NO:900:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:900:                                     AUGGCCCACUGAUGAGGCCGAAAGGCCGAAAACUGAGU38                                      (2) INFORMATION FOR SEQ ID NO:901:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:901:                                     UUUCCUCUCUGAUGAGGCCGAAAGGCCGAAAUGGCCCA38                                      (2) INFORMATION FOR SEQ ID NO:902:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:902:                                     AUUUCCUCCUGAUGAGGCCGAAAGGCCGAAAAUGGCCC38                                      (2) INFORMATION FOR SEQ ID NO:903:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:903:                                     CCAGCUUGCUGAUGAGGCCGAAAGGCCGAAACCUCAUU38                                      (2) INFORMATION FOR SEQ ID NO:904:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:904:                                     UCUUGGGUCUGAUGAGGCCGAAAGGCCGAAACCAGCUU38                                      (2) INFORMATION FOR SEQ ID NO:905:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:905:                                     UUCUUGGGCUGAUGAGGCCGAAAGGCCGAAAACCAGCU38                                      (2) INFORMATION FOR SEQ ID NO:906:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:906:                                     AGGGUGUGCUGAUGAGGCCGAAAGGCCGAAAUGCUUCU38                                      (2) INFORMATION FOR SEQ ID NO:907:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:907:                                     UGAAGGGACUGAUGAGGCCGAAAGGCCGAAACCCAGGG38                                      (2) INFORMATION FOR SEQ ID NO:908:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:908:                                     UUGAAGGGCUGAUGAGGCCGAAAGGCCGAAAACCCAGG38                                      (2) INFORMATION FOR SEQ ID NO:909:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:909:                                     GUUGAAGGCUGAUGAGGCCGAAAGGCCGAAAAACCCAG38                                      (2) INFORMATION FOR SEQ ID NO:910:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:910:                                     UAUGGUUGCUGAUGAGGCCGAAAGGCCGAAAGGGAAAC38                                      (2) INFORMATION FOR SEQ ID NO:911:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:911:                                     UUAUGGUUCUGAUGAGGCCGAAAGGCCGAAAAGGGAAA38                                      (2) INFORMATION FOR SEQ ID NO:912:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:912:                                     AUUUUUCUCUGAUGAGGCCGAAAGGCCGAAAUGGUUGA38                                      (2) INFORMATION FOR SEQ ID NO:913:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:913:                                     GCAGCAUCCUGAUGAGGCCGAAAGGCCGAAAUUUUUCU38                                      (2) INFORMATION FOR SEQ ID NO:914:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:914:                                     UUAUCAGACUGAUGAGGCCGAAAGGCCGAAAUGGCAGC38                                      (2) INFORMATION FOR SEQ ID NO:915:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:915:                                     CUUAUCAGCUGAUGAGGCCGAAAGGCCGAAAAUGGCAG38                                      (2) INFORMATION FOR SEQ ID NO:916:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:916:                                     CCUUAUCACUGAUGAGGCCGAAAGGCCGAAAAAUGGCA38                                      (2) INFORMATION FOR SEQ ID NO:917:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:917:                                     CCUUUCCUCUGAUGAGGCCGAAAGGCCGAAAUCAGAAA38                                      (2) INFORMATION FOR SEQ ID NO:918:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:918:                                     CAAAGAAGCUGAUGAGGCCGAAAGGCCGAAAUGUUUUC38                                      (2) INFORMATION FOR SEQ ID NO:919:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:919:                                     CCACAAAGCUGAUGAGGCCGAAAGGCCGAAAGUAUGUU38                                      (2) INFORMATION FOR SEQ ID NO:920:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:920:                                     UCCACAAACUGAUGAGGCCGAAAGGCCGAAAAGUAUGU38                                      (2) INFORMATION FOR SEQ ID NO:921:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:921:                                     CUUCCACACUGAUGAGGCCGAAAGGCCGAAAGAAGUAU38                                      (2) INFORMATION FOR SEQ ID NO:922:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:922:                                     UCUUCCACCUGAUGAGGCCGAAAGGCCGAAAAGAAGUA38                                      (2) INFORMATION FOR SEQ ID NO:923:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:923:                                     ACCUCCAGCUGAUGAGGCCGAAAGGCCGAAAUUUGUCU38                                      (2) INFORMATION FOR SEQ ID NO:924:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:924:                                     UCUCAUCACUGAUGAGGCCGAAAGGCCGAAACCUCCAG38                                      (2) INFORMATION FOR SEQ ID NO:925:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:925:                                     UUCUCAUCCUGAUGAGGCCGAAAGGCCGAAAACCUCCA38                                      (2) INFORMATION FOR SEQ ID NO:926:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:926:                                     GCUCCAGGCUGAUGAGGCCGAAAGGCCGAAACUGUCUC38                                      (2) INFORMATION FOR SEQ ID NO:927:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:927:                                     GUCUGGGACUGAUGAGGCCGAAAGGCCGAAAGCCUGGC38                                      (2) INFORMATION FOR SEQ ID NO:928:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:928:                                     UGUCUGGGCUGAUGAGGCCGAAAGGCCGAAAAGCCUGG38                                      (2) INFORMATION FOR SEQ ID NO:929:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:929:                                     AUGUCUGGCUGAUGAGGCCGAAAGGCCGAAAAAGCCUG38                                      (2) INFORMATION FOR SEQ ID NO:930:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:930:                                     UUCUGCUACUGAUGAGGCCGAAAGGCCGAAAUGUCUGG38                                      (2) INFORMATION FOR SEQ ID NO:931:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:931:                                     UCUUCUGCCUGAUGAGGCCGAAAGGCCGAAAUAUGUCU38                                      (2) INFORMATION FOR SEQ ID NO:932:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:932:                                     UUCCUGGACUGAUGAGGCCGAAAGGCCGAAAGUCUUCU38                                      (2) INFORMATION FOR SEQ ID NO:933:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:933:                                     AUUCCUGGCUGAUGAGGCCGAAAGGCCGAAAAGUCUUC38                                      (2) INFORMATION FOR SEQ ID NO:934:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:934:                                     AAUUCCUGCUGAUGAGGCCGAAAGGCCGAAAAAGUCUU38                                      (2) INFORMATION FOR SEQ ID NO:935:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:935:                                     UUUGGAUUCUGAUGAGGCCGAAAGGCCGAAAUUCCUGG38                                      (2) INFORMATION FOR SEQ ID NO:936:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:936:                                     CUUUGGAUCUGAUGAGGCCGAAAGGCCGAAAAUUCCUG38                                      (2) INFORMATION FOR SEQ ID NO:937:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:937:                                     GAUCUUUGCUGAUGAGGCCGAAAGGCCGAAAUUAAUUC38                                      (2) INFORMATION FOR SEQ ID NO:938:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:938:                                     ACAGCAUCCUGAUGAGGCCGAAAGGCCGAAAUCUUUGG38                                      (2) INFORMATION FOR SEQ ID NO:939:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:939:                                     GCUUCAAACUGAUGAGGCCGAAAGGCCGAAACAGCAUC38                                      (2) INFORMATION FOR SEQ ID NO:940:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:940:                                     UGCUUCAACUGAUGAGGCCGAAAGGCCGAAAACAGCAU38                                      (2) INFORMATION FOR SEQ ID NO:941:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:941:                                     AUGCUUCACUGAUGAGGCCGAAAGGCCGAAAAACAGCA38                                      (2) INFORMATION FOR SEQ ID NO:942:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:942:                                     AAUGCUUCCUGAUGAGGCCGAAAGGCCGAAAAAACAGC38                                      (2) INFORMATION FOR SEQ ID NO:943:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:943:                                     AAAACCCACUGAUGAGGCCGAAAGGCCGAAAUGCUUCA38                                      (2) INFORMATION FOR SEQ ID NO:944:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:944:                                     AAAAACCCCUGAUGAGGCCGAAAGGCCGAAAAUGCUUC38                                      (2) INFORMATION FOR SEQ ID NO:945:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:945:                                     AAUAGAAACUGAUGAGGCCGAAAGGCCGAAACCCAAAU38                                      (2) INFORMATION FOR SEQ ID NO:946:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:946:                                     AAAUAGAACUGAUGAGGCCGAAAGGCCGAAAACCCAAA38                                      (2) INFORMATION FOR SEQ ID NO:947:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:947:                                     GAAAUAGACUGAUGAGGCCGAAAGGCCGAAAAACCCAA38                                      (2) INFORMATION FOR SEQ ID NO:948:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:948:                                     AGAAAUAGCUGAUGAGGCCGAAAGGCCGAAAAAACCCA38                                      (2) INFORMATION FOR SEQ ID NO:949:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:949:                                     AAGAAAUACUGAUGAGGCCGAAAGGCCGAAAAAAACCC38                                      (2) INFORMATION FOR SEQ ID NO:950:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:950:                                     UGAAGAAACUGAUGAGGCCGAAAGGCCGAAAGAAAAAC38                                      (2) INFORMATION FOR SEQ ID NO:951:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:951:                                     ACUGAAGACUGAUGAGGCCGAAAGGCCGAAAUAGAAAA38                                      (2) INFORMATION FOR SEQ ID NO:952:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:952:                                     CACUGAAGCUGAUGAGGCCGAAAGGCCGAAAAUAGAAA38                                      (2) INFORMATION FOR SEQ ID NO:953:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:953:                                     CCACUGAACUGAUGAGGCCGAAAGGCCGAAAAAUAGAA38                                      (2) INFORMATION FOR SEQ ID NO:954:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:954:                                     AUCCACUGCUGAUGAGGCCGAAAGGCCGAAAGAAAUAG38                                      (2) INFORMATION FOR SEQ ID NO:955:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:955:                                     GAUCCACUCUGAUGAGGCCGAAAGGCCGAAAAGAAAUA38                                      (2) INFORMATION FOR SEQ ID NO:956:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:956:                                     ACUGUGAACUGAUGAGGCCGAAAGGCCGAAAUCCACUG38                                      (2) INFORMATION FOR SEQ ID NO:957:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:957:                                     CGACUGUGCUGAUGAGGCCGAAAGGCCGAAAGAUCCAC38                                      (2) INFORMATION FOR SEQ ID NO:958:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:958:                                     CCGACUGUCUGAUGAGGCCGAAAGGCCGAAAAGAUCCA38                                      (2) INFORMATION FOR SEQ ID NO:959:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:959:                                     CAAACUCCCUGAUGAGGCCGAAAGGCCGAAACUGUGAA38                                      (2) INFORMATION FOR SEQ ID NO:960:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:960:                                     UUGGGUCACUGAUGAGGCCGAAAGGCCGAAACUCCGAC38                                      (2) INFORMATION FOR SEQ ID NO:961:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:961:                                     UUUGGGUCCUGAUGAGGCCGAAAGGCCGAAAACUCCGA38                                      (2) INFORMATION FOR SEQ ID NO:962:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:962:                                     CUCUUCAACUGAUGAGGCCGAAAGGCCGAAACAUGUGU38                                      (2) INFORMATION FOR SEQ ID NO:963:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:963:                                     GCUCUUCACUGAUGAGGCCGAAAGGCCGAAAACAUGUG38                                      (2) INFORMATION FOR SEQ ID NO:964:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:964:                                     UGCUCUUCCUGAUGAGGCCGAAAGGCCGAAAAACAUGU38                                      (2) INFORMATION FOR SEQ ID NO:965:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:965:                                     AACACUGACUGAUGAGGCCGAAAGGCCGAAACCAGCUG38                                      (2) INFORMATION FOR SEQ ID NO:966:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:966:                                     UAACACUGCUGAUGAGGCCGAAAGGCCGAAAACCAGCU38                                      (2) INFORMATION FOR SEQ ID NO:967:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:967:                                     CUAACACUCUGAUGAGGCCGAAAGGCCGAAAAACCAGC38                                      (2) INFORMATION FOR SEQ ID NO:968:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:968:                                     CCCCUCCUCUGAUGAGGCCGAAAGGCCGAAACACUGAA38                                      (2) INFORMATION FOR SEQ ID NO:969:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:969:                                     ACCCCUCCCUGAUGAGGCCGAAAGGCCGAAAACACUGA38                                      (2) INFORMATION FOR SEQ ID NO:970:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:970:                                     GCCUUCUACUGAUGAGGCCGAAAGGCCGAAACACCCCU38                                      (2) INFORMATION FOR SEQ ID NO:971:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:971:                                     GUGCCUUCCUGAUGAGGCCGAAAGGCCGAAAUACACCC38                                      (2) INFORMATION FOR SEQ ID NO:972:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:972:                                     UCAUUUAACUGAUGAGGCCGAAAGGCCGAAACAUUCAU38                                      (2) INFORMATION FOR SEQ ID NO:973:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:973:                                     UUCAUUUACUGAUGAGGCCGAAAGGCCGAAAACAUUCA38                                      (2) INFORMATION FOR SEQ ID NO:974:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:974:                                     GUUCAUUUCUGAUGAGGCCGAAAGGCCGAAAAACAUUC38                                      (2) INFORMATION FOR SEQ ID NO:975:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:975:                                     GGUUCAUUCUGAUGAGGCCGAAAGGCCGAAAAAACAUU38                                      (2) INFORMATION FOR SEQ ID NO:976:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:976:                                     UGAACAAUCUGAUGAGGCCGAAAGGCCGAAAGGUUCAU38                                      (2) INFORMATION FOR SEQ ID NO:977:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:977:                                     UGUUGAACCUGAUGAGGCCGAAAGGCCGAAAUUAGGUU38                                      (2) INFORMATION FOR SEQ ID NO:978:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:978:                                     AAGUGUUGCUGAUGAGGCCGAAAGGCCGAAACAAUUAG38                                      (2) INFORMATION FOR SEQ ID NO:979:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:979:                                     UAAGUGUUCUGAUGAGGCCGAAAGGCCGAAAACAAUUA38                                      (2) INFORMATION FOR SEQ ID NO:980:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:980:                                     AAAGUCCUCUGAUGAGGCCGAAAGGCCGAAAGUGUUGA38                                      (2) INFORMATION FOR SEQ ID NO:981:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:981:                                     CAAAGUCCCUGAUGAGGCCGAAAGGCCGAAAAGUGUUG38                                      (2) INFORMATION FOR SEQ ID NO:982:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:982:                                     AACUCACACUGAUGAGGCCGAAAGGCCGAAAGUCCUAA38                                      (2) INFORMATION FOR SEQ ID NO:983:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:983:                                     CAACUCACCUGAUGAGGCCGAAAGGCCGAAAAGUCCUA38                                      (2) INFORMATION FOR SEQ ID NO:984:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:984:                                     GCCACUUCCUGAUGAGGCCGAAAGGCCGAAACUCACAA38                                      (2) INFORMATION FOR SEQ ID NO:985:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:985:                                     GAGAAAAUCUGAUGAGGCCGAAAGGCCGAAAGCCACUU38                                      (2) INFORMATION FOR SEQ ID NO:986:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:986:                                     CAGGAGAACUGAUGAGGCCGAAAGGCCGAAAUGAGCCA38                                      (2) INFORMATION FOR SEQ ID NO:987:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:987:                                     GCAGGAGACUGAUGAGGCCGAAAGGCCGAAAAUGAGCC38                                      (2) INFORMATION FOR SEQ ID NO:988:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:988:                                     UGCAGGAGCUGAUGAGGCCGAAAGGCCGAAAAAUGAGC38                                      (2) INFORMATION FOR SEQ ID NO:989:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:989:                                     AUGCAGGACUGAUGAGGCCGAAAGGCCGAAAAAAUGAG38                                      (2) INFORMATION FOR SEQ ID NO:990:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:990:                                     AUAUGCAGCUGAUGAGGCCGAAAGGCCGAAAGAAAAUG38                                      (2) INFORMATION FOR SEQ ID NO:991:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:991:                                     UCACAGCACUGAUGAGGCCGAAAGGCCGAAAUGCAGGA38                                      (2) INFORMATION FOR SEQ ID NO:992:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:992:                                     AUGCUCGACUGAUGAGGCCGAAAGGCCGAAAUUCCCAU38                                      (2) INFORMATION FOR SEQ ID NO:993:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:993:                                     UCAUGCUCCUGAUGAGGCCGAAAGGCCGAAAGAUUCCC38                                      (2) INFORMATION FOR SEQ ID NO:994:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:994:                                     CAGUUAGACUGAUGAGGCCGAAAGGCCGAAACACAGUU38                                      (2) INFORMATION FOR SEQ ID NO:995:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:995:                                     UCCAGUUACUGAUGAGGCCGAAAGGCCGAAAUACACAG38                                      (2) INFORMATION FOR SEQ ID NO:996:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:996:                                     AGUCCAGUCUGAUGAGGCCGAAAGGCCGAAAGAUACAC38                                      (2) INFORMATION FOR SEQ ID NO:997:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:997:                                     GAUGUGCACUGAUGAGGCCGAAAGGCCGAAAGUCCAGU38                                      (2) INFORMATION FOR SEQ ID NO:998:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:998:                                     CGAUGUGCCUGAUGAGGCCGAAAGGCCGAAAAGUCCAG38                                      (2) INFORMATION FOR SEQ ID NO:999:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:999:                                     CCCGUAACCUGAUGAGGCCGAAAGGCCGAAAUGUGCAA38                                      (2) INFORMATION FOR SEQ ID NO:1000:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1000:                                    ACACCCGUCUGAUGAGGCCGAAAGGCCGAAACGAUGUG38                                      (2) INFORMATION FOR SEQ ID NO:1001:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1001:                                    AACACCCGCUGAUGAGGCCGAAAGGCCGAAAACGAUGU38                                      (2) INFORMATION FOR SEQ ID NO:1002:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1002:                                    CCUGUUUGCUGAUGAGGCCGAAAGGCCGAAACACCCGU38                                      (2) INFORMATION FOR SEQ ID NO:1003:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1003:                                    GCCUGUUUCUGAUGAGGCCGAAAGGCCGAAAACACCCG38                                      (2) INFORMATION FOR SEQ ID NO:1004:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1004:                                    UGCAAGCUCUGAUGAGGCCGAAAGGCCGAAAGCAGCAG38                                      (2) INFORMATION FOR SEQ ID NO:1005:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1005:                                    GUGCAAGCCUGAUGAGGCCGAAAGGCCGAAAAGCAGCA38                                      (2) INFORMATION FOR SEQ ID NO:1006:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1006:                                    UCAAGUGCCUGAUGAGGCCGAAAGGCCGAAAGCUAAGC38                                      (2) INFORMATION FOR SEQ ID NO:1007:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1007:                                    AUGUGAUCCUGAUGAGGCCGAAAGGCCGAAAGUGCAAG38                                      (2) INFORMATION FOR SEQ ID NO:1008:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1008:                                    UUCCAUGUCUGAUGAGGCCGAAAGGCCGAAAUCAAGUG38                                      (2) INFORMATION FOR SEQ ID NO:1009:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1009:                                    UCUCGUGGCUGAUGAGGCCGAAAGGCCGAAAGCUCCCU38                                      (2) INFORMATION FOR SEQ ID NO:1010:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1010:                                    GUCUCGUGCUGAUGAGGCCGAAAGGCCGAAAAGCUCCC38                                      (2) INFORMATION FOR SEQ ID NO:1011:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1011:                                    CACAUGAGCUGAUGAGGCCGAAAGGCCGAAACUUCCCC38                                      (2) INFORMATION FOR SEQ ID NO:1012:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1012:                                    UCACACAUCUGAUGAGGCCGAAAGGCCGAAAGUACUUC38                                      (2) INFORMATION FOR SEQ ID NO:1013:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1013:                                    AUAGACACCUGAUGAGGCCGAAAGGCCGAAAUCACUCG38                                      (2) INFORMATION FOR SEQ ID NO:1014:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1014:                                    UCCACAUACUGAUGAGGCCGAAAGGCCGAAACACAAUC38                                      (2) INFORMATION FOR SEQ ID NO:1015:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1015:                                    AAUCCACACUGAUGAGGCCGAAAGGCCGAAAGACACAA38                                      (2) INFORMATION FOR SEQ ID NO:1016:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1016:                                    GGGCAAAUCUGAUGAGGCCGAAAGGCCGAAAUCCACAU38                                      (2) INFORMATION FOR SEQ ID NO:1017:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1017:                                    UGGGCAAACUGAUGAGGCCGAAAGGCCGAAAAUCCACA38                                      (2) INFORMATION FOR SEQ ID NO:1018:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1018:                                    AAUGGGCACUGAUGAGGCCGAAAGGCCGAAAUAAUCCA38                                      (2) INFORMATION FOR SEQ ID NO:1019:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1019:                                    UAAUGGGCCUGAUGAGGCCGAAAGGCCGAAAAUAAUCC38                                      (2) INFORMATION FOR SEQ ID NO:1020:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1020:                                    UAUUAAAUCUGAUGAGGCCGAAAGGCCGAAAUGGGCAA38                                      (2) INFORMATION FOR SEQ ID NO:1021:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1021:                                    UUAUUAAACUGAUGAGGCCGAAAGGCCGAAAAUGGGCA38                                      (2) INFORMATION FOR SEQ ID NO:1022:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1022:                                    CUUUAUUACUGAUGAGGCCGAAAGGCCGAAAUAAUGGG38                                      (2) INFORMATION FOR SEQ ID NO:1023:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1023:                                    UCUUUAUUCUGAUGAGGCCGAAAGGCCGAAAAUAAUGG38                                      (2) INFORMATION FOR SEQ ID NO:1024:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1024:                                    CUCUUUAUCUGAUGAGGCCGAAAGGCCGAAAAAUAAUG38                                      (2) INFORMATION FOR SEQ ID NO:1025:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1025:                                    AUCCUCUUCUGAUGAGGCCGAAAGGCCGAAAUUAAAUA38                                      (2) INFORMATION FOR SEQ ID NO:1026:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1026:                                    AAUUGACACUGAUGAGGCCGAAAGGCCGAAAUCCUCUU38                                      (2) INFORMATION FOR SEQ ID NO:1027:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1027:                                    CGCACAGCAGAAGUAGGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1028:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1028:                                    GCUGAGCAAGAAGCCACGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1029:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1029:                                    AAUGGAUAAGAAGAGCAAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1030:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1030:                                    UCCUAACAAGAAGUUUCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1031:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1031:                                    UUUUUAACAGAAGGACCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1032:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1032:                                    UGACCAACAGAAGGAACUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1033:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1033:                                    UUUGGCAAAGAAGGUGUAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1034:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1034:                                    GCAGAAUCAGAAGCAUCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1035:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1035:                                    UUCUCAACAGAAGAAUCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1036:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1036:                                    GCUUUCUCAGAAGCAGAAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1037:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1037:                                    AUUUCAUGAGAAGCAACGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1038:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1038:                                    CGAGUCAGAGAAGUGAGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1039:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1039:                                    GGAACCGAAGAAGGUCUGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1040:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1040:                                    ACAGGCGGAGAAGAGUCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1041:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1041:                                    UUGAGACAAGAAGAACCGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1042:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1042:                                    CAUCUUGAAGAAGGCGGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1043:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1043:                                    CAUAGAGGAGAAGAAUGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1044:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1044:                                    UCAGGGGAAGAAGGGGGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1045:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1045:                                    UCUGGAGGAGAAGGUUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1046:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1046:                                    AAGGACAAAGAAGGAUCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1047:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1047:                                    CUUUAAAGAGAAGGAUUUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1048:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1048:                                    UCUUCAAAAGAAGCAUCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1049:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1049:                                    CAAACUCCAGAAGUGAAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1050:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1050:                                    AUUAAGCCAGAAGUUACUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1051:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1051:                                    ACAGCACAAGAAGGAGAAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1052:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1052:                                    AGCUAAGCAGAAGCCCAUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1053:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1053:                                    GCAAGCUAAGAAGCAGCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1054:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1054:                                    UCCUACUGUUGCUGUGCG18                                                          (2) INFORMATION FOR SEQ ID NO:1055:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1055:                                    CGUGGCAGUUUGCUCAGC18                                                          (2) INFORMATION FOR SEQ ID NO:1056:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1056:                                    UUGCUCAGCCUAUCCAUU18                                                          (2) INFORMATION FOR SEQ ID NO:1057:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1057:                                    UGAAACAGUUUGUUAGGA18                                                          (2) INFORMATION FOR SEQ ID NO:1058:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1058:                                    UGGUCCUGUUGUUAAAAA18                                                          (2) INFORMATION FOR SEQ ID NO:1059:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1059:                                    AGUUCCUGAUGUUGGUCA18                                                          (2) INFORMATION FOR SEQ ID NO:1060:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1060:                                    UACACCAGAUUUGCCAAA18                                                          (2) INFORMATION FOR SEQ ID NO:1061:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1061:                                    AGAUGCUGUUGAUUCUGC18                                                          (2) INFORMATION FOR SEQ ID NO:1062:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1062:                                    UGAUUCUGCUGUUGAGAA18                                                          (2) INFORMATION FOR SEQ ID NO:1063:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1063:                                    UUCUGCUGUUGAGAAAGC18                                                          (2) INFORMATION FOR SEQ ID NO:1064:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1064:                                    CGUUGCUGCUCAUGAAAU18                                                          (2) INFORMATION FOR SEQ ID NO:1065:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1065:                                    ACUCACAGACCUGACUCG18                                                          (2) INFORMATION FOR SEQ ID NO:1066:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1066:                                    CAGACCUGACUCGGUUCC18                                                          (2) INFORMATION FOR SEQ ID NO:1067:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1067:                                    UGACUCGGUUCCGCCUGU18                                                          (2) INFORMATION FOR SEQ ID NO:1068:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1068:                                    CGGUUCCGCCUGUCUCAA18                                                          (2) INFORMATION FOR SEQ ID NO:1069:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1069:                                    UCCGCCUGUCUCAAGAUG18                                                          (2) INFORMATION FOR SEQ ID NO:1070:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1070:                                    GCAUUCAGUCCCUCUAUG18                                                          (2) INFORMATION FOR SEQ ID NO:1071:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1071:                                    UCCCCCUGACUCCCCUGA18                                                          (2) INFORMATION FOR SEQ ID NO:1072:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1072:                                    GGAACCUGUCCCUCCAGA18                                                          (2) INFORMATION FOR SEQ ID NO:1073:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1073:                                    UGAUCCUGCUUUGUCCUU18                                                          (2) INFORMATION FOR SEQ ID NO:1074:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1074:                                    AAAUCCUGAUCUUUAAAG18                                                          (2) INFORMATION FOR SEQ ID NO:1075:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1075:                                    UGAUGCUGUUUUUGAAGA18                                                          (2) INFORMATION FOR SEQ ID NO:1076:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1076:                                    CUUCACAGUUGGAGUUUG18                                                          (2) INFORMATION FOR SEQ ID NO:1077:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1077:                                    AGUAACAGCUGGCUUAAU18                                                          (2) INFORMATION FOR SEQ ID NO:1078:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1078:                                    UUCUCCUGCCUGUGCUGU18                                                          (2) INFORMATION FOR SEQ ID NO:1079:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1079:                                    AUGGGCUGCUGCUUAGCU18                                                          (2) INFORMATION FOR SEQ ID NO:1080:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1080:                                    GGCUGCUGCUUAGCUUGC18                                                          (2) INFORMATION FOR SEQ ID NO:1081:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1081:                                    CCACGCACAGAAGUAGCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1082:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1082:                                    AGUGGAUAAGAAGAGCAAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1083:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1083:                                    UUUUAACAAGAAGUUUCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1084:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1084:                                    UUUUUAACAGAAGGACUAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1085:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1085:                                    UGACCAACAGAAGGAACGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1086:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1086:                                    CUUGGCAGAGAAGGUGUGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1087:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1087:                                    GCAGCAUCAGAAGCAUCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1088:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1088:                                    AGCUCAUGAGAAGCAACAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1089:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1089:                                    CCGAGUGAAGAAGACCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1090:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1090:                                    CUGGGUACAGAAGCGCUUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1091:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1091:                                    GCGUUGUAAGAAGGGUACACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1092:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1092:                                    CGGGCCAGAGAAGUGAAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1093:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1093:                                    AAAGGCGGAGAAGGGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1094:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1094:                                    UUGAGAAAAGAAGAACCGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1095:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1095:                                    GAGGCAGGAGAAGGUCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1096:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1096:                                    UCAGGAGAAGAAGGGGCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1097:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1097:                                    CCUGGAGGAGAAGGUUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1098:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1098:                                    AAGGACAGAGAAGGAUCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1099:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1099:                                    CAUCGAAGAGAAGAUCUGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1100:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1100:                                    CUUUAAAGAGAAGAAUUUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1101:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1101:                                    AAAAUGAAAGAAGUAUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1102:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1102:                                    UGGCCCAGAGAAGAGUUCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1103:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1103:                                    GCUCCAGGAGAAGUCUCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1104:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1104:                                    GCUUCAAAAGAAGCAUCGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1105:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1105:                                    CAAACUCCAGAAGUGAAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1106:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1106:                                    CUGAAACCAGAAGUUGCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1107:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1107:                                    AGCUAAGCAGAAGCCUGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1108:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1108:                                    GCAAGCUAAGAAGCAGCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1109:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1109:                                    AAUCACUCAGAAGUCACAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1110:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1110:                                    UGCUACUGCUGUGCGUGG18                                                          (2) INFORMATION FOR SEQ ID NO:1111:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1111:                                    UUGCUCAGCCUAUCCACU18                                                          (2) INFORMATION FOR SEQ ID NO:1112:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1112:                                    UGAAACAGUUUGUUAAAA18                                                          (2) INFORMATION FOR SEQ ID NO:1113:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1113:                                    UAGUCCUGUUGUUAAAAA18                                                          (2) INFORMATION FOR SEQ ID NO:1114:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1114:                                    CGUUCCUGAUGUUGGUCA18                                                          (2) INFORMATION FOR SEQ ID NO:1115:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1115:                                    CACACCGGAUCUGCCAAG18                                                          (2) INFORMATION FOR SEQ ID NO:1116:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1116:                                    AGAUGCUGUUGAUGCUGC18                                                          (2) INFORMATION FOR SEQ ID NO:1117:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1117:                                    UGUUGCUGCUCAUGAGCU18                                                          (2) INFORMATION FOR SEQ ID NO:1118:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1118:                                    UGGGUCUGUUUCACUCGG18                                                          (2) INFORMATION FOR SEQ ID NO:1119:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1119:                                    AAGCGCUGAUGUACCCAG18                                                          (2) INFORMATION FOR SEQ ID NO:1120:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1120:                                    GUACCCAGUCUACAACGC18                                                          (2) INFORMATION FOR SEQ ID NO:1121:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1121:                                    CUUCACAGACCUGGCCCG18                                                          (2) INFORMATION FOR SEQ ID NO:1122:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1122:                                    UGGCCCGGUUCCGCCUUU18                                                          (2) INFORMATION FOR SEQ ID NO:1123:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1123:                                    CGGUUCCGCCUUUCUCAA18                                                          (2) INFORMATION FOR SEQ ID NO:1124:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1124:                                    UGGACCGGCCCCUGCCUC18                                                          (2) INFORMATION FOR SEQ ID NO:1125:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1125:                                    GGCCCCUGCCUCUCCUGA18                                                          (2) INFORMATION FOR SEQ ID NO:1126:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1126:                                    GGAACCUGUCCCUCCAGG18                                                          (2) INFORMATION FOR SEQ ID NO:1127:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1127:                                    UGAUCCAGAUCUGUCCUU18                                                          (2) INFORMATION FOR SEQ ID NO:1128:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1128:                                    CAGAUCUGUCCUUCGAUG18                                                          (2) INFORMATION FOR SEQ ID NO:1129:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1129:                                    AAAUUCUGUUCUUUAAAG18                                                          (2) INFORMATION FOR SEQ ID NO:1130:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1130:                                    GGAUACUGUUUUCAUUUU18                                                          (2) INFORMATION FOR SEQ ID NO:1131:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1131:                                    GAACUCAGUUCUGGGCCA18                                                          (2) INFORMATION FOR SEQ ID NO:1132:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1132:                                    AGAGACAGUCCCUGGAGC18                                                          (2) INFORMATION FOR SEQ ID NO:1133:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1133:                                    CGAUGCUGUUUUUGAAGC18                                                          (2) INFORMATION FOR SEQ ID NO:1134:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1134:                                    CUUCACAGUCGGAGUUUG18                                                          (2) INFORMATION FOR SEQ ID NO:1135:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1135:                                    AGCAACAGCUGGUUUCAG18                                                          (2) INFORMATION FOR SEQ ID NO:1136:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1136:                                    ACAGGCUGCUGCUUAGCU18                                                          (2) INFORMATION FOR SEQ ID NO:1137:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1137:                                    GGCUGCUGCUUAGCUUGC18                                                          (2) INFORMATION FOR SEQ ID NO:1138:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1138:                                    UGUGACAGACGAGUGAUU18                                                          (2) INFORMATION FOR SEQ ID NO:1139:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1139:                                    GCCAUCUCUUCCUUC15                                                             (2) INFORMATION FOR SEQ ID NO:1140:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1140:                                    GAAGGAACUGAUGAGGCCGAAAGGCCGAAAGAUGGC36                                        (2) INFORMATION FOR SEQ ID NO:1141:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1141:                                    GCCAUCUCUUCCUUC15                                                             (2) INFORMATION FOR SEQ ID NO:1142:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 38 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1142:                                    GAAGGAACUGAUGAGGGCCGAAAGGCCGAAAGAUGGCT38                                      (2) INFORMATION FOR SEQ ID NO:1143:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1143:                                    AUGCUGUUUUUGAAG15                                                             (2) INFORMATION FOR SEQ ID NO:1144:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 37 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1144:                                    CUUCAAACUGAUGAGGCCGAAAGGCCGAAACAGCAUT37                                       (2) INFORMATION FOR SEQ ID NO:1145:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1145:                                    CUGUUUUUGAAGAAU15                                                             (2) INFORMATION FOR SEQ ID NO:1146:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 37 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1146:                                    AUUCUUCCUGAUGAGGCCGAAAGGCCGAAAAAACAGT37                                       (2) INFORMATION FOR SEQ ID NO:1147:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1147:                                    CUGUUUUUGAAGCAU15                                                             (2) INFORMATION FOR SEQ ID NO:1148:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 37 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1148:                                    AUGCUUCCUGAUGAGGCCGAAAGGCCGAAAAAACAGT37                                       (2) INFORMATION FOR SEQ ID NO:1149:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 22 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1149:                                    CUUAUGAGGCCGAAAGGCCGAU22                                                      (2) INFORMATION FOR SEQ ID NO:1150:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 22 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1150:                                    CUGAUGAGGCCGAAAGGCCGAA22                                                      (2) INFORMATION FOR SEQ ID NO:1151:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 20 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1151:                                    AATGAAAACGAGGTCCTTGC20                                                        __________________________________________________________________________

We claim:
 1. A method of reducing levels of Stromelysin RNA in amammalian synovium by administering to said mammal an enzymatic RNAmolecule which specifically cleaves Stromelysin RNA.
 2. The method ofclaim 1 wherein said enzymatic RNA molecule specifically cleaves targetmRNA having a sequence selected from SEQ. ID. NOS. 1-367.